GenomeNet

Database: UniProt
Entry: H0V7J1_CAVPO
LinkDB: H0V7J1_CAVPO
Original site: H0V7J1_CAVPO 
ID   H0V7J1_CAVPO            Unreviewed;      1810 AA.
AC   H0V7J1;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   05-JUN-2019, entry version 59.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000005701};
GN   Name=LAMA4 {ECO:0000313|Ensembl:ENSCPOP00000005701};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000005701};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000005701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000005701};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000005701}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000005701};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; AAKN02043610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02043611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02043612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_013004442.1; XM_013148988.1.
DR   STRING; 10141.ENSCPOP00000005701; -.
DR   Ensembl; ENSCPOT00000006390; ENSCPOP00000005701; ENSCPOG00000006325.
DR   GeneID; 100716529; -.
DR   CTD; 3910; -.
DR   eggNOG; ENOG410KCXD; Eukaryota.
DR   eggNOG; ENOG410Z3D5; LUCA.
DR   GeneTree; ENSGT00940000159970; -.
DR   InParanoid; H0V7J1; -.
DR   OrthoDB; 2342at2759; -.
DR   TreeFam; TF335359; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000006325; Expressed in 3 organ(s), highest expression level in brain.
DR   GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR   GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR   GO; GO:0043083; C:synaptic cleft; IEA:Ensembl.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
DR   GO; GO:0050873; P:brown fat cell differentiation; IEA:Ensembl.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IEA:Ensembl.
DR   GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR   GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR   GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR009254; Laminin_aI.
DR   InterPro; IPR010307; Laminin_dom_II.
DR   InterPro; IPR002049; Laminin_EGF.
DR   InterPro; IPR001791; Laminin_G.
DR   Pfam; PF00053; Laminin_EGF; 3.
DR   Pfam; PF02210; Laminin_G_2; 5.
DR   Pfam; PF06008; Laminin_I; 1.
DR   Pfam; PF06009; Laminin_II; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00180; EGF_Lam; 3.
DR   SMART; SM00282; LamG; 5.
DR   SUPFAM; SSF49899; SSF49899; 5.
DR   PROSITE; PS01248; EGF_LAM_1; 1.
DR   PROSITE; PS50027; EGF_LAM_2; 3.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00814887};
KW   Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00580772};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Repeat {ECO:0000256|SAAS:SAAS00814929};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26   1810       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5011791905.
FT   DOMAIN       77    126       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      127    181       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      182    235       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      820   1022       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     1034   1214       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     1221   1389       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     1456   1627       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     1634   1807       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   REGION     1398   1426       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H0V7J1}.
FT   COILED      326    346       {ECO:0000256|SAM:Coils}.
FT   COILED      368    388       {ECO:0000256|SAM:Coils}.
FT   COILED      465    492       {ECO:0000256|SAM:Coils}.
FT   COILED      574    601       {ECO:0000256|SAM:Coils}.
FT   COILED      656    676       {ECO:0000256|SAM:Coils}.
FT   COILED      692    712       {ECO:0000256|SAM:Coils}.
FT   COILED      772    792       {ECO:0000256|SAM:Coils}.
FT   DISULFID     96    105       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    152    161       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    207    216       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    219    233       {ECO:0000256|PROSITE-ProRule:PRU00460}.
