ID H0V3U1_CAVPO Unreviewed; 204 AA.
AC H0V3U1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Connexin T {ECO:0000313|EMBL:VZP20228.1};
DE SubName: Full=Gap junction protein epsilon 1 {ECO:0000313|Ensembl:ENSCPOP00000004261.3};
GN Name=GJE1 {ECO:0000313|Ensembl:ENSCPOP00000004261.3};
GN Synonyms=CXNT {ECO:0000313|EMBL:VZP20228.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000004261.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|EMBL:VZP20228.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1038/s41598-019-53458-x;
RA Premzl M.;
RT "Comparative genomic analysis of eutherian connexin genes.";
RL Sci. Rep. 9:16938-16938(2019).
RN [3] {ECO:0000313|Ensembl:ENSCPOP00000004261.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000004261.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AAKN02045740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; LT990428; VZP20228.1; -; Genomic_DNA.
DR RefSeq; XP_003465685.1; XM_003465637.1.
DR STRING; 10141.ENSCPOP00000004261; -.
DR Ensembl; ENSCPOT00000004779.3; ENSCPOP00000004261.3; ENSCPOG00000004729.4.
DR GeneID; 100734979; -.
DR KEGG; cpoc:100734979; -.
DR VEuPathDB; HostDB:ENSCPOG00000004729; -.
DR eggNOG; ENOG502RVMN; Eukaryota.
DR GeneTree; ENSGT01090000260098; -.
DR HOGENOM; CLU_115891_0_0_1; -.
DR OMA; WLQIYLF; -.
DR OrthoDB; 5345894at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR GO; GO:0002088; P:lens development in camera-type eye; IEA:Ensembl.
DR GO; GO:0035265; P:organ growth; IEA:Ensembl.
DR Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 2.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; CONNEXIN; 1.
DR PANTHER; PTHR11984:SF1; GAP JUNCTION EPSILON-1 PROTEIN-RELATED; 1.
DR Pfam; PF00029; Connexin; 2.
DR PRINTS; PR00206; CONNEXIN.
DR SMART; SM01089; Connexin_CCC; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 125..194
FT /note="Gap junction protein cysteine-rich"
FT /evidence="ECO:0000259|SMART:SM01089"
SQ SEQUENCE 204 AA; 23668 MW; E07AC302F6E47E65 CRC64;
MSLNYIKNFY EGCLKPPTVI GQFHTLFFGS VRMFFLGVLG FAVYGNEALH FSCDPDKREI
NLFCYNQFRP ITPQVFWALQ LVIVLVPGAI FHLYAACKSI NQECILQKPI YTVIYILSVL
LRISLEVIAF WLQIHLFGFQ VKALYLCDAT SLGKKMTIIR CMVPEHFEKT IFLIAMYTFT
VITMVLCIGE VFEIIFRRLC FVRQ
//
