ID H0V949_CAVPO Unreviewed; 623 AA.
AC H0V949;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=HBS1-like protein {ECO:0000256|ARBA:ARBA00015186};
GN Name=HBS1L {ECO:0000313|Ensembl:ENSCPOP00000006327.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000006327.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000006327.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000006327.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC subfamily. {ECO:0000256|ARBA:ARBA00007249}.
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DR EMBL; AAKN02038382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02038383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02038384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02038385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02038386; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0V949; -.
DR STRING; 10141.ENSCPOP00000006327; -.
DR Ensembl; ENSCPOT00000007084.3; ENSCPOP00000006327.3; ENSCPOG00000007015.4.
DR VEuPathDB; HostDB:ENSCPOG00000007015; -.
DR GeneTree; ENSGT00940000156274; -.
DR HOGENOM; CLU_007265_3_6_1; -.
DR InParanoid; H0V949; -.
DR OMA; CFETEHR; -.
DR TreeFam; TF105833; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000007015; Expressed in adrenal gland and 12 other cell types or tissues.
DR GO; GO:0022626; C:cytosolic ribosome; IEA:Ensembl.
DR GO; GO:1990533; C:Dom34-Hbs1 complex; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0070966; P:nuclear-transcribed mRNA catabolic process, no-go decay; IEA:Ensembl.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:Ensembl.
DR CDD; cd16267; HBS1-like_II; 1.
DR CDD; cd04093; HBS1_C_III; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015033; HBS1-like_N.
DR InterPro; IPR037189; HBS1-like_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR PANTHER; PTHR23115:SF188; HBS1-LIKE PROTEIN; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR Pfam; PF08938; HBS1_N; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF109732; HBS1-like domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 248..419
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 123..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 623 AA; 68675 MW; 8EB0479CEC558C8A CRC64;
MARHRNVRGY NYDEDFEDDD FYGQSVEDDY CISPSTAAQF IYSQRDKPSV CYDDLKDSAN
SVSDQQLSGL DQARLYSCLD HMREVLGDAV PDEILIEAVM KNKFDVQKAL SFVLERDNGQ
NLKDKSGRVM STGKIPKGKS VESQSSRSES EIVPKVAKMT VSGKKQTMGF EVPGVAAEEN
GHVIQTPLKG PVDEDTAIAS SDILETVTSS ALPSPLQSDR RADSGRRYVG KQLHQFVPIG
MVLAPKLSLL SNHLMFRLRG VTMDVGMTKF ETTTKVITLM DAPGHKDFIP NMITGAAQAD
VAVLVVDASR GEFEAGFETG GQTREHGLLV RSLGVTQLAV AVNKMDQVNW QQERFQEITG
KLGHFLKQAG FKESDVAFIP TSGLSGENLI TRSQLNELTK WYKGLCLLEQ IDSFKPPQRS
VDKPFRLCVS DVFKDQGSGF CVTGKIEAGY IQIGDRLLAM PPNETCTARG ITLHDEPVDW
AAAGDHVSLN LVGMDIIKIN VGCIFCGPKE PIKACTRFRA RILIFNIEIP ITKGFPVLLH
YQTVSEPAVI KRLISVLSKS SGEVTKKKPK LLTKGQNALV ELQTQRPVAL ELYKDFKELG
RFMLRYSGST IAAGVVTEVF CND
//