SQ   SEQUENCE   1810 AA;  200820 MW;  23EEF57A6A8D6502 CRC64;
     MALHPAWRGV LLPLWLLCSA ACCSAASGDG SAFPFDIEGS SAVGRPDPPE TSEPRVTVPE
     KCAPGFFRAF SGECLPCDCH GNSNECSDGS GFCLNCQRNT TGERCEKCLA GYIGDSIREA
     PHACQPCPCP LPHLANFAES CYRKNGAVRC ICKENYAGPN CERCAPGYYG NPLLIGSTCR
     KCDCSGNSDP NLIFEDCDEV TGQCRNCLRN TTGFKCERCA PGYYGDARIA KNCAVCNCGG
     GPCDSVTGEC LEGFELSTGC DKCIWDLTDD LRLAALSIEE SKSGLLSVSS GAAAQRHVSE
     MNSTIHLLKM KLSERENQYI LRKIQVSNAE NTMKSLLSDL DELAVKESQA ARKGQLVHKE
     SMDTTDHATH LAEQAHNMRD KIQEINDKML YYGEEQELDP EEITEKLVLA QKMLEEIRRR
     PPFLTQRELV DAEADEAHEL LSQAEIWQRL HNDTRSLFPV VLEQLDDYNA KLSDLQESLD
     QALDHIRDAE DMNRATAARQ RDHEKQHEKI REQMEVVNTS LSTSAVSLAM PRLILVELDD
     IIKNASGIYA EIDGAKTELQ GKLSNLSNLN PDLVQEAIDH ARNLQQEADE LSRNLHNSDM
     NGLVQKALDA SNVYENIVNY VGEANETAEL ALNITDRIYD AVSGIDTQII YHKDESDHLL
     NQARELEARA DSSSEEAVAD TSRRVSGALT RKSALKHRLD DAIKRLQAAE RGDVRQRLGQ
     SKMIVEQANK TTVEVQKVTA PMANNLTNWS QNLQNFDSSV YNTAVDSARD AVRNLTEVVP
     QLLDQLRTVE QKRPASNVSA SIQRIRELIA QTRSVASKIQ VSMMFDGQSA VDVHPKTSMD
     DLKAFTSLSL YMKPPAKQSE LGGTADQFIL YLGSKNAKKE YMGLAIKNDN LVYVYNLGTK
     DVEIPLDSKP VSSWPAYFSI VKIERVGKHG KVFLTVPSLS STAEEKFIKK GEFAGDDSLL
     DLDPKDTVFY VGGVPSNFKL PASLNLPGYV GCLELATLNS DVISLYNFKH IYNMDPLKSV
     PCARDKLAFT QSRAASYFFD GSSYAVVRDI TRRGKFGQVT RFDIEVRTPA DNGLVLLMVN
     GSTFFSLEMR SGYLHVFYDF GFSNGPVHLE DTLKKAQIND AKYHEISIIY HNDKKMILVV
     DRRHVKSMDN EKMKIPFTDI YIGGAPPEIL QSRALRGHLP LDINFRGCMK GFQFQKKDFN
     LLEQKETLGV GYGCPEDSLV SRRAYFNGQS FIASTQKISF FDGFEGGFNF RTLQPNGLLF
     YYASGADVFS ISLDNGTVTL NVKGTKVQSA EKQYNDGLAH FVSTSVSPTR YELVVDKSRH
     GNKNPTKGKA EQNQAGEKKF YFGGSPISPQ YANFTGCISN AYFTRLDKDV EVEDFQRYSE
     KVHTSLYECP IESSPLFLHH KKGKNSSRPK PNQNRKGGKS KDAPSWDPVG LKFLEHSAPR
     DAHCHLSNSP RAIEHAYQYG GTANSRQEFE HLTGDFGEKS QFSILLKTRS SHGMIFYVSD
     QEENDFMTLF LAHGRLVFMF NVGHKKLKIR SQERYNDGLW HDVIFVREKS SGRLIIDGLR
     VLEESLPPTE TAWKIKGPIY LGGVAPGRAV KNVQINSVYS FSGCLRNLQL NGASITSASQ
     TFSVTPCFEG PMETGTYFST EGGYVVLDES FNIGLKFEIA FEVRPRSSSG TLVHGHSVNG
     EYLNVHMNNG QVIVKVNNGI RDFSTSVTPK QSLCDGRWHR ITVIRDSNVV QLDVDSEVNH
     VVGPLNPKPV DHREPVFVGG VPESLLTPRL APTKPFTGCI RHFVIDGRPV SFNKAALVSG
     AVSINSCPAA
//
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