ID H0UZN4_CAVPO Unreviewed; 663 AA.
AC H0UZN4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Fermitin family member 3 {ECO:0000313|Ensembl:ENSCPOP00000002651.2};
GN Name=FERMT3 {ECO:0000313|Ensembl:ENSCPOP00000002651.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000002651.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000002651.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000002651.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the kindlin family.
CC {ECO:0000256|ARBA:ARBA00008052}.
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DR EMBL; AAKN02038519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003468180.1; XM_003468132.3.
DR AlphaFoldDB; H0UZN4; -.
DR STRING; 10141.ENSCPOP00000002651; -.
DR Ensembl; ENSCPOT00000002955.3; ENSCPOP00000002651.2; ENSCPOG00000002919.4.
DR GeneID; 100719497; -.
DR KEGG; cpoc:100719497; -.
DR CTD; 83706; -.
DR VEuPathDB; HostDB:ENSCPOG00000002919; -.
DR eggNOG; KOG3727; Eukaryota.
DR GeneTree; ENSGT00390000013444; -.
DR HOGENOM; CLU_011611_0_0_1; -.
DR InParanoid; H0UZN4; -.
DR OMA; RWLLQTH; -.
DR OrthoDB; 5399911at2759; -.
DR TreeFam; TF314677; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000002919; Expressed in liver and 12 other cell types or tissues.
DR GO; GO:0002102; C:podosome; IEA:Ensembl.
DR GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR GO; GO:0033622; P:integrin activation; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0007159; P:leukocyte cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0070527; P:platelet aggregation; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0033632; P:regulation of cell-cell adhesion mediated by integrin; IEA:Ensembl.
DR GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Ensembl.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13205; FERM_C_fermitin; 1.
DR CDD; cd17185; FERM_F1_KIND3; 1.
DR CDD; cd01237; PH_fermitin; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR037843; Kindlin/fermitin.
DR InterPro; IPR040790; Kindlin_2_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037837; PH_Kindlin/fermitin.
DR PANTHER; PTHR16160; FERMITIN 2-RELATED; 1.
DR PANTHER; PTHR16160:SF1; FERMITIN FAMILY HOMOLOG 3; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF18124; Kindlin_2_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 357..453
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 663 AA; 75332 MW; 719BB45AE6CDA4A3 CRC64;
MAGMKTATGD YIDSSWELRV FVGEEDPEAQ SVTLRVTGES HIGGVLLKIV EEINRKQDWS
DHAIWWEQKR QWLLQTHWTL DKYGILADAR LFFGPQHRPV TLRLPNRRAL RLRASFSKPL
FKAVADVCRL LSIRHPEELS LLRDPEKKEK KKKEKEPEEE VFDLTKVVLA GGVAPVLFRG
MPAHFSDSAH TEACFHMLSR PQPPPDPGLL QRLPRPGSLA DKTQLHSRWL DSSRCLMQQG
IKAGDTLWLR FKYYSFFDLD PKADQVRLMQ LYEQARWDLL LEEIDCTEAE MMMFAALQYH
INKLSQSGEA GEVASTDPGL DDLDAALNNL EVKLEGSAPT DVLDSLTTIP ELKDHLRIFR
PRKLTLKGYR QHWVVFKETT LSYYKSQDEA PGDPIQQLNL KGCEVAPDVN VSSQKFCIKL
LVPSPEGMSE IYLRCQDEQQ YAQWMAGCRL ASKGRTMADS SYASEVQAIL AFLSLQQAGG
GGSGNHTQGP EASAEGLNPY GLVAPRFQRK FKAKQLTPRI LEAHQNVAQL SLTEALLRFI
QAWQSLPDFG ISYFMVRFKG SKKDEILGIA NNRLIRIDLA VGDVVKTWRF SNMRQWNVNW
DIRQVAIEFD EHINVAFSCV SASCRIVHEY IGGYIFLSTR ERAHGEEQNE DLFLQLTGGH
EAF
//
