ID H0V4W6_CAVPO Unreviewed; 502 AA.
AC H0V4W6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=N-sulfoglucosamine sulfohydrolase {ECO:0000313|Ensembl:ENSCPOP00000004673.2};
GN Name=SGSH {ECO:0000313|Ensembl:ENSCPOP00000004673.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000004673.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000004673.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000004673.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR EMBL; AAKN02047339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013002595.1; XM_013147141.1.
DR AlphaFoldDB; H0V4W6; -.
DR STRING; 10141.ENSCPOP00000004673; -.
DR Ensembl; ENSCPOT00000005253.3; ENSCPOP00000004673.2; ENSCPOG00000005198.4.
DR VEuPathDB; HostDB:ENSCPOG00000005198; -.
DR eggNOG; KOG3867; Eukaryota.
DR GeneTree; ENSGT00390000013080; -.
DR HOGENOM; CLU_006332_7_1_1; -.
DR InParanoid; H0V4W6; -.
DR OMA; MAYPMRM; -.
DR OrthoDB; 2427672at2759; -.
DR TreeFam; TF323156; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000005198; Expressed in ovary and 13 other cell types or tissues.
DR GO; GO:0043202; C:lysosomal lumen; IEA:Ensembl.
DR GO; GO:0016250; F:N-sulfoglucosamine sulfohydrolase activity; IEA:Ensembl.
DR GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:Ensembl.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:Ensembl.
DR GO; GO:0006027; P:glycosaminoglycan catabolic process; IEA:Ensembl.
DR GO; GO:0030200; P:heparan sulfate proteoglycan catabolic process; IEA:Ensembl.
DR GO; GO:0061744; P:motor behavior; IEA:Ensembl.
DR CDD; cd16027; SGSH; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR032506; SGSH_C.
DR InterPro; IPR024607; Sulfatase_CS.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR43108; N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43108:SF6; N-SULPHOGLUCOSAMINE SULPHOHYDROLASE; 1.
DR Pfam; PF16347; SGSH_C; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR PROSITE; PS00523; SULFATASE_1; 1.
DR PROSITE; PS00149; SULFATASE_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..502
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003541534"
FT DOMAIN 23..327
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT DOMAIN 419..472
FT /note="N-sulphoglucosamine sulphohydrolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16347"
SQ SEQUENCE 502 AA; 56637 MW; 2B264923B36C1F9C CRC64;
MSRPGPVCCA LLLLLGLCRA RPRNALLILA DDGGFESGVY NNSAIATPHL DALARRSLVF
RNAFTSVSSC SPSRASLLTG LPQHQNGMYG LHQDVHHFNS FDKVRSLPLL LSQAGVRTGI
IGKKHVGPEA VYPFNFAYTE ENGSVLQVGR NITRIKLLVR KFLQTQDSRP FFLYVAFHDP
HRCGHSQPQY GAFCEKFGNG ESGMGRIPDW TPQTYNPQDV VVPYFVPDTP AARADLAAQY
TTIGRMDQGI GLVLQELRGA GVLNDTLVIF TSDNGIPFPS GRTNLYWPGT AEPLLVSSPK
HPKRWGQVSE AYVSLLDLTP TILDWFSIPY PTYAIFGSKT VQLTGRSLLP ALETEPPWAT
VFGSQSHHEV TMSYPMRSVY HRNFRLVHNL SFRMPFPVDQ DFYISPTFQD LLNRTVAGQP
TGWYKDLHHY YYRERWELYD DHLDPWETQN LAADPHFAEV LAMLKTRLAK WQWETHDPWV
CAPDGVLEEK LSPQCRPLHN EL
//
