ID H0UWH0_CAVPO Unreviewed; 1196 AA.
AC H0UWH0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Synapse defective Rho GTPase homolog 2 {ECO:0000313|Ensembl:ENSCPOP00000001404.3};
GN Name=SYDE2 {ECO:0000313|Ensembl:ENSCPOP00000001404.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000001404.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000001404.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000001404.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02004857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0UWH0; -.
DR STRING; 10141.ENSCPOP00000001404; -.
DR Ensembl; ENSCPOT00000001572.3; ENSCPOP00000001404.3; ENSCPOG00000001552.4.
DR VEuPathDB; HostDB:ENSCPOG00000001552; -.
DR eggNOG; KOG1452; Eukaryota.
DR GeneTree; ENSGT01030000234635; -.
DR HOGENOM; CLU_005764_1_0_1; -.
DR InParanoid; H0UWH0; -.
DR OMA; PMLKSPF; -.
DR TreeFam; TF323458; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000001552; Expressed in liver and 9 other cell types or tissues.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46150; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR PANTHER; PTHR46150:SF1; RHO GTPASE-ACTIVATING PROTEIN SYDE2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 662..781
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 818..1033
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1196 AA; 133178 MW; 6D1D3D3ABD4786D7 CRC64;
MHDLTPDSGT RRGGLGSADR GSPAGARAAG LPPFPRGAAQ RRACRRALQP GGGDCPRQQV
SPPWSPLRES GAGGLRCPRM RLSRSRSLES LQVDAKLPAF QRWPSDSYIR CGARGDRDEP
PPRGGGMDGW SWGGGARATE PADLPASRHS PARPPLAKPI RGFCGHLCGK PAAKTTVPRG
PPFLRPPAVT VGKLQKWMYK GRLLSLGMKG RARGPAPKVP GAPAASANAS PLKVQENHGL
SLPPDQRVTL TDLLEDVYGS SVKRRELEDL KDNIEFTGHK PLNSITVSKK RNWLYQSSLR
ALNPEEENKK YHNRSNLSVS PVSPPYHQLS QPFLKSSEEY CTYMVCNATD SSLSRNCSID
FNEENDADDE GEIWYNPIPE DDDLGMSSAL SFGEANPGTL KLPVTSLSIL SDSDLMKAEQ
HTEDLLCSSE HMGDIQTMQL NEMNPTNFIH STEFVTQHTQ RLGRKTQEDM MVEDSPILKS
PFAGPGVLAA TNRTELGIME PSSPSPSPVK KGSSISWSLP DKIKSPRTVR KLSMKMKKLP
EFSRKLSVKG TWNNINSPES TPSFSKSSCR EVHHTVILPS GNTTTAAKRN VISLYHLDTT
VSSQHSYQNK TSVNSKYSCK GGYLSDGDSP ELITKSSKHG PENKFGKGKE IIPSSCKNEI
DIDAFRHYSF SDQPKCSQHI SGLMSVHFYG AEDLKPPRID SKDVFCAIQV DSVNKARTAL
LTCRTTFLDM DHTFNIEIEN AQHLKLVVFS WEPTPRKNRV CCHGTVVLPT LFRVTKTHQL
AVKLEPRGLI YVKVTLMEQW ENSLHGLDKN RDSVLFGVDI QKVVERENVG LMVPLLIQKC
IMEIENRGCQ VVGLYRLCGS AAVKKELREA FERDSKTVGL CENQYPDINV ITGVLKDYLR
ELPSPLITKQ LYEAVLDAMV KSPLKMSSNG CENDPSDSKY TVDLLNCLPD VEKATLKMLL
DHLKLVASYH EVNKMTCQNL AVCFGPVLLN QRQETSTHNN RVFTDSEELA SALDFKKHIE
VLHYLLQLWP VHHVTVRESA DSLFAEQSSS LNYLRRKKER PSMLNLSSAN SLGVLRPRQT
RLDSPLSNRY AGDWSSCGEN YFLNTREDLN GVDYDDVPSE DREDREGYGR MEGPEIMIEQ
PIPTSRECTF QSYLRMQTIE STVDRKVNLK DLQESIDTLI GNLERELNKN KVNISI
//
