ID H0V5X4_CAVPO Unreviewed; 1088 AA.
AC H0V5X4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=RAN binding protein 17 {ECO:0000313|Ensembl:ENSCPOP00000005074.3};
GN Name=RANBP17 {ECO:0000313|Ensembl:ENSCPOP00000005074.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000005074.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000005074.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000005074.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|ARBA:ARBA00009466}.
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DR EMBL; AAKN02022809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02022810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02022811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02022812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02022813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02022814; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02022815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02022816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02022817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02022818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003473255.1; XM_003473207.3.
DR AlphaFoldDB; H0V5X4; -.
DR Ensembl; ENSCPOT00000005689.3; ENSCPOP00000005074.3; ENSCPOG00000005628.4.
DR VEuPathDB; HostDB:ENSCPOG00000005628; -.
DR eggNOG; KOG1410; Eukaryota.
DR GeneTree; ENSGT00940000153139; -.
DR HOGENOM; CLU_005409_0_0_1; -.
DR TreeFam; TF314248; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000005628; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005049; F:nuclear export signal receptor activity; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR044189; XPO4/7-like.
DR PANTHER; PTHR12596; EXPORTIN 4,7-RELATED; 1.
DR PANTHER; PTHR12596:SF8; RAN-BINDING PROTEIN 17; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 30..95
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
SQ SEQUENCE 1088 AA; 124476 MW; AF65CEB9ADE9C2DC CRC64;
MAQHFQSLAE LELLCTHLYV ETDLSQRIEA EKALLELIDS PECLSKCQLL LEQGTTSYAQ
LLAATCLSKL TSRISPLPIE QRIDIRNYIL NYVASQPKLA PFVIQALVQV IAKITKLGWF
EVQKDQFIFR DIIADVKKFL QGTVEHCVIG VIILSELTQE MNLVDYSRPS AKHRKIATSF
RDISLKDIFV LACSLLKEIL SKPLNLQDQD QQNLVMQVLK LVLNCLSFDF IGSSADESAD
DLCTVQIPTT WRTIFLEPET LDLFFNLYHA LPPLLSQLAL SCLVQFASTR RSLFSSPERS
IYLGNLMKGV KRILENPQGL SDPGNYHEFC RFLARLKSNY QLGELVMVKE YPEVIRLIAN
FTITSLQHWE FAPNSIHYLL TLWQRMVASV PFVKSTEPHL LDTYAPEITK AFITSRLESV
AVVVRDHLDD PLDDTATVFQ QLEQLCTVSR CEYEKTCTLL VQLFDQNAQN YQKLLHSTSR
IAVDLAIQEG RLAWLVYLVG TVVGGRLTYT STDEHDVMDG ELSCRVFQLI SLMDTGLPQC
SNEKIELAIL WFLDQFRKTY VGDQLQRTSK VYARMSEILG ITDDNHVLET FMTKVVTNLK
YWGRCEPVIS RTLQFLNDLS VGYILLKKLV KIDAVKFMLK NHTSEHFPFL GINDSYSLHD
FRCRTTFYTA LTRLLMVDLG EDEDEFENFM LPLTVSFETV LQIFNNSFKQ EDVKRMLIGL
ARDLRGIAFA LNTKTSYTML FDWMYPTYLP VLQRAIEQWY REPACTTPIL KLMAELMQNR
SQRLNFDVSS PNGILLFREA SKMICTYGNQ ILSLGNLSKD QIYPMKLKGI SICYSALKSA
LCGNYVSFGV FKLYGDNHFD NVLQAFVKML LSVSHSDLLQ YRKLSQSYYP LLECLTQDHM
SFIAGLEPPV LLYVLTSMSE GLTSLDTVVS SSCCTSLDYI VTYLFKHIAK EGKKPLRCRE
ATQAGQRLLH FMQQNPDVLQ QMMSVLMNTI VFEDCRNQWS VSRPLLGLIL LNEKCFSELR
ASLINSQPLP KQEVLAQCFR NLMEGVEQNL SIKNRDRFTQ NLSVFRRDVA EALRSDGHPE
LCNLDMMS
//
