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Database: UniProt
Entry: H0V8L8_CAVPO
LinkDB: H0V8L8_CAVPO
Original site: H0V8L8_CAVPO 
ID   H0V8L8_CAVPO            Unreviewed;      1007 AA.
AC   H0V8L8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   24-JAN-2024, entry version 71.
DE   SubName: Full=Integrin subunit alpha 2b {ECO:0000313|Ensembl:ENSCPOP00000006129.3};
GN   Name=ITGA2B {ECO:0000313|Ensembl:ENSCPOP00000006129.3};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000006129.3, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000006129.3}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000006129.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC       ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC       {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR   EMBL; AAKN02045623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02045624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0V8L8; -.
DR   STRING; 10141.ENSCPOP00000006129; -.
DR   Ensembl; ENSCPOT00000006870.3; ENSCPOP00000006129.3; ENSCPOG00000006801.4.
DR   VEuPathDB; HostDB:ENSCPOG00000006801; -.
DR   eggNOG; KOG3637; Eukaryota.
DR   GeneTree; ENSGT00940000160724; -.
DR   HOGENOM; CLU_004111_4_1_1; -.
DR   InParanoid; H0V8L8; -.
DR   OMA; LQMDTAN; -.
DR   TreeFam; TF105391; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000006801; Expressed in liver and 13 other cell types or tissues.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0050840; F:extracellular matrix binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR   Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR   Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR   Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR   Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR018184; Integrin_alpha_C_CS.
DR   InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR   InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR   InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR   PANTHER; PTHR23220:SF73; INTEGRIN ALPHA-IIB; 1.
DR   Pfam; PF01839; FG-GAP; 2.
DR   Pfam; PF08441; Integrin_A_Ig_1; 1.
DR   Pfam; PF20805; Integrin_A_Ig_2; 1.
DR   Pfam; PF20806; Integrin_A_Ig_3; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   SMART; SM00191; Int_alpha; 5.
DR   SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR   SUPFAM; SSF69179; Integrin domains; 3.
DR   PROSITE; PS51470; FG_GAP; 4.
DR   PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003762};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003762};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU003762}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   CHAIN           25..1007
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT                   /id="PRO_5011809583"
FT   TRANSMEM        967..988
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   REPEAT          28..89
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          299..364
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          366..425
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          428..489
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   DOMAIN          474..625
FT                   /note="Integrin alpha first immunoglubulin-like"
FT                   /evidence="ECO:0000259|Pfam:PF08441"
FT   DOMAIN          657..755
FT                   /note="Integrin alpha second immunoglobulin-like"
FT                   /evidence="ECO:0000259|Pfam:PF20805"
FT   DOMAIN          761..955
FT                   /note="Integrin alpha third immunoglobulin-like"
FT                   /evidence="ECO:0000259|Pfam:PF20806"
SQ   SEQUENCE   1007 AA;  110089 MW;  001598A6DBC89CFF CRC64;
     MARVSCLLHA LWLLGPAATP VAWALNLNAA QITFYSGPNN SHFGFSVDFH KDSLGSVAVV
     VGAPRARARS QEETGAVFLC PWSAAGGPCS QLFFDLQDET RNASSQTFQV FKARQGLGAS
     VTSWNDTVVA CAPWQHWNVL ERAEEAEKTP VGSCYLAQLR SGSRKEYSPC RANTMSRVYE
     DRLFSRDRRY CEAGFSSVIT QAGELVLGAP GGYFFIGLLA RARIAHIVSS YQPATLLWTV
     PNQHFTFDSS DSKFYDSYRG YAVAVGEFNG DLRTPEYVVG APTWSWTLGA VEILDSHDQT
     LLRLHGEQMA SYFGHTVAVT DVNGDGRHDL LVGAPLFMDS WADRKLAEVG RVYLFLQPPD
     PHLLATPSLL LTGTQLYGRF GSAIAPLGDL NRDGFNDIAV AAPYGGPGGR GQVLVYLGQS
     EGLNAHPSQV LDSPFHTGSG FGFSLRGATD IDDNGYPDLV VGAYGASKVV VYRAQPVVMA
     TIQLLVKDAL NPMEKRCVLP GTRTLVSCFN IKMCVEATGH NIPQKLRLSA ELQLDRQKPR
     QGRRTLLLES QQADTTLSLD LGSRHGPVCH TATAFLRDEA DFRDKLSPIV LSLDVSLPPS
     ESTSAPGLVL HGNTHIQEQT RIILDCGEDD LCVPQLLLNA TVCWSCMWPR PTRARGPYEA
     ELGVLLPSGA HYMRALSDVR GFERLICNQK KENDSRVVLC ELGNPMGKDA QIGITMWVSV
     EDLEQASQAV SFRLQVRSKN SQNPNSQAVL LQVPVQAEAR VELRGNSFPA SLVVSAEGDK
     EQGILDTSGP RVEHTYELHN RGPGTARDLR LGVHLPGQSQ ASDLLYILDV QAHGGLQCSL
     EPSPNPSELD WRPTSASVAL HRQRERRQAG PAEPVLVSCD SAPCTVVQCE LQEMVRGQRA
     MVTMLALLRL PSLRQQGPLV QTVLQSRAWF NVSSLPYAVP ALSLPSGEAV VQTLLLRALE
     ERAVPTWWVL VGALGGLLLL TLLVLAMWKV GFFKRTRPRL DEDEEEE
//
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