ID H0UY71_CAVPO Unreviewed; 416 AA.
AC H0UY71;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Lysine demethylase 8 {ECO:0000313|Ensembl:ENSCPOP00000002073.3};
GN Name=KDM8 {ECO:0000313|Ensembl:ENSCPOP00000002073.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000002073.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000002073.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000002073.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02007743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003477873.1; XM_003477825.3.
DR RefSeq; XP_012997405.1; XM_013141951.1.
DR AlphaFoldDB; H0UY71; -.
DR STRING; 10141.ENSCPOP00000002073; -.
DR Ensembl; ENSCPOT00000002314.3; ENSCPOP00000002073.3; ENSCPOG00000002282.4.
DR GeneID; 100723684; -.
DR KEGG; cpoc:100723684; -.
DR CTD; 79831; -.
DR VEuPathDB; HostDB:ENSCPOG00000002282; -.
DR eggNOG; KOG2132; Eukaryota.
DR GeneTree; ENSGT00940000158074; -.
DR HOGENOM; CLU_016785_0_3_1; -.
DR InParanoid; H0UY71; -.
DR OMA; VYPHETH; -.
DR OrthoDB; 11696at2759; -.
DR TreeFam; TF315056; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000002282; Expressed in cerebellum and 13 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0004175; F:endopeptidase activity; IEA:Ensembl.
DR GO; GO:0051864; F:histone H3K36 demethylase activity; IEA:Ensembl.
DR GO; GO:0035064; F:methylated histone binding; IEA:Ensembl.
DR GO; GO:0002039; F:p53 binding; IEA:Ensembl.
DR GO; GO:0106157; F:peptidyl-arginine 3-dioxygenase activity; IEA:Ensembl.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:Ensembl.
DR GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
DR GO; GO:1901796; P:regulation of signal transduction by p53 class mediator; IEA:Ensembl.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR InterPro; IPR041667; Cupin_8.
DR InterPro; IPR003347; JmjC_dom.
DR PANTHER; PTHR12461:SF97; BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7-RELATED; 1.
DR PANTHER; PTHR12461; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED; 1.
DR Pfam; PF13621; Cupin_8; 1.
DR SMART; SM00558; JmjC; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51184; JMJC; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 271..416
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
SQ SEQUENCE 416 AA; 46637 MW; AB671DCB366FEC71 CRC64;
MAEGTDGPGD ALWEALVALL PPSKEDLKLD LGEKVDRGVA LLLQQAVELF HGGQQGECLQ
ASEAALDYAW EKLNTGPWQD VDKAWRQVYA FSCLLKTLCL CRPPREATAV AAALRVCDMG
LLMGAAILGD ILIRVVAVLQ AHLVSGKRPN CSPSQQLSSQ ELSSMKKAKR DHVLAPDVSL
ERAVPRLRCP SLQHFQKYFL APGMPVILEG VADHWPCMKK WSLDYIQEMA GCRTVPVEVG
SRYTDEDWSQ TLMTVNEFIS KYITNEARDI GYLAQHQLFD QIPELKRDIG IPDYCCLGSG
EEEEITINAW FGPPGTVSPL HQDPQQNFLA QVIGRKYIRL YSPQDSEALY PHETHLLHNT
SQVDVENPNL EKFPKFAEAP FLSCILAPGE ILFIPVKYWH YVRALDLSFS VSFWWS
//
