ID H0V5X2_CAVPO Unreviewed; 483 AA.
AC H0V5X2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=PAT complex subunit CCDC47 {ECO:0000256|ARBA:ARBA00034875};
DE AltName: Full=Coiled-coil domain-containing protein 47 {ECO:0000256|ARBA:ARBA00034902};
GN Name=CCDC47 {ECO:0000313|Ensembl:ENSCPOP00000005072.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000005072.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000005072.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000005072.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Rough endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00034697}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00034697}.
CC -!- SIMILARITY: Belongs to the CCDC47 family.
CC {ECO:0000256|ARBA:ARBA00034746}.
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DR EMBL; AAKN02045207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02045208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003465973.1; XM_003465925.3.
DR AlphaFoldDB; H0V5X2; -.
DR STRING; 10141.ENSCPOP00000005072; -.
DR Ensembl; ENSCPOT00000005687.3; ENSCPOP00000005072.2; ENSCPOG00000005626.4.
DR GeneID; 100716345; -.
DR KEGG; cpoc:100716345; -.
DR CTD; 57003; -.
DR VEuPathDB; HostDB:ENSCPOG00000005626; -.
DR eggNOG; KOG2357; Eukaryota.
DR GeneTree; ENSGT00390000013997; -.
DR HOGENOM; CLU_033196_1_0_1; -.
DR InParanoid; H0V5X2; -.
DR OMA; VYTLWCS; -.
DR OrthoDB; 5252467at2759; -.
DR TreeFam; TF314902; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000005626; Expressed in adrenal gland and 13 other cell types or tissues.
DR GO; GO:0160064; C:multi-pass translocon complex; IEA:Ensembl.
DR GO; GO:0101031; C:protein folding chaperone complex; IEA:Ensembl.
DR GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0044183; F:protein folding chaperone; IEA:Ensembl.
DR GO; GO:0043022; F:ribosome binding; IEA:Ensembl.
DR GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0006983; P:ER overload response; IEA:Ensembl.
DR GO; GO:0160063; P:multi-pass transmembrane protein insertion into ER membrane; IEA:Ensembl.
DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:Ensembl.
DR InterPro; IPR012879; CCDC47.
DR PANTHER; PTHR12883; ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED; 1.
DR PANTHER; PTHR12883:SF0; PAT COMPLEX SUBUNIT CCDC47; 1.
DR Pfam; PF07946; CCDC47; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..483
FT /note="PAT complex subunit CCDC47"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003542495"
FT REGION 42..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..106
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..471
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 483 AA; 55841 MW; 1FF5E63EB5932928 CRC64;
MKTFHAFCIV LLVFGSVSEA KFDDFEDEDD IVEYDDNDFA EFEDVVEDSV TESPPRLITT
EDDEDETTVE LEGQDENQEG DFEDADTQEG DTESEPYDDE EFEGYEDKTD TSSSKNKDPI
TIVDVPAHLQ NSWESYYLEI LMVTGLLAYI MNYIIGKNKN SRLAQAWFNT HRELLESNFT
LVGDDGTNKE ATSTGKLNQE NEHIYNLWCS GRVCCEGMLI QLRFLKRQDL LNVLARMMRP
VSDQVQIKVT MNDEDMDTFV FAVGTRKALV RLQKEMQDLS EFCSDKPKSG AKYGLPDSLA
ILSEMGEVTE GMMDTKMVHF LTHYADKIES VHFSDQFSGP KIMQEEGQPL KLPDTKRTLL
FTFNVPGLGN TYPKDMEALL PLMNMVIYSI DKAKKFRLNR EGKQKADKNR ARVEENFLKL
THVQRQEAAQ SRREEKKRAE KERIMNEEDP EKQRRLEEAA LRREQKKLEK KQMKMKQIKV
KAM
//
