ID H0V8L8_CAVPO Unreviewed; 1007 AA.
AC H0V8L8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 24-JAN-2024, entry version 71.
DE SubName: Full=Integrin subunit alpha 2b {ECO:0000313|Ensembl:ENSCPOP00000006129.3};
GN Name=ITGA2B {ECO:0000313|Ensembl:ENSCPOP00000006129.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000006129.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000006129.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000006129.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; AAKN02045623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02045624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0V8L8; -.
DR STRING; 10141.ENSCPOP00000006129; -.
DR Ensembl; ENSCPOT00000006870.3; ENSCPOP00000006129.3; ENSCPOG00000006801.4.
DR VEuPathDB; HostDB:ENSCPOG00000006801; -.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000160724; -.
DR HOGENOM; CLU_004111_4_1_1; -.
DR InParanoid; H0V8L8; -.
DR OMA; LQMDTAN; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000006801; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0050840; F:extracellular matrix binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF73; INTEGRIN ALPHA-IIB; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 25..1007
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5011809583"
FT TRANSMEM 967..988
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 28..89
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 299..364
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 366..425
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 428..489
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 474..625
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 657..755
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 761..955
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1007 AA; 110089 MW; 001598A6DBC89CFF CRC64;
MARVSCLLHA LWLLGPAATP VAWALNLNAA QITFYSGPNN SHFGFSVDFH KDSLGSVAVV
VGAPRARARS QEETGAVFLC PWSAAGGPCS QLFFDLQDET RNASSQTFQV FKARQGLGAS
VTSWNDTVVA CAPWQHWNVL ERAEEAEKTP VGSCYLAQLR SGSRKEYSPC RANTMSRVYE
DRLFSRDRRY CEAGFSSVIT QAGELVLGAP GGYFFIGLLA RARIAHIVSS YQPATLLWTV
PNQHFTFDSS DSKFYDSYRG YAVAVGEFNG DLRTPEYVVG APTWSWTLGA VEILDSHDQT
LLRLHGEQMA SYFGHTVAVT DVNGDGRHDL LVGAPLFMDS WADRKLAEVG RVYLFLQPPD
PHLLATPSLL LTGTQLYGRF GSAIAPLGDL NRDGFNDIAV AAPYGGPGGR GQVLVYLGQS
EGLNAHPSQV LDSPFHTGSG FGFSLRGATD IDDNGYPDLV VGAYGASKVV VYRAQPVVMA
TIQLLVKDAL NPMEKRCVLP GTRTLVSCFN IKMCVEATGH NIPQKLRLSA ELQLDRQKPR
QGRRTLLLES QQADTTLSLD LGSRHGPVCH TATAFLRDEA DFRDKLSPIV LSLDVSLPPS
ESTSAPGLVL HGNTHIQEQT RIILDCGEDD LCVPQLLLNA TVCWSCMWPR PTRARGPYEA
ELGVLLPSGA HYMRALSDVR GFERLICNQK KENDSRVVLC ELGNPMGKDA QIGITMWVSV
EDLEQASQAV SFRLQVRSKN SQNPNSQAVL LQVPVQAEAR VELRGNSFPA SLVVSAEGDK
EQGILDTSGP RVEHTYELHN RGPGTARDLR LGVHLPGQSQ ASDLLYILDV QAHGGLQCSL
EPSPNPSELD WRPTSASVAL HRQRERRQAG PAEPVLVSCD SAPCTVVQCE LQEMVRGQRA
MVTMLALLRL PSLRQQGPLV QTVLQSRAWF NVSSLPYAVP ALSLPSGEAV VQTLLLRALE
ERAVPTWWVL VGALGGLLLL TLLVLAMWKV GFFKRTRPRL DEDEEEE
//