ID H0UZ34_CAVPO Unreviewed; 2581 AA.
AC H0UZ34;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Filamin A {ECO:0000313|Ensembl:ENSCPOP00000002427.3};
GN Name=FLNA {ECO:0000313|Ensembl:ENSCPOP00000002427.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000002427.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000002427.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000002427.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02054556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCPOT00000002706.3; ENSCPOP00000002427.3; ENSCPOG00000002672.4.
DR VEuPathDB; HostDB:ENSCPOG00000002672; -.
DR GeneTree; ENSGT00940000153588; -.
DR HOGENOM; CLU_000783_0_0_1; -.
DR TreeFam; TF313685; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000002672; Expressed in uterine cervix and 12 other cell types or tissues.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21308; CH_FLNA_rpt1; 1.
DR CDD; cd21312; CH_FLNA_rpt2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 24.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537:SF18; FILAMIN-A; 1.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 24.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 24.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 24.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 19..125
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 142..245
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 252..350
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 352..450
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 451..546
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 547..639
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 643..739
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 740..842
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 843..941
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 942..1037
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1038..1130
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1131..1225
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1226..1325
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1326..1418
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1419..1515
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1516..1612
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1613..1708
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1704..1796
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1796..1888
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1886..1975
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1978..2070
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2068..2166
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2169..2261
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2263..2356
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2360..2452
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2486..2580
