ID H0V986_CAVPO Unreviewed; 1477 AA.
AC H0V986;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Family with sequence similarity 135 member A {ECO:0000313|Ensembl:ENSCPOP00000006367.3};
GN Name=FAM135A {ECO:0000313|Ensembl:ENSCPOP00000006367.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000006367.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000006367.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000006367.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FAM135 family.
CC {ECO:0000256|ARBA:ARBA00007949}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02008019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02008020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02008021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000006367; -.
DR Ensembl; ENSCPOT00000007127.3; ENSCPOP00000006367.3; ENSCPOG00000007057.4.
DR VEuPathDB; HostDB:ENSCPOG00000007057; -.
DR eggNOG; KOG2205; Eukaryota.
DR GeneTree; ENSGT00940000157565; -.
DR HOGENOM; CLU_003176_0_0_1; -.
DR InParanoid; H0V986; -.
DR OMA; TIHACLV; -.
DR TreeFam; TF314837; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000007057; Expressed in testis and 12 other cell types or tissues.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR022122; DUF3657.
DR InterPro; IPR007751; DUF676_lipase-like.
DR InterPro; IPR044294; Lipase-like.
DR PANTHER; PTHR12482:SF40; PROTEIN FAM135A; 1.
DR PANTHER; PTHR12482; UNCHARACTERIZED; 1.
DR Pfam; PF12394; DUF3657; 1.
DR Pfam; PF05057; DUF676; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 1207..1401
FT /note="DUF676"
FT /evidence="ECO:0000259|Pfam:PF05057"
FT REGION 415..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 963..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1477 AA; 165089 MW; 910B7ECF0B5B5AC2 CRC64;
MTEVQAMVEF SVELNKFYNV DLFQRGCLPV LSVLGITLAF PASVHDSFIC SKTFQILYKN
EEVVLNDVMI FKVKMLLDEK KIEETLEEMS FLLSLDLHFT DGDYSTDDLN ALQLISSRTL
KLHFSLYRGL HHHVNVMFDY FHLSVVSVTV HASLVALHQP LISFPRPVKT TWLNRNAPAQ
NKDSVIPTLE SVVFGINYTK QLSPDGCSFI IADSFLHHAY RFHYSLCAIL LLAFKGLHSY
FITVTEEIPS CQKLELGMSK VEATFFLSFQ KIENPDELAE LINMNLAQLC SLLMALWGQF
LEVITLHEEL RILLAQEHHT LRVRRFSEAF FCFEHPREAA IAYQELHAQS HLQMCTAIKN
TSFCSSLPPL PIECSELDGD LNSLPIIFED RYLDSVIEDL DAPWMGIQSL QKSESSRMDK
YENEESSVAG LSSPELKVKP AGASSIWYTE GEKQLTKPPK GKNEESNKSK VKVAKLMKTM
KPENPKKLIK QNSKDSVILV GYKCLKSTAS NDLTKCFEGN PLHSQKDGLD PTMCGYNFDP
KSCIRQTSQN EASYLPTNTE RTEQKSPDIE NIQPNQFNPL NSGSLNLCAN LSISGKLDIS
QDDSENTHLD HNMACRSSSD DCHEHQTAPS SGVKTIEINP CNNSPLSGEI ITVQRGPWAE
LRQDAMFVDN LLPSFESLDS NGKFKSVETT VEKETLQEAK CRFVGESLAK LRSNPSAPST
KEYHVVVSGD TIKLPDTNST YASSRFSDSG VESEPSSFAT HPNLDIVLEA TQEQGPFNNE
RLLPQLLMKP DCNVKFSLGS HCTESTSALS EIQSSLTSIN SLPSDDELSP DENSKKCVVP
ECHLSDSKTV LNLGTVDLPK CDETKKSSII LQQQSVVFSE HLDSETLAIH SLNSSTKDPL
QLVFLDKDTS SDVESSCSSK PKFDTTYKGP QSPDKSNNSA RTAMLNPKLI CLGTSCVVSG
SVSTNAEGSK DGTVEGKNSD PLHLRDDPFS PSTDLVKQGL VENYFGSQNI TDISGTCNVS
CDNSVISQKE TCQKGISNLQ QEQGNEDEED EQDQRMVQNG YYEETDCPAL DETINAPYTS
RDPLAEERLI KSEKLKSDYL RDGMNMPIVC TSGCLSFPSA PRESPCSIKY SSKSKFDAIT
KQPSSISHNF TSSISWYENS PKPQIQAFLQ AKEELKQLKL PGFMYSDVPL LASSVPYFSM
EEEDVSEDGV HLIVCVHGLD GNSADLRLVK TYIELGLPGG RIDFLMSERN QNDTFADFDS
MTDRLLDEII QYIQIYSLTV SKISFIGHSL GNLIIRSVLT RPRFKYYLSR LHTFLSLSGP
HLGTLYNSST LVNTGLWFMQ KWKKSGSLLQ LTCRDHSDPR QTFLYKLSNK AGLHYFKNVV
LVGSLQDRYV PYHSARIEMC KTALKDKQSG QIYSEMIHNL LRPVLQSQDC NLVRYNVINA
LPNTADSLIG RAAHIAVLDS EIFLEKFFLV AALKYFQ
//
