ID H0V9J4_CAVPO Unreviewed; 1588 AA.
AC H0V9J4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Adhesion G protein-coupled receptor B2 {ECO:0000313|Ensembl:ENSCPOP00000006490.3};
GN Name=ADGRB2 {ECO:0000313|Ensembl:ENSCPOP00000006490.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000006490.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000006490.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000006490.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02028604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000006490; -.
DR Ensembl; ENSCPOT00000007270.3; ENSCPOP00000006490.3; ENSCPOG00000007198.4.
DR VEuPathDB; HostDB:ENSCPOG00000007198; -.
DR GeneTree; ENSGT00940000160103; -.
DR HOGENOM; CLU_003751_1_0_1; -.
DR InParanoid; H0V9J4; -.
DR OMA; GNILMPM; -.
DR TreeFam; TF331634; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000007198; Expressed in frontal cortex and 12 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0033173; P:calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR CDD; cd15988; 7tmB2_BAI2; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 4.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR10239:SF32; ADHESION G PROTEIN-COUPLED RECEPTOR B2; 1.
DR PANTHER; PTHR10239; ISTHMIN-2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00090; TSP_1; 4.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 4.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 4.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 4.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..39
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 40..1588
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012113153"
FT TRANSMEM 942..963
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 975..996
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1008..1032
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1044..1062
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1082..1109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1130..1148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1160..1180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1187..1207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 527..597
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 938..1212
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 235..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 776..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1364..1389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1430..1459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1515..1588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1588 AA; 172539 MW; EA8B1774C1E23503 CRC64;
MRLILPADLC LSPQGKGHRM TPACPLLLSV ILSLRLATAF DPAPSACSAL ASGVLYGAFS
LQDLFPTIAS GCSWTLENPD PTKYSLYLRF NRQEQVCTHF APRLLPLDHY LANFTCLRPS
PEEAGAQAEP AVGQTGEEEA AAAAGLELCG GSGPFTFLHF DKNFVQLCLS AEPSEAPRLL
APAALAFRFV EVLLINNNNS SQFTCGVLCR WSEECGRAAG RACGFAQPGC SCPGEAGASP
ATTPPGPPAA HTLSNALVPG VPAPPAEADL HSGSSNDLFT TEMRYGEEPE EEPKVKTQWP
RSADEPGLYM AQTGDPAAEE WSPWSVCSLT CGQGLQVRTR SCVSSPYGTL CSGPLRETRP
CNNSATCPVN GVWEEWGSWS LCSRSCGRGS RSRMRTCVPP QHGGKACEGP ELQTKLCSMA
ACPVEGQWLE WGPWGPCSSS CANGTQQRSR KCSVAGPAWA TCTGALTDTR ECSNLECPAT
DGKWGPWNAW SLCSKTCDTG WQRRFRMCQA SGTQGYPCEG TGEEVKPCSE KRCPAFHEMC
RDEYVMLMTW KKAAAGEIIY NKCPPNATGS ASRRCLLSAQ GVAYWGLPSF ARCISHEYRY
LYLSLREHLA KGQRMLAGEG MSQVVRSLQE LLARRTYYSG DLLFSVDILR NVTDTFKRAT
YVPSADDVQR FFQVVSFMVD EENKDKWDDA QQVSPGSVHL LRVVEDFIHL VGDALKAFQS
SLIVTDNLVI SIQREPISAV SSDITFPMRG RRGMKDWVRH SEDRLFLPKE VLSLSSPANP
STAGAAGNPG KVRGPGTVPP GPGHSHQRLL PADPDDSSYF VIGAVLYRTL GLILPPPRPP
LAVTSRVMTV TVRPPTQPPS EPLITVELSY IINGTTDPHC ASWDYSRADA SSGDWDTESC
QTLETQAAHT RCQCQHLSTF AVLAQPPKDL TLELAGAPSV PLVIGCAVSC MALLTLLAIY
AAFWRFIKSE RSIILLNFCL SILASNILIL VGQSRVLSKG VCTMTAAFLH FFFLSSFCWV
LTEAWQSYLA VIGRMRTRLV RKRFLCLGWG LPALVVAVSV GFTRTKGYGT SSYCWLSLEG
GLLYAFVGPA AVIVLVNMLI GIIVFNKLMA RDGISDKSKK QRAGSERCPW ASLLLPCSAC
GAVPSPLLSS ASARNAMASL WSSCVVLPLL ALTWMSAVLA MTDRRSVLFQ ALFAVFNSAQ
GFVITAVHCF LRREVQDVVK CQMGVCRADE SEDSPDSCKN GQLQILSDFE KDVDLACQTV
LFKEVNTCNP STITGTLSRL SLDEDEEPKS CLVGPEGGLS FSPLPGNILV PMAASPGLGE
PPPPQETNPV YMCGEGGLRQ LDLTWLRPTE PGSEGDYMVL PRRTMSLQPG SGGGGGEDAP
RARPEGTPRR AAKALTHTEG YPSFLSVEHS GLGLGPAYGS LQNPYGMTFQ PPPPTPSARQ
VPEPGERSRT MPRTVPGSTM KLGSLERKKL RYSDLDFEKV MHTRKRHSEL YHELNQKFHT
FDRYHSQSAA KHESPWAGAG GVAEGIHEKP SPGERPGLSQ HRRHQSWSTF KSMTLGSLPP
KPRERLTLHR AAAWEPTEPP DGDFQTEV
//
