ID H0UXX5_CAVPO Unreviewed; 128 AA.
AC H0UXX5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Huntingtin interacting protein K {ECO:0000313|Ensembl:ENSCPOP00000001970.3};
GN Name=HYPK {ECO:0000313|Ensembl:ENSCPOP00000001970.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000001970.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000001970.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000001970.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02015947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0UXX5; -.
DR Ensembl; ENSCPOT00000002201.3; ENSCPOP00000001970.3; ENSCPOG00000002173.4.
DR VEuPathDB; HostDB:ENSCPOG00000002173; -.
DR GeneTree; ENSGT00390000008502; -.
DR HOGENOM; CLU_128817_1_1_1; -.
DR TreeFam; TF325606; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000002173; Expressed in heart left ventricle and 12 other cell types or tissues.
DR CDD; cd14361; UBA_HYPK; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR038922; HYPK_UBA.
DR InterPro; IPR044034; NAC-like_UBA.
DR PANTHER; PTHR31184:SF2; HUNTINGTIN-INTERACTING PROTEIN K; 1.
DR PANTHER; PTHR31184; HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER; 1.
DR Pfam; PF19026; HYPK_UBA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 87..127
FT /note="Nascent polypeptide-associated complex subunit
FT alpha-like UBA"
FT /evidence="ECO:0000259|Pfam:PF19026"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 128 AA; 14594 MW; 517312DE5D18C266 CRC64;
LRRRGEDMAT EGDVELELET ETSCPERPPE KPRKHDSGAA DLERVTDYAE EKEIQSSNLE
TAMSVIGDRR SREQKARQER EKELAKVTIK KEDLELIMSE MEISRAAAER SLREHMGNVV
EALIALTN
//
