GenomeNet

Database: UniProt
Entry: H0VAW4_CAVPO
LinkDB: H0VAW4_CAVPO
Original site: H0VAW4_CAVPO 
ID   H0VAW4_CAVPO            Unreviewed;      1463 AA.
AC   H0VAW4;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   31-JUL-2019, entry version 60.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000007021};
GN   Name=ARHGAP5 {ECO:0000313|Ensembl:ENSCPOP00000007021};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000007021};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000007021}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007021};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000007021}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007021};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AAKN02047605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02047606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCPOT00000007872; ENSCPOP00000007021; ENSCPOG00000007798.
DR   eggNOG; KOG4271; Eukaryota.
DR   eggNOG; ENOG410XR4E; LUCA.
DR   GeneTree; ENSGT00940000154553; -.
DR   InParanoid; H0VAW4; -.
DR   TreeFam; TF324451; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000007798; Expressed in 3 organ(s), highest expression level in brain.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.440; -; 3.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR002713; FF_domain.
DR   InterPro; IPR036517; FF_domain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039007; pG1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR032835; RhoGAP-FF1.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR039006; RhoGAP_pG2.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF01846; FF; 1.
DR   Pfam; PF00071; Ras; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF16512; RhoGAP-FF1; 1.
DR   SMART; SM00441; FF; 4.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF81698; SSF81698; 1.
DR   PROSITE; PS51676; FF; 4.
DR   PROSITE; PS51852; PG1; 1.
DR   PROSITE; PS51853; PG2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT   DOMAIN      267    325       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      366    420       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      427    481       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      482    548       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      590    763       PG1 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51852}.
FT   DOMAIN      779    944       PG2 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51853}.
FT   DOMAIN     1223   1410       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   REGION      975   1050       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1068   1090       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1129   1217       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      309    329       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS   1024   1038       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1136   1160       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1192   1209       Basic. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   1463 AA;  167651 MW;  0206A8FB4CA96320 CRC64;
     MMAKNKEPRP PSYTISVVGL SGTEKDKGNC GVGKSCLCNR FVRSKADEYY PEHTSVLSTI
     DFGGRVVNND HFLYWGDITQ NGEDGVECKI HVIEQTEFID DQTFLPHRST NLQPYIKRAA
     ASKLQSAEKL MYICTDQLGL EQDFEQKQMP EGKLNVDGFL LCIDVSQGCN RKFDDQLKFV
     NNLFVQLSKS KKPVIIAATK CDECVDHYLR EVQAFASNKK NLLVVETSAR FNVNIETCFT
     ALVQMLDKTR GKPKIIPYLD AYKTQRQLVV TATDKFEKLV QTVRDYHATW KTVSNKLKNH
     PDYEEYINLE GTRKARNTFS KHIEQLKQEH IRKRREEYIS TLPRAFNTLL PNLEEIEHLN
     WSEALKLMEK RTDFQLCFVV LEKTPWDETD HIDKIHDRRI PFDLLSTLEA EKVYQNHVQH
     LISEKRRVEM KEKFKKTLEK IQFISPGQPW EEVICFVMED EAFKYITEAD SKEVYSRHQR
     EIVEKAKEEF QEMLFEHSEL FYDLDLNATP SSDKMSEIHT VLSEEPRYKA LQKLAPDRES
     LLLKHIGFVY HPTKETCLSG QNCTDIKVEQ LLASSLLHLD HSRLRLYHDS SNIDKVNLFI
     LGKDGLAQEL ANEIRTQSTD DEYALDGKIY ELDLRPVDAK SPYILSQLWT AAFKPHGCFC
     VFNSIESLSF IGEFIGKVRT EASQIRKDKY MANLPFTLIL ANQRDSISKN LPILRHQGQQ
     LANKLQCPFV DVPTSTYPRK FNESQIKQAL RGVLESVKHN LDVVSPVPTN KDVLEADLRI
     IMCAMCGDPF RVDLILSPFL DSHSCSAAQA GQNNSLMLDK IIGEKRRRIQ ITILSYHSSI
     GVRKDELVHG YILVYSAKRK ASMGMLRAFL SEVQDTIPVQ LVAVTDSQAD FFENEAIKEL
     MTEGEHIATE ITAKFTALYS LSQYHRQTEV FTLFFSDVLE KKNMIENSYL SDNTRELTHQ
     SEDVFLPSPR DCFPYNNYPD SDDDTEAPPP YSPIGDDVQL LPTSSDRSKT RLDLEGNEYP
     VHSTPNCHDH ERNHKVPPPI KPKPVVPKTN VKKLDPNLLK TIEAGIGKNP RKQTSRVPLA
     HPEDVDSSDN YAEPIDTIFK QKGYSDEIYV VPDDSQNRII KIRNSFVNTQ GDEENGFSDR
     SSKSHGERRK GRHRGSEEDP LLSPVETWKG GIDNPAITSD QEVDDKKTKK KPHKVKEDKK
     QKKKTKNFNP PTRRNWESNY FGMPLQDLVT AEKPIPLFVE KCVEFIEDTG LCTEGLYRVS
     GNKTDQDNIQ KQFDQDHNIN LVSMEVTVNA VAGALKAFFT DLPDPLIPYS LHPELLEAAK
     ILDKTERLHA LKEIVKKFHP VNYDVLRYVI THLNRVSQQN KINLMTADNL SICFWPTLMR
     PDFENREFLS TTKIHQSVVE TFIQQCQFFF YNGEIVETAN TVAPPPPSNP GQLVESVVPL
     QLPPPLQPQL IQPQLQTDPL GII
//
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