ID H0V991_CAVPO Unreviewed; 1051 AA.
AC H0V991;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Immunoglobulin mu DNA binding protein 2 {ECO:0000313|Ensembl:ENSCPOP00000006373.3};
GN Name=IGHMBP2 {ECO:0000313|Ensembl:ENSCPOP00000006373.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000006373.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000006373.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000006373.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
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DR EMBL; AAKN02038579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003468365.2; XM_003468317.3.
DR AlphaFoldDB; H0V991; -.
DR STRING; 10141.ENSCPOP00000006373; -.
DR Ensembl; ENSCPOT00000007133.3; ENSCPOP00000006373.3; ENSCPOG00000007063.4.
DR GeneID; 100728700; -.
DR KEGG; cpoc:100728700; -.
DR CTD; 3508; -.
DR VEuPathDB; HostDB:ENSCPOG00000007063; -.
DR eggNOG; KOG1803; Eukaryota.
DR GeneTree; ENSGT00930000151035; -.
DR HOGENOM; CLU_001666_5_0_1; -.
DR InParanoid; H0V991; -.
DR OMA; TIIHGPP; -.
DR OrthoDB; 170190at2759; -.
DR TreeFam; TF105388; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000007063; Expressed in cerebellum and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:Ensembl.
DR GO; GO:0032574; F:5'-3' RNA helicase activity; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0036121; F:double-stranded DNA helicase activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0043022; F:ribosome binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0000049; F:tRNA binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0010501; P:RNA secondary structure unwinding; IEA:Ensembl.
DR CDD; cd18044; DEXXQc_SMUBP2; 1.
DR CDD; cd02641; R3H_Smubp-2_like; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 2.40.30.270; -; 1.
DR Gene3D; 4.10.1110.10; AN1-like Zinc finger; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035896; AN1-like_Znf.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR034072; R3H_Smubp-2.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR004483; SMUBP-2/Hcs1-like.
DR InterPro; IPR048761; SMUBP-2_HCS1_1B.
DR InterPro; IPR000058; Znf_AN1.
DR NCBIfam; TIGR00376; IGHMBP2 family helicase; 1.
DR PANTHER; PTHR43788:SF19; DNA-BINDING PROTEIN SMUBP-2; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF21138; SMUBP-2_HCS1_1B; 1.
DR Pfam; PF01428; zf-AN1; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00393; R3H; 1.
DR SMART; SM00154; ZnF_AN1; 1.
DR SUPFAM; SSF118310; AN1-like Zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS51039; ZF_AN1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00449}.
FT DOMAIN 788..851
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 949..998
FT /note="AN1-type"
FT /evidence="ECO:0000259|PROSITE:PS51039"
FT REGION 23..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 850..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 896..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1011..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 372..399
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 917..938
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1017..1051
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1051 AA; 115347 MW; 9E4D9B2F621C0FA4 CRC64;
MLRLQAHTSR PKVPHRAEDA AAAAIFPNRK RKQHEPCASA SRTDGSAGAP GTLVRQTHGS
AAGMASAAVE TFVAKHLYLL ELERDAEVEE RRSWQENISL KELQSRGVCL LKLQVSSQRT
GLYGRLLVTF EPRRCGPVAV LPSNSFTSGD IVGLYDTANE GRQLATGILT RITQKSVSVA
FDESHDFQLT LDRENFYRLL KLANDVTYKR LKKALVTLKK YHSGPASSLI EVLFGGSDPS
PAQEIPPLKF YNTALDASQK EAVSFALSQK ELAIIHGPPG TGKTTTVVEV ILQAVKQGLK
VLCCAPSNVA VDNLVERLAL RKLRILRLGH PARLLEPIQQ HSLDAVLARS DSAQIVADIR
KDIDQIFVKN KKTQEKKDKS NFRSEIKQLR KELKEREEAA MVESLTAASV VLATNTGASP
DGPLKLLPES YFDVVVIDEC GQALEASCWI PLLKARKCIL AGDHKQLPPT TVSHQAAQEG
LSLSLMERLA EEHGDKVVRT LTVQYRMHQA IMHWASEAMY GGQLTAHSSV AGQLLRDLPG
VTATEETGIP LLLVDTASCG LFELEEEDDQ SKGNPGEVRL VSLHIQALVD AGVQASDIAV
ITPYNLQVDL LRQSLEHKHP ELEIKSVDGF QGREKEAVVL SFVRSNRKGE VGFLAEDRRI
NVAVTRARRH VALVCDSRTV NNHPFLKTLV DYVTQHGEVR TAFEYLDDIV PVNYAHEGPQ
GHSQAAAKPR GPTSSARKLP RSGRPEGGQE AGAAARQHQK KPGTKPLASE VPSQPRFNGD
SQEGPRVADG TERFRAMIEE FVASEEMQLR FPASLNSHDR LRVHQIAEEY GLRHDSAGEG
KARCITVSKR GHGVSSRAPL PAVASSPGQP ERPPEEQCTQ AGVDLKVLHL ERLQRVQGTQ
EQPAKKEQPV LGSGLQKFPE KKKKKEAKGR PARDQPTEED FDALVSAAVK ADNTCSFAKC
SASVVTLGQF CQFCGHRYCL SHHLPEVHGC GEKARVHARQ RISREGVLYA GSGTKDRSLD
PAKRAQLQRR LDKKLGELSS QRASKRKEKG T
//
