ID H0V1Q0_CAVPO Unreviewed; 665 AA.
AC H0V1Q0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Rho GTPase activating protein 18 {ECO:0000313|Ensembl:ENSCPOP00000003428.3};
GN Name=ARHGAP18 {ECO:0000313|Ensembl:ENSCPOP00000003428.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000003428.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000003428.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000003428.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02038160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02038161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013006494.1; XM_013151040.1.
DR AlphaFoldDB; H0V1Q0; -.
DR STRING; 10141.ENSCPOP00000003428; -.
DR Ensembl; ENSCPOT00000003842.3; ENSCPOP00000003428.3; ENSCPOG00000003798.4.
DR GeneID; 100729447; -.
DR KEGG; cpoc:100729447; -.
DR CTD; 93663; -.
DR VEuPathDB; HostDB:ENSCPOG00000003798; -.
DR eggNOG; KOG2200; Eukaryota.
DR GeneTree; ENSGT00940000157142; -.
DR HOGENOM; CLU_023268_2_1_1; -.
DR InParanoid; H0V1Q0; -.
DR OMA; QHNMESQ; -.
DR OrthoDB; 11483at2759; -.
DR TreeFam; TF314044; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000003798; Expressed in thyroid gland and 13 other cell types or tissues.
DR GO; GO:0005881; C:cytoplasmic microtubule; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:2000145; P:regulation of cell motility; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:Ensembl.
DR CDD; cd04391; RhoGAP_ARHGAP18; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF6; RHO GTPASE-ACTIVATING PROTEIN 18; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 326..525
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 14..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 665 AA; 74917 MW; 1FF28836455CE921 CRC64;
MSWLSSSQGV VLTAYHPSSK DQAVGDSHAK QGEESISSSS CRYGQYTMSQ GSTTKATEKP
PFDRSSSQDS LDEMSMEDYW TELENIKKSS ENRQAQEVVV VKIPDEGELE EEWLKEAGLS
NLFGESAEDP QESMVFLSTL TRTQAAAVQK RVETVSQTLR KKNKQYHIPD VRDIFAQQTE
LKEKAPDGPE LQSVGTNENK YQEKDGQASC LAGDKQLILP VPEDTPTSIT DINLEVSFAE
QAFNQKQNSK DKIQKTKGSD ASLPSFRLPK DKTGTTKMGD LAPQDMKKVC YLAFIELTAL
YDVLGLELKQ QKAVKIKTRD SGLFGVSLTM LLEKDQRTVP GTRIPLIFQK LISRIEEGGL
DTEGLLRIPG AAVRIKNLCQ ELEAKFYEGT FNWENVKQHD AASLLKLFIR ELPQPLLSVE
YLKAFQAVQN LPTKKHQLQA LNLLIILLPD ANRDTLKALL EFLQRVIDNK EKNKMTVMNV
AMVMAPNLFM CHALGLKSSE QREFVMAAET ASIMHLLIKY QKLLWTIPKF IVTQVRKQNT
ESQKKDKKPM KKLLKKMAYD REKYEKQDKS TNDADVPQGV IRVQAPHLSK VSMAIQLTEE
LKASDVLARF LSQESGVAQT LKKGEVFLYE IGGNIGERCL DDDTYMQDLY QLNPNAEWVI
KSKPS
//
