ID H0V2B7_CAVPO Unreviewed; 997 AA.
AC H0V2B7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=General transcription factor IIi {ECO:0000313|Ensembl:ENSCPOP00000003673.3};
GN Name=GTF2I {ECO:0000313|Ensembl:ENSCPOP00000003673.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000003673.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000003673.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000003673.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AAKN02056569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02056570; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0V2B7; -.
DR Ensembl; ENSCPOT00000004116.3; ENSCPOP00000003673.3; ENSCPOG00000004071.4.
DR VEuPathDB; HostDB:ENSCPOG00000004071; -.
DR GeneTree; ENSGT00940000160349; -.
DR HOGENOM; CLU_011773_0_0_1; -.
DR OMA; TEAWNAK; -.
DR TreeFam; TF352524; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000004071; Expressed in pituitary gland and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 3.90.1460.10; GTF2I-like; 6.
DR InterPro; IPR004212; GTF2I.
DR InterPro; IPR036647; GTF2I-like_rpt_sf.
DR InterPro; IPR016659; TF_II-I.
DR PANTHER; PTHR46304:SF2; GENERAL TRANSCRIPTION FACTOR II-I; 1.
DR PANTHER; PTHR46304; GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF02946; GTF2I; 6.
DR PIRSF; PIRSF016441; TF_II-I; 1.
DR SUPFAM; SSF117773; GTF2I-like repeat; 6.
DR PROSITE; PS51139; GTF2I; 6.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT REGION 210..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..676
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 959..973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 997 AA; 112371 MW; 3FF1A059D816DD2E CRC64;
MAQVAMSTLP IEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE
RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTAQAN RMSVDAVEIE TLRKTVEDYF
CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPENYDLATL KWILENKAGI
SFIIQRKPQC NFSLLFVGGR VMVTDTERSI MSPSGSCGPV KVKTEPTEDS GISLEMAAVT
VKEESEDPDY YQYNIQGPSE TDDVDEKLPL SKPLQGSRHS SEGNEGAEVE VPAEDSTQHV
PSETSEDPEV EVTIEDDDYS PPTKRPKSSE PPQPPVAEPA NAGKRKVREF NFEKWNARIT
DLRKQVEELF ERKYAQAIKA KGPVTIPYPL FQSHVEDLYV EGLPEGIPFR RPSTYGIPRL
ERILLAKERI RFVIKKHELL NSTREDLQLD KPASGVKEEW YARITKLRKM VDQLFCKKFA
EALGSTEAKA VPYQKFEAHP NDLYVEGLPE NIPFRSPSWY GIPRLEKIIQ VGNRIKFVIK
RPELLTHSTT EVTQPRTNTP VKEDWNVRIT KLRKQVEEIF NLKFAQALGL TEAVKVPYPV
FESNPEFLYV EGLPEGIPFR SPTWFGIPRL ERIVRGSNKI KFVVKKPELV VSYLPPGMAS
KINTKALQSP KRPRSPGSNS KVPEIEVTVE GPNNNNPQTS TVRTPTQTNG SNVPFKPRGR
EFSFEAWNAK ITDLKQKVEN LFNEKCGEAL GLKQAVKVPF ALFESFPEDF YVEGLPEGVP
FRRPSTFGIP RLEKILRNKA KIKFIIKKPE MFETAIKEST SSKSPPRKIN SSPSVNTTAS
GVEDLNIIQV TIPDDDNERL SKVEKARQLR EQVNDLFSRK FGEAIGMGFP VKVPYRKITI
NPGCVVVDGM PPGVSFKAPS YLEISSMRRI LDSAEFIKFT LLPEFTALFS ELVDQNESEG
PVIQESAEST QLEVPPTEEI KETEGSSQIK QEPDPTW
//
