ID H0V437_CAVPO Unreviewed; 3887 AA.
AC H0V437;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=A-kinase anchoring protein 9 {ECO:0000313|Ensembl:ENSCPOP00000004367.3};
GN Name=AKAP9 {ECO:0000313|Ensembl:ENSCPOP00000004367.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000004367.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000004367.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000004367.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
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DR EMBL; AAKN02016786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02016787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02016788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02016789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02016790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02016791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02016792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000004367; -.
DR Ensembl; ENSCPOT00000004906.3; ENSCPOP00000004367.3; ENSCPOG00000004854.4.
DR VEuPathDB; HostDB:ENSCPOG00000004854; -.
DR eggNOG; ENOG502QV16; Eukaryota.
DR GeneTree; ENSGT00730000110871; -.
DR HOGENOM; CLU_000187_0_0_1; -.
DR InParanoid; H0V437; -.
DR OMA; HYVAIQL; -.
DR TreeFam; TF105408; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000004854; Expressed in heart left ventricle and 12 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005801; C:cis-Golgi network; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0005795; C:Golgi stack; IEA:Ensembl.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:Ensembl.
DR GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR GO; GO:0051661; P:maintenance of centrosome location; IEA:Ensembl.
DR GO; GO:0007020; P:microtubule nucleation; IEA:Ensembl.
DR GO; GO:0031116; P:positive regulation of microtubule polymerization; IEA:Ensembl.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR GO; GO:0031503; P:protein-containing complex localization; IEA:Ensembl.
DR GO; GO:0098909; P:regulation of cardiac muscle cell action potential involved in regulation of contraction; IEA:Ensembl.
DR GO; GO:1903358; P:regulation of Golgi organization; IEA:Ensembl.
DR GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR InterPro; IPR028745; AKAP9/Pericentrin.
DR InterPro; IPR005539; ELK_dom.
DR InterPro; IPR019528; PACT_domain.
DR PANTHER; PTHR44981:SF1; A-KINASE ANCHOR PROTEIN 9; 1.
DR PANTHER; PTHR44981; PERICENTRIN-LIKE PROTEIN, ISOFORM F; 1.
DR Pfam; PF10495; PACT_coil_coil; 1.
DR SMART; SM01188; ELK; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 441..462
FT /note="ELK"
FT /evidence="ECO:0000259|SMART:SM01188"
FT DOMAIN 633..654
FT /note="ELK"
FT /evidence="ECO:0000259|SMART:SM01188"
FT DOMAIN 663..684
FT /note="ELK"
FT /evidence="ECO:0000259|SMART:SM01188"
