ID H0V5X9_CAVPO Unreviewed; 220 AA.
AC H0V5X9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
GN Name=WNT16 {ECO:0000313|Ensembl:ENSCPOP00000005080.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000005080.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000005080.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000005080.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR EMBL; AAKN02017358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0V5X9; -.
DR Ensembl; ENSCPOT00000005696.3; ENSCPOP00000005080.3; ENSCPOG00000005635.4.
DR VEuPathDB; HostDB:ENSCPOG00000005635; -.
DR GeneTree; ENSGT00940000157480; -.
DR HOGENOM; CLU_033039_1_0_1; -.
DR TreeFam; TF105310; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000005635; Expressed in uterine cervix and 3 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR013304; Wnt16.
DR PANTHER; PTHR12027:SF70; PROTEIN WNT-16; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01895; WNT16PROTEIN.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..220
FT /note="Protein Wnt"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013311317"
SQ SEQUENCE 220 AA; 24152 MW; E1F781604C178E4C CRC64;
MDRAALLALP RLCALWAALL ALFPCGAQGN WMWLGIASFG VPEKLGCANL PLNSRQKELC
KRKPYLLPSI REGARLGIQE CRSQFKHERW NCEVAAGPVL GTGPLFGYEL SSGTKETAFI
YAVMAAGLVH SVTRSCSAGN MTECSCDTTL QNGGSASEGW HWGGCSDDVQ YGMWFSRKFL
DLPIRNTTEE DRKVLLAMNL HNNEAGRQLT KLPLQLKTSV
//
