ID H0UWD6_CAVPO Unreviewed; 340 AA.
AC H0UWD6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Proline rich transmembrane protein 2 {ECO:0000313|Ensembl:ENSCPOP00000001366.3};
GN Name=PRRT2 {ECO:0000313|Ensembl:ENSCPOP00000001366.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000001366.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000001366.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000001366.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CD225/Dispanin family.
CC {ECO:0000256|ARBA:ARBA00006843}.
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DR EMBL; AAKN02007767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003478280.1; XM_003478232.3.
DR AlphaFoldDB; H0UWD6; -.
DR STRING; 10141.ENSCPOP00000001366; -.
DR Ensembl; ENSCPOT00000001530.3; ENSCPOP00000001366.3; ENSCPOG00000001510.4.
DR GeneID; 100727070; -.
DR KEGG; cpoc:100727070; -.
DR CTD; 112476; -.
DR VEuPathDB; HostDB:ENSCPOG00000001510; -.
DR eggNOG; ENOG502S2U1; Eukaryota.
DR GeneTree; ENSGT00940000161103; -.
DR HOGENOM; CLU_070349_0_0_1; -.
DR InParanoid; H0UWD6; -.
DR OMA; DPQPDCQ; -.
DR OrthoDB; 4641723at2759; -.
DR TreeFam; TF331357; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000001510; Expressed in cerebellum and 13 other cell types or tissues.
DR GO; GO:0043679; C:axon terminus; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0042734; C:presynaptic membrane; IEA:Ensembl.
DR GO; GO:0008021; C:synaptic vesicle; IEA:Ensembl.
DR GO; GO:0017075; F:syntaxin-1 binding; IEA:Ensembl.
DR GO; GO:1905513; P:negative regulation of short-term synaptic potentiation; IEA:Ensembl.
DR GO; GO:0035544; P:negative regulation of SNARE complex assembly; IEA:Ensembl.
DR GO; GO:0050884; P:neuromuscular process controlling posture; IEA:Ensembl.
DR GO; GO:0150037; P:regulation of calcium-dependent activation of synaptic vesicle fusion; IEA:Ensembl.
DR GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IEA:Ensembl.
DR InterPro; IPR007593; CD225/Dispanin_fam.
DR PANTHER; PTHR14948; NG5; 1.
DR PANTHER; PTHR14948:SF20; PROLINE-RICH TRANSMEMBRANE PROTEIN 2; 1.
DR Pfam; PF04505; CD225; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 268..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..211
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 340 AA; 34876 MW; 9A03F75F51CD65DB CRC64;
MAASPSEVSE MKGVEEIPET QGEGHSNFEA GTGPLPVLAG VPDQPEALQP GPDTTAAPVD
LGPNAGLAPE TTETPTGAPE TVQAIDLSLN PGGESKANSS PGEASQEPAS KPAVNKEATA
DQESEQESAA PPEPASEPAT KLDTQSDPQP ASQPTPKPVQ PELPTHEDPT LTENVGEKQE
NGAVVPLQAG DGEEGPAPQP HSPPSTKPSP ANGAPPRVLQ QLVEEDRIGR APSGHPGSPR
GSLSRHPSSQ LVGPGVEGGE GTQKPRDYII LAILSCFCPM WPVNIVAFAY AVMSRNSLQQ
GDVDGAQRLG RVAKLLSIVA LVGGVLIIIA SCVINLGVYK
//