FT REGION 33..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1071..1091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1790..1812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3361..3388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3814..3833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 166..250
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 279..475
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 504..644
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 723..802
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 831..890
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 948..989
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1143..1170
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1326..1360
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1571..1641
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1885..1985
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2015..2158
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2183..2407
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2592..2654
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2689..2744
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3109..3164
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3193..3266
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3568..3609
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3633..3660
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1071..1085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3887 AA; 450943 MW; 27F95396B0EA3D22 CRC64;
MEDEERQKKL EAGKAKVGER ESLTFLVQLA QFRQRKAQSD GQNPPRKQKK KRKTSSSKHD
VHSLNIDQPQ SDEMYINSSQ GVGSVLTPES TIKRTLHSGE IIKPEQVFSL EPESEISTTA
DDYSSEVNGC SFLVKTGKPT NLLREEEFGV DDSYSEQSAQ YSQTHLEMME NELAGKQHEI
EELNRELEEM RAAYGTEGLQ QLQEFEAAIK QRDGIITQLT ANLQQARREK DETMREFLEL
TEQSQKLQIQ FQHLQASETL RNSTHSSTAA DLLQAKQQIL THQQQLEEQD HLLEDYQKKK
EDFKMQINVL QEKIKVYEME QDKKVENANK KEIQEKQAII EALSAKVIEE ERKTLELKDK
ITATDKLVGE LQEQVVQKNQ EIKNIKLELT NSKQKERQCS EEIKQLMGTV EELQKRNHKD
SQFEIDTMQR MEQETQRKLE QLRAELDEMY GQQIVQMKQE LIKQHMSQIE ELKTRQKGEM
ETALKSYSNI TINEDQVKLM NVAINELNIK LQDSNSQKEK LKEELGVVSG EKSALQGQLE
DLFEELSFLR DQIQRARQTI AEQESKLNEA HRSLSTVEDL KAEIISASES RKELELKHEA
EVTNYKIKLE MLEKEKNAVL DRMAESQEAE LERLRTQLLF SHEEELSKLK EDLEIEHRIN
TEKLKDNLGI HYKQQIDDLQ NEMSQKIESM QFEKDSLITK QNQLILEISK LKELQQSLVN
SKSEEMTLQI NELQKEIEIL RQEENEKGTL EQEVQELQLK TELLEKQMKE KEDDLQEKFA
QLEAENNILK DEKKALEDML KTYTPTDQEE RLIFIDSTKS KSKDYNWQKE IEILTEENKN
FRQQCIQLSE EIEKQRNIFS FAEKNFEVNY QELQEEYACL LKVKDDLEDC KNKQELEYES
KLKALNEKLH LQRVNPPMVK VKSYIFDDEP LEMGEVVEKD TTELMEKLEV TKREKLELTK
KLSTLSEQLK KKHSEVTILS EEVKSLKHEK EQVLLRCREL EIIVNHNRAE NVNECDVELS
SLKDGVMTRI GKDFGGSGFE MKDFGKESKI VLKNKSPYEI MTIRKESKQD QLFSSPVTNE
TLPEASEPSE NDKFQHELHV LRAEQNDLRL QMEAQRICLS LVYSTHVDQV REHMENEKDK
ALCSLKEELI SVQEEKIKEL QKTHELELQN IKTQETGNEA KPLHRLIGRL QKAVSEECSD
VSKALCNVFR EYYAPTLKCE VNMEERENSG VYPSEYQEPE FQNYIYKVED FQENMQTLLS
