GenomeNet

Database: UniProt
Entry: H0V291_CAVPO
LinkDB: H0V291_CAVPO
Original site: H0V291_CAVPO 
ID   H0V291_CAVPO            Unreviewed;       570 AA.
AC   H0V291;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   24-JAN-2024, entry version 73.
DE   SubName: Full=Regulator of G protein signaling 14 {ECO:0000313|Ensembl:ENSCPOP00000003641.3};
GN   Name=RGS14 {ECO:0000313|Ensembl:ENSCPOP00000003641.3};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000003641.3, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000003641.3}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000003641.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC       {ECO:0000256|ARBA:ARBA00004279}.
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DR   EMBL; AAKN02022925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005005238.1; XM_005005181.2.
DR   AlphaFoldDB; H0V291; -.
DR   STRING; 10141.ENSCPOP00000003641; -.
DR   Ensembl; ENSCPOT00000004080.3; ENSCPOP00000003641.3; ENSCPOG00000004036.4.
DR   GeneID; 100728156; -.
DR   KEGG; cpoc:100728156; -.
DR   CTD; 10636; -.
DR   VEuPathDB; HostDB:ENSCPOG00000004036; -.
DR   eggNOG; KOG3589; Eukaryota.
DR   GeneTree; ENSGT00940000161364; -.
DR   HOGENOM; CLU_024780_1_1_1; -.
DR   InParanoid; H0V291; -.
DR   OMA; SQGCLPR; -.
DR   OrthoDB; 22856at2759; -.
DR   TreeFam; TF328814; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000004036; Expressed in frontal cortex and 10 other cell types or tissues.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0043197; C:dendritic spine; IEA:Ensembl.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR   GO; GO:0005819; C:spindle; IEA:Ensembl.
DR   GO; GO:0001965; F:G-protein alpha-subunit binding; IEA:InterPro.
DR   GO; GO:0005092; F:GDP-dissociation inhibitor activity; IEA:Ensembl.
DR   GO; GO:0032794; F:GTPase activating protein binding; IEA:Ensembl.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR   GO; GO:0007059; P:chromosome segregation; IEA:Ensembl.
DR   GO; GO:0007612; P:learning; IEA:Ensembl.
DR   GO; GO:0007616; P:long-term memory; IEA:Ensembl.
DR   GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045744; P:negative regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0031914; P:negative regulation of synaptic plasticity; IEA:Ensembl.
DR   GO; GO:0006913; P:nucleocytoplasmic transport; IEA:Ensembl.
DR   GO; GO:0043620; P:regulation of DNA-templated transcription in response to stress; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0007051; P:spindle organization; IEA:Ensembl.
DR   GO; GO:0010070; P:zygote asymmetric cell division; IEA:Ensembl.
DR   CDD; cd17137; RBD1_RGS14; 1.
DR   CDD; cd08743; RGS_RGS14; 1.
DR   Gene3D; 1.10.196.10; -; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003109; GoLoco_motif.
DR   InterPro; IPR046992; RBD1_RGS14.
DR   InterPro; IPR003116; RBD_dom.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR046995; RGS10/12/14-like.
DR   InterPro; IPR037881; RGS14_RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR024066; RGS_subdom1/3.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR45945:SF2; REGULATOR OF G-PROTEIN SIGNALING 14; 1.
DR   PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR   Pfam; PF02196; RBD; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00390; GoLoco; 1.
DR   SMART; SM00455; RBD; 2.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 2.
DR   PROSITE; PS50898; RBD; 2.
DR   PROSITE; PS50132; RGS; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT   DOMAIN          67..184
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          305..376
FT                   /note="RBD"
FT                   /evidence="ECO:0000259|PROSITE:PS50898"
FT   DOMAIN          378..448
FT                   /note="RBD"
FT                   /evidence="ECO:0000259|PROSITE:PS50898"
FT   REGION          23..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          191..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          460..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          534..570
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        537..570
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   570 AA;  62059 MW;  E9722788D8B2C6AE CRC64;
     MPGKPKHLGV PNGRMVLAVS DGELSSTAGS QAQGEGRGSS LSIHSLPSGP SSPFTTEEQP
     VASWALSFER LLQDPLGLAY FTEFLKKEFS AENVTFWMAC ERFQQIPASN TEQLAQEARN
     IYEEFLSSQA LSPVNIDRQA WLGEEVLAQP RPDMFRAQQL QIFNLMKFDS YARFVKSPLY
     RECLLAEAEG RPLREPGSSS LGSPDTTRKK PKLKPGKSLP LGVEELGHLP LPEGPGGRPL
     RKSFRRELDG KATNLALRRE SQGSLNSSAS LDLGFLAFIS NKSESQSHRK SLGSTEGETE
     SRPGKYCCVY LPDGTASLAL ARPGLTIRDM LAGICEKRGL SLPDIKVYLV GNEQKPLVLD
     QDCTVLADQE VRLENRITFE LELVALERVV RISAKPTKRL HEALQPILAK HGLSLEQVAL
     HRPGETQLLD LEKLVSSVAA QRLVLDTLPG AKICEASNIT PCSNQGHTPK TKDKATHLPP
     QPPASLLQVP SSATGKRQTC DIEGLVELLN RVQSCGAHDQ RGLLRKEDLV LPEFLQLPAQ
     QPSSPEAPPQ TNSAAQPSGG PLDSTTHPAV
//
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