ID H0V1W7_CAVPO Unreviewed; 397 AA.
AC H0V1W7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Solute carrier family 39 member 8 {ECO:0000313|Ensembl:ENSCPOP00000003505.3};
GN Name=SLC39A8 {ECO:0000313|Ensembl:ENSCPOP00000003505.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000003505.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000003505.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000003505.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR EMBL; AAKN02038761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02038762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0V1W7; -.
DR STRING; 10141.ENSCPOP00000003505; -.
DR Ensembl; ENSCPOT00000003927.3; ENSCPOP00000003505.3; ENSCPOG00000003883.4.
DR VEuPathDB; HostDB:ENSCPOG00000003883; -.
DR GeneTree; ENSGT00940000158926; -.
DR HOGENOM; CLU_015114_13_0_1; -.
DR InParanoid; H0V1W7; -.
DR OMA; ITMFAGE; -.
DR TreeFam; TF318470; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000003883; Expressed in adult mammalian kidney and 13 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0140412; F:zinc:bicarbonate symporter activity; IEA:Ensembl.
DR GO; GO:0006525; P:arginine metabolic process; IEA:Ensembl.
DR GO; GO:0070574; P:cadmium ion transmembrane transport; IEA:Ensembl.
DR GO; GO:1990079; P:cartilage homeostasis; IEA:Ensembl.
DR GO; GO:0098849; P:cellular detoxification of cadmium ion; IEA:Ensembl.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0030026; P:intracellular manganese ion homeostasis; IEA:Ensembl.
DR GO; GO:0006882; P:intracellular zinc ion homeostasis; IEA:Ensembl.
DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:0061757; P:leukocyte adhesion to arterial endothelial cell; IEA:Ensembl.
DR GO; GO:0015694; P:mercury ion transport; IEA:Ensembl.
DR GO; GO:1990540; P:mitochondrial manganese ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0097080; P:plasma membrane selenite transport; IEA:Ensembl.
DR GO; GO:0006487; P:protein N-linked glycosylation; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR GO; GO:0071578; P:zinc ion import across plasma membrane; IEA:Ensembl.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR12191:SF2; METAL CATION SYMPORTER ZIP8; 1.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR Pfam; PF02535; Zip; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 119..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 397 AA; 42001 MW; 7C0F39639B031B1D CRC64;
LLLLAAPALG AQAPTRAFSE DVLSTFGANL SLSAAQLGLL FGELGAGHGG HAGATAPGAL
HFNQCLSAEE IFALHGFSNA SRITSADFPS ICPAVLQQLT FHPCEAQPRP SSKPSLSQVW
GYGLLSVTII NLASLLGLVL TPLLKKSYFP KILTYFVGLA IGTLFSNAIF QLIPEVRMCH
SLSLLAAPAS LPLSAFSPLP LTLPLPASQI LSRKSLLPGK KESSSSGCLK GPKLSEIGTI
AWMITLCDAL HNFIDGLAIG ASCTLSLLQG LSTSIAILCE EFPHELGDFV ILLNAGMSTR
QALLFNFLSA CSCYVGLAFG ILVGNNFAPN IIFALAGGMF LYISLADMFP EMNDMLREKV
TGRKKDFTFF LIQNAGMLTG FTAILLITLY AGDIELE
//