KVTEEYNKLL ILQTQLSKVQ EQQTDGVKFE FTKENLSKEE TESLSIHSQM TSLQNIDVNH
KSTLSSLQDT EKVKHLKEQV QDLENLVSSL QRQLKKKEEN YGVENQILQE KLQTVSESTV
HPSIDSAAVK ASAGQRTEHT GYCLKENIDG TIEFSGEFGM KQEANTVTLL EKQYQERLEE
EVAKVIVSMS VAFAQQTELS RLSRGKENTT SLKQAHILCQ QEEEHIGEVK SSQGQVSLQT
FEEMEMKFKK EYKPLSKELE DGQEVVLSSN GDFDDVLELK DHGLTISEEL FSNDESFIVK
ESIHDEMLVS SMDASRQLML HEEQLEDMRQ ELVRQYEEHQ QATELLRQAH MRQMERQRED
QEQLQEEIKR LNRQLAQRSS IDNENLVSER ERLLLEELEA LKQLSLAGRE KLCCELRNSS
TQTQNGNENQ VEVEEQMFKV KELDRKPEDV PPDILSNERY ALQKANNRLL KILLEVVKTT
AAAEETIGRH VLGILDRSCK GQSCSNLVWR SEAEASVVKS CVQEEHTRVT DESIPSYPGS
DMPRNDSSVW SKVPEEETDL SQRLVRSGFV ETEIDPENEE LMLNISSRLQ AAVEKLLEAI
SETSSQLEHA KVTQTELMRE SFRQKQEATE SLKCQEELRE RLHEESRARE QLAVELSKAE
GVIDGYADEK TVFERQIQEK TDIIDRLEQE LLCAGNRLQE LEAEQQQIQE EKELLSRQKE
AMKAEAGPVE RQLLQETEKL MKEKLEVQCQ AEKVRDDLQK QVKALEIDVE EQVSRFIELE
QEKNAELMDL RQQNQALEKQ LEKMRKFLDE QAIDREHERD VFQQEIQKLE QQLKVVPRFQ
PVSEHQTREV EQLTNNLKEK TDKCSELLLS KEQLQRDVQE RNEEIEKLEF RVRELEQALL
VSADTFQKVE DRRQLEAVEA KAELSLEVQL QAERDAIDRK EKEITNLEEQ LEQFREELEN
KNEEVQQLHM QLEIQKKEST TRLQELQQEN KLFKDEMEKL RHSMKESDDV STQDQHVLFG
KFAQIIQEKD VEIDQLNEQI IQLQQQLKLT TDNKVIEEKN ELIRDLETQI ECLLSDQECV
KKNREEEVEQ LNELIEKLQQ ELANIERKTS VYANSLPEEA DSLKHQLDKV TAEKLALEQQ
VETTNEEMAF TKNVLKETNF KMSQLTQELC SLKEECKIKG KMQNVPEKSA ALALDDLSKD
KPELEVVSTE DGFNPLGYQI DLQSFEESTT DSRSLETKLL QLESSISTKD LELTQCYKQI
KDMQEQGQSE TENLQKKIIN LQKILEEKVA AALVSQAQLE AVQEYVKFYR DKQTVSSERE
RTSIQNLDQI TENRVESDVS KLTLRISELE SQVVAMHSSL ISEKKQVETA EKNALEKERR
LIELQKLLED SKKKQEGKES KTSSQGDFEV LKIPTEVIHS SEERLFDELE AFRAESVATK
KELASHKEKV EKLQEELLIK EINIASLQKD LSQVRDQLTG AEDKLSHFIR KGDKSEVQGN
REICICEPLP IEVGESCTSQ TGGALTVHGS SQTLQVLVRN VGVQIDTQNE CSSEEVTEII
SQFTEKIEQM QELHAAEILD MESRHISETE TLKREHYVAV QLLTEECGTL KAVIQCLRSK
EDVTFCIIYD FILDSAADWG HGIYLTQSQG FDTALEDREE IENSTDLFPK KIKGLLRAVH
TEGMQVLSLT ELPCGDGEDH SVQQASESWL EERRAYLSTI SSLKDLITKM QVQREGEVYD
DSQPSENLSD WRGDLLLALQ HVFLKERNVV LAAFQTELTA LGTRDAVGLL SCLEQRIQEQ
GIQYQAAMEC VQKADRRSLL SEIQALRAQM NGRKMILKRE QEKLLEYNMQ QKQSQILEMQ
MELSNVKEKA TELQEQLSSE KMVVAELKSE LAQTKLELET TLKAQHKHLK ELEAFRLEVK
DKTDEVHLLN DTLASEQKKS RELQWALEKE KARLGHSEER EKDELEDLKF SLEDQKQRNT
QLNLLLEQQK QLLNESQQKV ESQRILYDAK LAEEQGRNLE LQVLLDSEKI RIQELSGVLA
RERELRAQLQ SSDEVGQPRP PLPSEELLKE LQRQLEEKHS RIVELLNETE KYKLDSLQTR
QQMEKDRQVH KKTLQTEQEA NTEGQKKMHE LQSKVEDLQR QLEEKRQQVY KLDLEGKRLQ
GIMQEFQKQE LEREEKRESR RILYQNLNEP TSWSFTNDRT RNWVLQQKIE GDTKESNYPK
LTVMNGEETG YNHELEVVRQ KLERAASSLQ HLSQKASNRL QFETADDETF IWVQENIDGI
ILQLQKFIDQ PGEEPSLVSQ SASCGSLTER LLRQNAELTG HISQLTEEKN GLRNTVMKLE
DRIRCYRQAA GDCSSRFSFG GGANIDAIIA SEKEVWNREK STLQKSLKRA EAEVYKLKAE
LRNDNVLQNL SHDSEHATLK RIYGKYLRAE GFRKALIYQK KYLLLLLGGF QECEDATLAL
LARMGGQPAF TDLEVITNRP RAFTRFRSAV RVCIAISRMK FLVRRWHRVT GSGSININRD
GFGLHSGTEK TDPFYHSSGG LELYGEQRHT TYRSRSDLEY PRSPLPFQNR YPGTPADLNP
SSLACSQLQN YDPDRALTDY ITRLEALQRR LGTVQSGIPF TCLLVAP
//
