ID H0V600_CAVPO Unreviewed; 498 AA.
AC H0V600;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Fascin {ECO:0000256|PIRNR:PIRNR005682};
GN Name=FSCN3 {ECO:0000313|Ensembl:ENSCPOP00000005104.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000005104.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000005104.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000005104.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR005682}.
CC -!- SIMILARITY: Belongs to the fascin family.
CC {ECO:0000256|ARBA:ARBA00007415, ECO:0000256|PIRNR:PIRNR005682}.
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DR EMBL; AAKN02017519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003475211.1; XM_003475163.1.
DR AlphaFoldDB; H0V600; -.
DR STRING; 10141.ENSCPOP00000005104; -.
DR Ensembl; ENSCPOT00000005722.3; ENSCPOP00000005104.2; ENSCPOG00000005661.4.
DR GeneID; 100726411; -.
DR KEGG; cpoc:100726411; -.
DR CTD; 29999; -.
DR VEuPathDB; HostDB:ENSCPOG00000005661; -.
DR eggNOG; ENOG502QSD9; Eukaryota.
DR GeneTree; ENSGT00950000183157; -.
DR HOGENOM; CLU_030960_2_0_1; -.
DR InParanoid; H0V600; -.
DR OMA; MADGHPM; -.
DR OrthoDB; 5351436at2759; -.
DR TreeFam; TF323992; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000005661; Expressed in testis.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR CDD; cd00257; Fascin; 3.
DR Gene3D; 2.80.10.50; -; 4.
DR InterPro; IPR008999; Actin-crosslinking.
DR InterPro; IPR010431; Fascin.
DR InterPro; IPR022768; Fascin-domain.
DR InterPro; IPR024703; Fascin_metazoans.
DR PANTHER; PTHR10551; FASCIN; 1.
DR PANTHER; PTHR10551:SF1; FASCIN-3; 1.
DR Pfam; PF06268; Fascin; 2.
DR PIRSF; PIRSF005682; Fascin; 1.
DR SUPFAM; SSF50405; Actin-crosslinking proteins; 4.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR005682};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005682};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR005682};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 26..126
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 273..378
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
SQ SEQUENCE 498 AA; 56417 MW; 5808DF6B97F9B08E CRC64;
MDEVEWMPRH PKPEDLRIGL ISWAGTYLTF EAYRNAVRAN AKSLGRRQIW DLLVSNEQET
QAVVRLKSLK GLYLLCEADG SVCHGHPRTS HHGCFLLRFH RNGKWTLQCI ISGRYLESDG
EDVFCNSRVL SAYHMWTPRP ALHVHVTLYS PIYHTYARAD HSVGRIWMDA AVPCIEECGF
LLHFQDGCYH LETSTHHFLS HVDRLVSQLS PQTAFHMQVR PRGLVALCDG EGGTLYPQGS
HLLLGVGSSP VRGAEWFVLQ HFPTWVSLRS KARKFLSVIY GAEVCATSER LTSMSLFQFE
CDNESLTLQL RSSNGCYLAQ RPHKSVIADG HPMESDTFFR MHWNCGKIIL QSSNGRFLSI
APNGLLIANA TIPGPDEELA IRFANRPFLI LRGRYGYVGS TSERDFIQCN MDQPDCIQLL
PCRQGIYHFQ AKGGSFWSIT SFGTFRPWGK FALNFCVELQ GSNLLTVLAP NGFYMRADRS
GTLLADSEDI TRECIWEF
//
