ID H0UZN9_CAVPO Unreviewed; 836 AA.
AC H0UZN9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Ataxin 7 {ECO:0000313|Ensembl:ENSCPOP00000002656.3};
GN Name=ATXN7 {ECO:0000313|Ensembl:ENSCPOP00000002656.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000002656.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000002656.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000002656.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02001472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02001473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0UZN9; -.
DR STRING; 10141.ENSCPOP00000002656; -.
DR Ensembl; ENSCPOT00000002960.3; ENSCPOP00000002656.3; ENSCPOG00000002924.4.
DR VEuPathDB; HostDB:ENSCPOG00000002924; -.
DR eggNOG; KOG4140; Eukaryota.
DR GeneTree; ENSGT00940000157279; -.
DR HOGENOM; CLU_014451_1_0_1; -.
DR InParanoid; H0UZN9; -.
DR OMA; NNVHTKH; -.
DR TreeFam; TF331337; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000002924; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0007026; P:negative regulation of microtubule depolymerization; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR Gene3D; 6.10.140.670; -; 1.
DR InterPro; IPR013243; SCA7_dom.
DR PANTHER; PTHR15117; ATAXIN 7 RELATED; 1.
DR PANTHER; PTHR15117:SF2; ATAXIN-7; 1.
DR Pfam; PF08313; SCA7; 1.
DR PROSITE; PS51505; SCA7; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 292..359
FT /note="SCA7"
FT /evidence="ECO:0000259|PROSITE:PS51505"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..438
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 836 AA; 89197 MW; ED08A25956A14A25 CRC64;
MSERAADDVR GEPRRAAAGG AAARQPPQPP RQRPRPEDGG PGSAATAAAM ATAGERRPLP
SPEAMLGQSW NLWVEEFGKN REVMGLCRED MPIFGLCPAH DDFYLVVCND CNQVVKPQAF
QSHYERRHSS SNKPSLAVPP ASVFPFFPSL SKSKGGSASG SSRSSSGAAV SASSSSSRSL
KSPKEKPQLR GNTRPMHPIQ QSRGPHGRIM TPSVKVEKIH PKMDGTLLKP AVGPTCPATV
SSSVKPGLNC PSIPKPTLPS PGQILNGKGL PAPPTLEKKS EDSSNNKKFL NKRLSEREFD
PDIHCGVIDL DTKKPCTRSL TCKTHSLTQR RAVQGRRKRF DVLLAEHKNK TREKESIRHL
DSQQPLQPLR DPHPAPPRLS QEPHHMTPSE SKPFVASKPK PHTPSLPRPP GCPAQQSGSA
PIDPPPVHES PHPPLPASEP ASRLSSEEGE GDDKEESVEK LDCHYSGHHP QPASFCTFGS
RQIGRGYYVF DSRWNRLRCA ISLMVEKHLN SQLWKKIPPV PSTTSPVSMR APHRTNSVPT
SQGGVSYLSA ATVSASPVLL SSACISPNSK SVPAHGTTLN AQPTASGAMD PVCGMQSRQV
SSSSSSPSTP SGLSSVPSSP MSRKPQKLKS SKSLRPKESS GNSTNCHNAS SSNSGGSGKK
RKNSSPLLVH SSSSSSSSSH SMESFRKNCV AHSGSPYPST VTSSHGLGLS CVTNRTHPGS
LRHEQSGRGP PGGSPTESIK RMSVMVNSSD STLSLGPFVH QASELFSHSH TPLDKLIGKK
RKCTPGSSSI NNSSSKPTKV AKLPPMNNVH MKHTGTIPGA QGLTNSSLLH QPKARP
//
