ID H0V0L3_CAVPO Unreviewed; 1232 AA.
AC H0V0L3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=USP40 {ECO:0000313|Ensembl:ENSCPOP00000003004.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000003004.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000003004.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000003004.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR EMBL; AAKN02019311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02019312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02019313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02019314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005005764.1; XM_005005707.2.
DR RefSeq; XP_013012852.1; XM_013157398.1.
DR AlphaFoldDB; H0V0L3; -.
DR STRING; 10141.ENSCPOP00000003004; -.
DR Ensembl; ENSCPOT00000003367.3; ENSCPOP00000003004.3; ENSCPOG00000003324.4.
DR GeneID; 100721912; -.
DR KEGG; cpoc:100721912; -.
DR CTD; 55230; -.
DR VEuPathDB; HostDB:ENSCPOG00000003324; -.
DR eggNOG; KOG1863; Eukaryota.
DR GeneTree; ENSGT00940000157267; -.
DR HOGENOM; CLU_009719_0_0_1; -.
DR InParanoid; H0V0L3; -.
DR OMA; PEGSHWF; -.
DR OrthoDB; 51419at2759; -.
DR TreeFam; TF106281; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000003324; Expressed in pituitary gland and 12 other cell types or tissues.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF842; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 40; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 41..479
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 943..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1202..1232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1232 AA; 138163 MW; 8E6D5EC99ED3A6E3 CRC64;
MFGDLFEEDY SSVSDNQYGK GKKLKTKPLE LPAPREFTNL SGIRNQGGTC YLNSLLQTLH
FTPEFREALF SLGPAELGSL EDKDKPDAKV RIIPLQLQRL FAQLLLLDQE AASTADLTDS
FGWTSNEEMR QHDVQELNRI LFSALETSLV GTSGHDLINR LYHGTVVNQI VCKECKNISE
KQEDFLDLTV AVKDVSGLED ALWSMYVEEE VFDCDNLYHC GTCDRLVTAT KSAKLRKLPP
FLTVSLLRFN FDFVKCERYK ETSCYTFPLR INLKPFCEQS ELNDLDYVYD LFSVIIHKGG
CYGGHYHVYI KDVDHLGNWQ FQEPDMSLKA LQNEEDIDDP LTVLKALLQQ EENNLIPVDQ
LGQKLLKKIG ISWNKKYKKQ HGPLLKFLQV HSQTFLLNSD ASTVSLQKKF SLQAGSGYQS
NGQQILQMHP SKPPGSNDSP TCPHWFDIND SKVQPIKEKD IEQQFQGKES AYMLFYRKSQ
LQRPLEARAN PRYRVPCHLL KEMDAANMEL QMKRAECDSA NNNIDLHLHM GPHYHFFNGA
LHPVSCQTES VWDLTFDKRK TLGDLQQSIF QLLEFWEGDI VLSVAKRVPA GLHVYQALNG
NELTLYEVGI ADGEDIFVWN GVEVGGVQIP TGVDCEPLLL HILHLETSGD GQSCEQLVEA
PHIFPANAAV STVLTALALP EGVIFTHSAW SAGEASWTPI SQEDMQRTFR EHGLKDGSSV
LVQDSYSGDN SVLPQGGNWI PGMREVDWLE VKNLCQLESG EKRVKIVAAA NTVVFDIRIK
AIKELKLMTE LVENSCLRPI DRHGKLLHPV PDSSTLKEAE VKLGSSLGLC LGKAPTSSQL
FLFFALGSDI QPGTEMEVIV EETLSVRDCL KIMLEKSGLP GDGWHLRKMD WCYEAGEPLC
EEDVTLKELM ICSGDTLLLI EGKLPPPGFL KVPIWWHQPQ GPSGCWESRD QPHSSPAEGG
SWRAAATQGV PGHVPAEVPL LFLGDLDISE DARLLDLKSQ ARALPPASEL AVPGPALLRA
WTLENKRPGR LLRANRQQLK EYKLGRRAAI CLEPLQKEEH LGPQEVLLRT QMRIPGQRLY
APAVDLVWDT ARGSTAGALR QRVADCYALP VEKIEIAKYF PEKFEWLPIS SWNQQVTRKK
KKKKQDNLQG APYYLKDGDT IGIKNLLVDD NEDFSTIRDD IGKENLKQQA LGKRLSREAL
RAQSGDMLSS SGTPARPRGP EAALSIHVGS FR
//
