ID H0UZX2_CAVPO Unreviewed; 360 AA.
AC H0UZX2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPN7 {ECO:0000313|Ensembl:ENSCPOP00000002748.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000002748.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000002748.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000002748.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02017947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013013583.1; XM_013158129.1.
DR AlphaFoldDB; H0UZX2; -.
DR STRING; 10141.ENSCPOP00000002748; -.
DR Ensembl; ENSCPOT00000003074.3; ENSCPOP00000002748.2; ENSCPOG00000003034.4.
DR GeneID; 100723664; -.
DR KEGG; cpoc:100723664; -.
DR CTD; 5778; -.
DR VEuPathDB; HostDB:ENSCPOG00000003034; -.
DR eggNOG; KOG0789; Eukaryota.
DR GeneTree; ENSGT00940000160979; -.
DR HOGENOM; CLU_001645_10_3_1; -.
DR InParanoid; H0UZX2; -.
DR OMA; GYDGREK; -.
DR OrthoDB; 2914248at2759; -.
DR TreeFam; TF331016; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000003034; Expressed in testis and 3 other cell types or tissues.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14612; PTPc-N7; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR008356; Tyr_Pase_KIM-con.
DR PANTHER; PTHR46198; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR PANTHER; PTHR46198:SF3; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR01778; KIMPTPASE.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 97..350
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 268..341
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT ACT_SITE 291
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR608356-50"
FT BINDING 257
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR608356-51"
FT BINDING 291..297
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR608356-51"
FT BINDING 335
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR608356-51"
SQ SEQUENCE 360 AA; 40424 MW; CE2B689563F8E896 CRC64;
MVQAFGGCSL QQSTALSLGA AMTQPPPTKA PPKKHVRLQE RRGSNVALML DVRSLGTVEP
ICSVNTPREV TLHFLRTAGR PLTCWALRHQ PPSPKQLEEE FLKIPSNFVS PEDLDIPGHA
SKDRYKTILP NPQSRVCLGR AQSQEDGDYI NANYIRGYDG QEKVYIATQG PMPNTMSDFW
EMVWQEDVCL IVMLTQLREG KEKCVHYWPT EEETYGPFRI RVQDTKERPE YTVRQLTIQH
QEECRSVKHI LFSAWPDHQT PESAGPLLRL VAEVDESPET AANTGPIVVH CSAGIGRTGC
FIATRIGCQQ LKAQGEVDIL GIVCQLRLDR GGMIQTSEQY QFLHHTLALY AAQLPQEPRA
//