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 247..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2581 AA; 274366 MW; 2284A52956C4E80E CRC64;
DAEMPATEKD LAEDAPWKKI QQNTFTRWCN EHLKCVSKRI ANLQTDLSDG LRLIALLEVL
SQKKMHRKHN QRPTFRQMQL ENVSVALEFL DRESIKLVSI DSKAIVDGNL KLILGLIWTL
ILHYSISMPM WDEEEDEEAK KQTPKQRLLG WIQNKLPQLP ITNFSRDWQS GRALGALVDS
CAPGLCPDWD SWDASKPVNN AREAMQQADD WLGIPQVITP EEIVDPNVDE HSVMTYLSQF
PKAKLKPGAP LRPKLNPKKA RAYGPGIEPT GNMVKKRAEF TVETRSAGQG EVLVYVEDPA
GHQEEAKVTA NNDKNRTFSV WYVPEVTGTH KVTVLFAGQH IAKSPFEVYV DKSQGDASKV
TAQGPGLEPS GNIANKTTYF EIFTAGAGIG EVEVMIQDPT GQKGTVETQL EARGDSTYRC
TYQPTMEGTH LVHITFAGVP IPRSPYTVTV GQACNPAACR AVGRGLQPKG VRVKETADFK
VYTKGAGSGE LKVTVKGPKG EERVKQKDLG DGVYGFEYYP SVPGMYTVTI TWGGQNIGRS
PFEVKVGTEC GNQKVRAWGP GLEGGVVGKS ADFVVEAIGD DVGTLGFSVE GPSQAKIECD
DKGDGSCDVR YWPQEPGEYA VHVLCNSEDI RLSPFMADIR EAPQDFYPDR VKARGPGLEK
TGVAVNKPAE FTVDAKLGGK APLRVQVQDN EGCPVEASVK DNGNGTYSCS YVPRKPVKHT
AMVSWGGVSI PNSPFRVNVG AGSHPNKVKV YGPGVAKTGL KAHEPTYFTV DCAEAGQGDV
SIGIKCAPGV VGPAEADIDF DIIRNDNDTF TVKYTPRGAG SYTIMVLFAD QATPTSPIRV
KVEPSHDASK VKAEGPGLSR SGVELAKPTH FTVNAKAAGK GKLDVQFSGP AKGDAVRDMD
IIDHHDNTYT VKYTPVQQGP VGVNVTYGGD PIPKSPFSVG VSPSLDLAKV KVSGLGEKVD
VGRDQEFTVK SKGAGGQGKV ASKIVGPSGT AVPCKVEPGL GADNSVVRFV PREEGPYEVE
VTYDGVPVPG SPFPVEAVAP TKPSKVKAFG PGLQGGSTGS PARFTIDTKG AGTGGLGLTV
EGPCEAQLEC LDNGDGTCSV SYVPTEPGDY NINILFADTH IPGSPFKAHV VPCFDASKVK
CSGPGLERAT AGEVGQFQVD CSSAGSAELT IEICSEAGLP AEVYIQDHGD GTHTITYIPL
CPGAYTVTIK YGGQPVPNFP SKLQVEPAVD TSGVQCYGPG IEGQGVFREA TTEFSVDARA
LTQTGGPHVK ARVANPSGNL TETYVQDLGD GTYKVEYTPY EEGLHSVDVT YDGSPVPSSP
FQVPVTEGCD PSRVRVHGPG IQSGTTNKPN KFTVETRGAG TGGLGLAVEG PSEAKMSCMD
NKDGSCSVEY IPYEPGTYSL NVTYGGHQVP GSPFKVPVHD VTDASKVKCS GPGLNPGMVR
ANLPQSFQVD TSKAGVAPLQ VKVQGPKGLV EPVDVVDNAD GTQTVNYVPS REGPYSISVL
YGEEEVPRSP FKVKVLPTHD ASKVKASGPG LNTTGVPASL PVEFTIDAKD AGEGLLAVQI
TDPEGKPKKT HIQDNHDGTY TVAYVPDVTG RYTILIKYGG DEIPFSPYRV RAVPTGDASK
CTVTGAGIGP TIQIGEETVI TVDTKAAGKG KVTCTVCTPD GSEVDVDVVE NEDGTFDIFY
TAPQPGKYVI CVRFGGEHVP NSPFQVTAPE RPLVGVNGLD VTSLRPFDLV IPFTIKKGEI
TGEVRMPSGK VAQPSITDNK DGTVTVRYAP SEAGLHEMDI RYDNMHIPGS PLQFYVDYVN
CGHVTAYGPG LTHGVVNKPA TFTVNTKDAG EGGLSLAIEG PSKAEISCTD NQDGTCSVSY
LPVLPGDYSI LVKYNEQHIP GSPFTARVTG DDSMRMSHLK VGSAADIPIN ISETDLSLLT
ATVVPPSGRE EPCLLKRLRN GHVGISFVPK ETGEHLVHVK KNGQHVASSP IPVVISQSEI
GDASRVRVSG QGLHEGHTFE PAEFIIDTRD AGYGGLSLSI EGPSKVDINT EDLEDGTCRV
SYCPTEPGNY IINIKFADQH VPGSPFSVKV TGEGRVKESI TRRRRAPSVA NVGSHCDLSL
KIPEISIQDM MAQVTSPSGK THEAEIVEGE NHTYCIRFVP AEMGMHTVSV KYKGQHVPGS
PFQFTVGPLG EGGAHKVRAG GPGLERAEAG VPAEFSIWTR EAGAGGLAIA VEGPSKAEIS
FEDRKDGSCG VAYVVQEPGD YEVSVKFNEE HIPDSPFVVP VASPSGDARR LTVSSLQESG
LKVNQPASFA VSLNGAKGAI DAKVHSPSGA LEECYVTEID QDKYAVRFIP RENGIYLIDV
KFNGTHIPGS PFKIRVGEPG HGGDPGLVSA YGPGLEGGVT GSPAEFIVNT SNAGAGALSV
TIDGPSKVKM ECQECPEGYR VTYTPMAPGS YLISIKYGGP YHIGGSPFKA KVTGPRLVSN
HSLHETSSVF VDSLTKAASA PQQGALGPAD ASKVVAKGLG LSKAYMGQKS SFTVDCSKAG
NNMLLVGVHG PRTPCEEILV KHVGSRLYSV SYLLKDKGEY MLVVKWGDEH IPGSPYRVLV
P
//
