GenomeNet

Database: UniProt
Entry: H0V5H5_CAVPO
LinkDB: H0V5H5_CAVPO
Original site: H0V5H5_CAVPO 
ID   H0V5H5_CAVPO            Unreviewed;       817 AA.
AC   H0V5H5; G8Z965;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   28-MAR-2018, entry version 49.
DE   SubName: Full=Two pore channel 1 {ECO:0000313|EMBL:ADK66886.1};
DE   SubName: Full=Two pore segment channel 1 {ECO:0000313|Ensembl:ENSCPOP00000004906};
GN   Name=TPCN1 {ECO:0000313|EMBL:ADK66886.1,
GN   ECO:0000313|Ensembl:ENSCPOP00000004906};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000004906};
RN   [1] {ECO:0000313|EMBL:ADK66886.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Liver {ECO:0000313|EMBL:ADK66886.1};
RA   Ruas M., Mozley E., Parrington J., Galione A.;
RT   "Cloning of guinea pig two pore channels.";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000004906}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000004906};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [3] {ECO:0000313|Ensembl:ENSCPOP00000004906}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000004906};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02056159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GU291347; ADK66886.1; -; mRNA.
DR   RefSeq; NP_001265689.1; NM_001278760.1.
DR   RefSeq; XP_003461405.2; XM_003461357.3.
DR   Ensembl; ENSCPOT00000005508; ENSCPOP00000004906; ENSCPOG00000005450.
DR   GeneID; 100717872; -.
DR   CTD; 53373; -.
DR   eggNOG; ENOG410KCTW; Eukaryota.
DR   eggNOG; ENOG410XZT8; LUCA.
DR   GeneTree; ENSGT00530000063660; -.
DR   InParanoid; H0V5H5; -.
DR   OrthoDB; EOG091G038K; -.
DR   TreeFam; TF328550; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000005450; -.
DR   GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR   Gene3D; 1.20.120.350; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028801; TPC1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF231; PTHR10037:SF231; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    108    130       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    136    154       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    175    193       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    236    255       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    262    281       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    301    324       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    446    466       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    478    496       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    568    587       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    667    692       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      107    331       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      442    691       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      771    791       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   817 AA;  94221 MW;  93023E9B10CB7145 CRC64;
     MAVNLDDDVP LILTMEEGGG APAAPCNSLG PEELPSKNGG SHAIHDSQAP SLVFGGESSP
     SGPAGQDWEM NYQEAAIYLQ EGENNDKFFT HPKDAKALAA YLFAHNHVFY LMELLTALLL
     LLLTLCEAPA VPALRLGIYV HATLELFALM VVVFELCMKL RWLGLHTFIR HKRTMVKTFV
     LVVQFVEAIV VLVRQTSHVR VTRALRCIFL VDCRYCGGVR RNLRQIFQSL PPFMDILLLL
     LFFMIIFAIL GFYLFSSNPS DPYFSTLENS IVSVFVLLTT ANFPDVMMPS YSRNPWSCVF
     FIVYLSIELY FIMNLLLAVV FDTFNDIEKR KFKSLLLHKR TAIQHAFRLL TSQRKPMGIS
     YRQFEGLMRF YKPRMSARER FLTFKALNQS NKPLLSLEDF CDIYEIATLK WKTKRNREHW
     FDELPRTAFL IFKGINMLVK SKAFQYFMYL VVAVNGVWIL VETFMLRGGN FISKPVPWSY
     LIFLTIYGVE LFLKVAGLGP VQYLSSRWNL FDFSVTVFAF LGLLALALNM EPFYFIVVLR
     PLQLLRLFKL KKRYSNVLDT MFELLPRMAS LGLTLLIFYY SFAIVGMEFF CGRLYPNCCN
     TSTVADAYRW LNHTVGDKTV VEEGYYYLNN FDNILNSFVT LFELTVVNNW YIIMEGVTSQ
     TSHWSRLYFM TFYIVTMVVM TIIVAFILEA FVFRMNYSRK SQDSEVDGGI TVEKEISKEE
     LVAVLELYRG ARGASSDVTR LLETLSQMEK YQQNSLVFLG RRSRTKSDLS LKMYQEEIQE
     WYAEHAREQE AQRQLHGGTD PATQQAPYSR QRSQTVT
//
DBGET integrated database retrieval system