ID   H0V5X1_CAVPO            Unreviewed;       673 AA.
AC   H0V5X1;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=FAST kinase domains 2 {ECO:0000313|Ensembl:ENSCPOP00000005070.3};
GN   Name=FASTKD2 {ECO:0000313|Ensembl:ENSCPOP00000005070.3};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000005070.3, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000005070.3}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000005070.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AAKN02019513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_013013176.1; XM_013157722.1.
DR   AlphaFoldDB; H0V5X1; -.
DR   STRING; 10141.ENSCPOP00000005070; -.
DR   Ensembl; ENSCPOT00000005685.3; ENSCPOP00000005070.3; ENSCPOG00000005624.4.
DR   GeneID; 100718328; -.
DR   KEGG; cpoc:100718328; -.
DR   CTD; 22868; -.
DR   VEuPathDB; HostDB:ENSCPOG00000005624; -.
DR   eggNOG; ENOG502QVSD; Eukaryota.
DR   GeneTree; ENSGT01030000234607; -.
DR   HOGENOM; CLU_025270_0_0_1; -.
DR   InParanoid; H0V5X1; -.
DR   OMA; FEIRMDS; -.
DR   OrthoDB; 5257459at2759; -.
DR   TreeFam; TF352875; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000005624; Expressed in liver and 13 other cell types or tissues.
DR   GO; GO:0042645; C:mitochondrial nucleoid; IEA:Ensembl.
DR   GO; GO:0035770; C:ribonucleoprotein granule; IEA:Ensembl.
DR   GO; GO:0019843; F:rRNA binding; IEA:Ensembl.
DR   GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR   GO; GO:1902775; P:mitochondrial large ribosomal subunit assembly; IEA:Ensembl.
DR   GO; GO:0032543; P:mitochondrial translation; IEA:Ensembl.
DR   GO; GO:0070131; P:positive regulation of mitochondrial translation; IEA:Ensembl.
DR   GO; GO:0044528; P:regulation of mitochondrial mRNA stability; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:Ensembl.
DR   InterPro; IPR010622; FAST_Leu-rich.
DR   InterPro; IPR013584; RAP.
DR   PANTHER; PTHR21228:SF1; FAST KINASE DOMAIN-CONTAINING PROTEIN 2, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR21228; FAST LEU-RICH DOMAIN-CONTAINING; 1.
DR   Pfam; PF06743; FAST_1; 1.
DR   Pfam; PF08373; RAP; 1.
DR   SMART; SM00952; RAP; 1.
DR   PROSITE; PS51286; RAP; 1.
PE   4: Predicted;
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT   DOMAIN          598..655
FT                   /note="RAP"
FT                   /evidence="ECO:0000259|PROSITE:PS51286"
SQ   SEQUENCE   673 AA;  77610 MW;  6E1E0EC794D5BDBC CRC64;
     MSNKTGSILW SLRRFSTLVP ARRTLSIYSL GLCRPKLAHS NWNPRNCPIN DFDNRMQPSV
     VRYLFWDALM LKSQNDGFES ENLNTVTVFR VDRLCSRKIS FDSKHSFISA GTCDNELKKV
     NFHHDVSSKD ELSQEMKPTP ISYTKLSEES NSLSDVLDAF SEAPTFPSSK YFLALWTVAK
     RMSEDQKRYE KQLMFKHPAF NQLCEQAIRE ANRMHYNQLL YSLHAIVKLG VFQNTLVVQT
     LLRVIQERIN ECDERDLSIL SALLQAMEPC KNVHALQTGL WLLVDQQVWK IKHIFSLQTV
     MKYIGKDAPV ALKRKLEIKA LMELSRFSHV NSLHMFEVLA SMNHRSVVLL NACSKVAVDN
     IHGCSIKIFI SILQSCKDLR YYNSDLFKGI ADYVATTFDI WKVKHVVFLL ILFEKLSFRP
     LYLMNVFVKK ITEEPELLNQ KNIISILHVY SSLNYIDKEF LDMIARTLTD CLHHVSHENL
     LDALCSFCKM NYFPSTLLDE LLQKDVISEL LTTGDTEKNI YKLHVVDACL QLDCASYPKA
     IGTALPLLPS FPSFPNEKVT EGLNRLLEGS RDFLSKDVQL PHNYYIDFEI RTDANRRVAV
     LCVPKSAYCL DLSHPRGFLA MKIRHLNIMG FHVVLVKRWE MEKLKMEDAI LFLKNKIYSS
     EVVPTKANSQ SPY
//