ID H0V6W3_CAVPO Unreviewed; 568 AA.
AC H0V6W3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Apoptosis antagonizing transcription factor {ECO:0000313|Ensembl:ENSCPOP00000005450.3};
GN Name=AATF {ECO:0000313|Ensembl:ENSCPOP00000005450.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000005450.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000005450.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000005450.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AATF family.
CC {ECO:0000256|ARBA:ARBA00008966}.
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DR EMBL; AAKN02033089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02033090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013007790.1; XM_013152336.1.
DR AlphaFoldDB; H0V6W3; -.
DR STRING; 10141.ENSCPOP00000005450; -.
DR Ensembl; ENSCPOT00000006101.3; ENSCPOP00000005450.3; ENSCPOG00000006037.4.
DR GeneID; 100732839; -.
DR KEGG; cpoc:100732839; -.
DR CTD; 26574; -.
DR VEuPathDB; HostDB:ENSCPOG00000006037; -.
DR eggNOG; KOG2773; Eukaryota.
DR GeneTree; ENSGT00390000000288; -.
DR HOGENOM; CLU_018299_1_2_1; -.
DR InParanoid; H0V6W3; -.
DR OMA; RRIRYHV; -.
DR OrthoDB; 26012at2759; -.
DR TreeFam; TF324341; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000006037; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032040; C:small-subunit processome; IEA:Ensembl.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0043522; F:leucine zipper domain binding; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0040016; P:embryonic cleavage; IEA:Ensembl.
DR GO; GO:0042985; P:negative regulation of amyloid precursor protein biosynthetic process; IEA:Ensembl.
DR GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0032929; P:negative regulation of superoxide anion generation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; IEA:Ensembl.
DR InterPro; IPR025160; AATF.
DR InterPro; IPR039223; AATF/Bfr2.
DR InterPro; IPR012617; AATF_C.
DR PANTHER; PTHR15565; AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR15565:SF0; PROTEIN AATF; 1.
DR Pfam; PF13339; AATF-Che1; 1.
DR Pfam; PF08164; TRAUB; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 230..381
FT /note="AATF leucine zipper-containing"
FT /evidence="ECO:0000259|Pfam:PF13339"
FT DOMAIN 472..556
FT /note="Apoptosis-antagonizing transcription factor C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08164"
FT REGION 72..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..203
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 63877 MW; 7B9D4D7DBD9DAB29 CRC64;
MAGPQPLALQ LEQLLNPRPR EEDPEADTEE ATAARVIDRF DEGEDGEGDF LAVGSIRKRA
SAFVLDTDKR YSGKATSRKA WKEDCWEQTV PGVSDQEISD KEGSGDGVSE ALSLEESDAG
DLSAAEEQDA DDSEESSPAW KKGRSHSAKA PGFSFQSISD FEKFTEGMDD LGSSEEEEEE
EEESGMEEGD GDGEEDSDEE SEGDGAAARD RQSEDDGVVL TFSGAKVSEE VEKGRAVKNQ
IALWDQLLEG RIKLQKALLT TNQLPQPDVF PVFKDKGGPE FASALKNSHK ALKALLRSLV
DLQEELLFQY PDTRYLVDGT KPKEESEEIS SEDDETLDRK QKRKAVPKRK LEMDAYPGFM
AKRFADFTVY RNRTLQKWHD RTKLASGKLG KSFSAFERSI LTQIDHILMD KERLLRRTQT
KRSVYRVLGK PEPEAPPVPK SLPGEPEILP QISANAHLKD LDEEIFDDDD FYHQLLRELI
ERKTSSLDPN DQLAMGRQWL AIQKLRSKIH KKVDRKASKG RKLRFHVLSK LLSFMAPIDH
TTMNDDARTE LYRSLFGQLN PPATGHRD
//
