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Database: UniProt
Entry: H0V396_CAVPO
LinkDB: H0V396_CAVPO
Original site: H0V396_CAVPO 
ID   H0V396_CAVPO            Unreviewed;       588 AA.
AC   H0V396;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   16-JAN-2019, entry version 49.
DE   SubName: Full=Galactosidase beta 1 {ECO:0000313|Ensembl:ENSCPOP00000004051};
GN   Name=GLB1 {ECO:0000313|Ensembl:ENSCPOP00000004051};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000004051};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000004051}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000004051};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000004051}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000004051};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|SAAS:SAAS00534244}.
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DR   EMBL; AAKN02022493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02022494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02022495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_013011871.1; XM_013156417.1.
DR   ProteinModelPortal; H0V396; -.
DR   STRING; 10141.ENSCPOP00000004051; -.
DR   Ensembl; ENSCPOT00000004540; ENSCPOP00000004051; ENSCPOG00000004491.
DR   eggNOG; KOG0496; Eukaryota.
DR   eggNOG; COG1874; LUCA.
DR   GeneTree; ENSGT00390000006586; -.
DR   InParanoid; H0V396; -.
DR   TreeFam; TF314816; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000004491; Expressed in 3 organ(s), highest expression level in liver.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0044262; P:cellular carbohydrate metabolic process; IEA:Ensembl.
DR   Gene3D; 2.60.120.260; -; 2.
DR   InterPro; IPR026283; B-gal_1-like.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 2.
DR   Pfam; PF13364; BetaGal_dom4_5; 1.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PIRSF; PIRSF006336; B-gal; 2.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Glycosidase {ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00108869};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    588       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5011596659.
FT   DOMAIN       40    247       Glyco_hydro_35. {ECO:0000259|Pfam:
FT                                PF01301}.
FT   DOMAIN      476    545       BetaGal_dom4_5. {ECO:0000259|Pfam:
FT                                PF13364}.
SQ   SEQUENCE   588 AA;  66175 MW;  F3A9BD925885FFCF CRC64;
     MVAWRVAVHA LALLLLLGSA HGLRNATQRM FEIDYSRDCF LKDGQPFRYI SGSIHYSRVP
     RFYWADRLLK MKMAGLNAIQ TYVPWNFHEP QPGHYEFSGD HDVEYFLQLA HKLGLLVILR
     PGPYICAEWD MGGLPAWLLE KQSIVLRSSD PDYLASVDKW LGVLLPKMKP LLYQNGGPII
     TVQVENEYGS YFACDYNYLR FLQKHFHYHL GDDVLLFTTD GPRQEYLRCG TLQGLYATVD
     FGVGANTPYA AQPTSYDYDA PLSEAGDLTE KYFAVRSVIQ KFEKVPEGII PPSTPKFAYG
     KVALRKLKTV EGALDILCTR GSMKSVYPLT FIQVKQYFGF VLYRTTIPED CGNSTRLSSL
     PLNGVHDRAY VAVDGAPQGV LERSRVLSLN IQGKPGANLD LLVENMGRVN YGRYINDSKG
     LVSNMTLGFH ILTNWTVFPL DTEVAVRSHL GSWANHDADL HDKRCVHGSS NYTLPAFYVG
     NFSIPSEIPD LPQDTFIQFP GWTKGQVWIN GFNLGRYWPA RGPQMTLFVP RHILTTSAPN
     NITVLELERA PCSSCSPELC AVELVDQPVI GAPVVHSHHQ PWFIKTRG
//
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