GenomeNet

Database: UniProt
Entry: H0VA81_CAVPO
LinkDB: H0VA81_CAVPO
Original site: H0VA81_CAVPO 
ID   H0VA81_CAVPO            Unreviewed;       980 AA.
AC   H0VA81;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   05-JUN-2019, entry version 51.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000006751};
GN   Name=SEZ6 {ECO:0000313|Ensembl:ENSCPOP00000006751};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000006751};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000006751}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000006751};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000006751}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000006751};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   EMBL; AAKN02033335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02033336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCPOT00000007556; ENSCPOP00000006751; ENSCPOG00000007483.
DR   eggNOG; ENOG410IS3V; Eukaryota.
DR   eggNOG; ENOG410YA6K; LUCA.
DR   GeneTree; ENSGT00940000156995; -.
DR   InParanoid; H0VA81; -.
DR   TreeFam; TF330037; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000007483; Expressed in 1 organ(s), highest expression level in brain.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd00033; CCP; 5.
DR   CDD; cd00041; CUB; 3.
DR   Gene3D; 2.60.120.290; -; 2.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   Pfam; PF00431; CUB; 2.
DR   Pfam; PF00084; Sushi; 5.
DR   SMART; SM00032; CCP; 5.
DR   SMART; SM00042; CUB; 2.
DR   SUPFAM; SSF49854; SSF49854; 3.
DR   SUPFAM; SSF57535; SSF57535; 5.
DR   PROSITE; PS01180; CUB; 2.
DR   PROSITE; PS50923; SUSHI; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00059,
KW   ECO:0000256|SAAS:SAAS00887447}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    980       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5012949087.
FT   TRANSMEM    913    935       Helical. {ECO:0000256|SAM:Phobius}.
FT   REGION       87    198       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H0VA81}.
FT   COMPBIAS     92    106       Pro-rich. {ECO:0000256|MobiDB-lite:
FT                                H0VA81}.
FT   COMPBIAS    107    139       Polar. {ECO:0000256|MobiDB-lite:H0VA81}.
FT   DISULFID    416    443       {ECO:0000256|PROSITE-ProRule:PRU00059}.
FT   DISULFID    738    765       {ECO:0000256|PROSITE-ProRule:PRU00302}.
SQ   SEQUENCE   980 AA;  106353 MW;  08E4DFDD645D741F CRC64;
     MRPAALLLLP SLLALLAHGL SSEAPTMGEG QATGIKETDG ELTVAPTPEQ PERGVHFVTT
     APTLKLLNHH PLLEEFLQEG LETGEEGLRP ALPFQPDPPT PFTPSPLPRL TNQDSRPVFT
     SPTPAMAEEP TQPQSREGRW SVGSELPVLH ITAPLPPGPS LAVPTLYPGE RPSTTPPSRA
     WTPTQEGPGD MGRPWAPEAL SQTTGLGMEG TIVTSTASGD DEETTTTTTI ITTTITTVQP
     PGPCSWNFSG PEGFLDSPQA YSSPSDVGLD CFYYISVYPG YGVEIKVQNI SLREGEMVTV
     EGLGGPDPLP LANQSFLLRG QVIRSPTHQA ALRFQSLPPP AGPGTFHFHY QAYLLSCHFP
     RRPAYGDVTV TSLHPGGSAH FHCATGYQLK GARLITCLNA TQPFWDSQEP VCIAACGGVI
     RNATTGRIVS PGYPGNYSNN LTCHWLLEAP ESQRLHLHFE KVSLAEDDDR LIIRNGDNVE
     APPVYDSYEV EYLPIEGLLS SGRHFFVELS TDSSGAAAGM ALRYEAFQQG HCYEPFVKYG
     NFSSSAPSYP VGTTVEFSCD PGYTLEQGSI IIECVDPHDP QWNETEPACR AVCSGEITDS
     AGVVLSPNWP EPYGRGQDCI WGVHVEEDKR IMLDVRVLRI GPGDVLTFYD GDDLTARVLG
     QYSGPRGHFK LFTSMADVTI QFQSDPGTSV LGYQQGFVIH FFEVPRNDTC PELPEIPNGW
     KNPSQPELVH GTVVTYQCYP GYQVVGSSVL MCQWDLSWSE DLPSCQRVTS CHDPGDVEHS
     RRLISSPKFP VGATVQYICD QGFVLTGSGI LTCHDRQAGS PKWSDRAPKC LLEQLKPCHG
     LSTPKNGAQN PEKRLHPAGA TVHFSCAPGY VLKGQASIKC VPGHPSHWSD PPPICRAVAK
     APATSRTLDA AHIAAAIFLP LVAMVLLVGG VYLYFSRLQG KSPLQLSQTH APPYNRITVE
     SAFDNPTYET GEMREYEVSI
//
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