ID H0UWZ9_CAVPO Unreviewed; 944 AA.
AC H0UWZ9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Unc-45 myosin chaperone A {ECO:0000313|Ensembl:ENSCPOP00000001599.2};
GN Name=UNC45A {ECO:0000313|Ensembl:ENSCPOP00000001599.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000001599.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000001599.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000001599.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}.
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DR EMBL; AAKN02016024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003475533.2; XM_003475485.3.
DR AlphaFoldDB; H0UWZ9; -.
DR STRING; 10141.ENSCPOP00000001599; -.
DR Ensembl; ENSCPOT00000001789.3; ENSCPOP00000001599.2; ENSCPOG00000001768.4.
DR GeneID; 100727800; -.
DR KEGG; cpoc:100727800; -.
DR CTD; 55898; -.
DR VEuPathDB; HostDB:ENSCPOG00000001768; -.
DR eggNOG; KOG4151; Eukaryota.
DR GeneTree; ENSGT00940000159320; -.
DR HOGENOM; CLU_007331_0_0_1; -.
DR InParanoid; H0UWZ9; -.
DR OMA; LDQKHED; -.
DR OrthoDB; 1094381at2759; -.
DR TreeFam; TF314096; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000001768; Expressed in zone of skin and 13 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR024660; UCS_central_dom.
DR PANTHER; PTHR45994; FI21225P1; 1.
DR PANTHER; PTHR45994:SF3; PROTEIN UNC-45 HOMOLOG A; 1.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF13181; TPR_8; 1.
DR Pfam; PF11701; UNC45-central; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 2.
PE 4: Predicted;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Myogenesis {ECO:0000256|ARBA:ARBA00022541};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 21..54
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 92..125
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 362..505
FT /note="UNC-45/Cro1/She4 central"
FT /evidence="ECO:0000259|Pfam:PF11701"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 944 AA; 103131 MW; 519366B07CC8CB15 CRC64;
MTVSGPGTPE PRPTIPGASS AEQLRKEGNE LFKCGDYEGA LTAYTQALDL GATPQDRAVL
HRNRAACHLK LEEYEKAETE ASKAIDKDGG DVKALYRRSQ ALEKLGRLDQ AVLDLQRCVS
LEPKNKVFQE ALRSIGGQIQ EKVRYMSSTD AKVEQMFQIL LDPDEKGTEK KQKASQNLVV
LAREDAGAEK IFRNNGVQLL QRLLDTGETD LMLAALRTLV GICSEHQSRT VATLSVLGTR
RVVSILGVEN QAVSLAACHL LQVMFDALRE GVKKGFRGKE GAIIVEPGRE LKVLITNLLE
LLTEVGVSGQ GRDNALTLLI KMVPRKSPKD PDNSLTLWII DQGLKKILQV GGSLQDPAGE
LAVTANSRMS ASILLSKLFD DLKCDAEREN FHRLCESYIK SWFEGQGLAG KLRAIQTVSC
LLQGPCDAGN RALELSGVME SVIALCASEQ EEEQLVAVEA LIHAAGKAKR ASFITASGVS
LLKDLYKRSE KDSIRIRALV GLCKLGSAGG TDFSMKQFAE GSTLKLAKQC RKWLCNEQID
AGTRRWAVEG LAYLTFDADV KEEFVEDGAA LKALFQLSRS EERSVLFAVA SALVNCTNSY
DYEEPDPKMV ELAKYAKQHV PEQHPKDKPS FVQVRVKKLL AAGVVSAMTC MVKTESPVLT
NSCRELLSRV FLALVEEVED RGVVVAQGGG KALIPLALEG TEVGQTKAAQ ALAKLTITSN
PEMTFPGERI YEVVRPLVSL LHLDRSGLQN FEALMALTNL AGISERLQQK ILKEKAVPMI
EGYMFEEHEM LRRAATECMC NLAMNKEVQD LFEAEGNDRL KLLVLYSGED DELLRRAAAG
GLAMLTSARP SLCSRIPQVT THWLEILQAL LLSPNQELQH RGAVVVLNMV EASREIASTL
MESEVLEILS VLAKGKEGPV ARAAAACLVK AVEYGLIQPN QGAE
//
