ID H0V1F1_CAVPO Unreviewed; 432 AA.
AC H0V1F1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Milk fat globule-EGF factor 8 protein {ECO:0000313|Ensembl:ENSCPOP00000003314.3};
GN Name=MFGE8 {ECO:0000313|Ensembl:ENSCPOP00000003314.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000003314.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000003314.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000003314.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AAKN02016041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003475299.1; XM_003475251.3.
DR AlphaFoldDB; H0V1F1; -.
DR STRING; 10141.ENSCPOP00000003314; -.
DR Ensembl; ENSCPOT00000003717.3; ENSCPOP00000003314.3; ENSCPOG00000003673.4.
DR GeneID; 100729745; -.
DR KEGG; cpoc:100729745; -.
DR CTD; 4240; -.
DR VEuPathDB; HostDB:ENSCPOG00000003673; -.
DR eggNOG; ENOG502QVK3; Eukaryota.
DR GeneTree; ENSGT00940000156049; -.
DR HOGENOM; CLU_030066_0_1_1; -.
DR InParanoid; H0V1F1; -.
DR OMA; YVKTFKV; -.
DR OrthoDB; 3043281at2759; -.
DR TreeFam; TF330156; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000003673; Expressed in uterine cervix and 13 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR GO; GO:0001786; F:phosphatidylserine binding; IEA:Ensembl.
DR GO; GO:0043277; P:apoptotic cell clearance; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00057; FA58C; 2.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR46806:SF10; EGF-LIKE REPEAT AND DISCOIDIN I-LIKE DOMAIN-CONTAINING PROTEIN 3 PRECURSOR; 1.
DR PANTHER; PTHR46806; F5/8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF00754; F5_F8_type_C; 2.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00231; FA58C; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01285; FA58C_1; 2.
DR PROSITE; PS01286; FA58C_2; 2.
DR PROSITE; PS50022; FA58C_3; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..432
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011677409"
FT DOMAIN 24..62
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 65..109
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 111..268
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 273..432
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DISULFID 33..50
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 52..61
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 99..108
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 432 AA; 47436 MW; 653184E6705294E6 CRC64;
MQGPRVLAAL CGALLCASGL LAASGDFCDS SICLNGGTCL FGQDSVSSYC LCPEGFTGLL
CNETEKGPCS PNPCYHNAGC QVIDSSHRGD VFTPYICDCP PGYAGIHCET TCNRGLGMEE
GIIVDSQISA SSLYIGFLGL QRWGPELARL HRSGIVNAWT ASNYDRKPWI QVNLLRKMRV
TGVVTQGASR AGSAEYVKTF KVAYSLDGRK FQFIQNEEDS GDKVFTGNMN NNGLKLNMFS
APLEVQYVRL YPVACYRGCT LRFELLGCEL NGCSEPLGLK DGSIPNRQIT ASSSYKTWGL
PMFNWLPFLG RLDNRGKINA WTAQSNSPNA SEWLQVDLGS KKQVTGIITQ GARDFGHIQY
VASYKVAYSD NGISWTEYKE PGAVDSKIFR GNLDNNSHKK NVFETPFSAR YVRVLPVSWQ
NRITLRLELL GC
//