GenomeNet

Database: UniProt
Entry: H0VB77_CAVPO
LinkDB: H0VB77_CAVPO
Original site: H0VB77_CAVPO 
ID   H0VB77_CAVPO            Unreviewed;      4873 AA.
AC   H0VB77;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   28-MAR-2018, entry version 49.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSCPOP00000007144};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSCPOP00000007144};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000007144};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000007144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007144};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000007144}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007144};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02021705; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000007144; -.
DR   Ensembl; ENSCPOT00000008011; ENSCPOP00000007144; ENSCPOG00000007936.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H0VB77; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000007936; -.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 3.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4185   4204       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4405   4425       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4480   4499       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4616   4637       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4674   4695       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4750   4773       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       45    100       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      107    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    215       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      221    278       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      286    343       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      534    744       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      960   1157       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1272   1497       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3928   3963       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      407    427       {ECO:0000256|SAM:Coils}.
FT   COILED     2963   2983       {ECO:0000256|SAM:Coils}.
FT   COILED     3228   3248       {ECO:0000256|SAM:Coils}.
FT   COILED     4317   4350       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4873 AA;  553647 MW;  69F837EFD53B034C CRC64;
     LSICTFVLEQ SLSVRALQEM LANTVEKSEG ASTKNPWPTA QGGGHRTLLY GHAILLRHSY
     SGMYLCCLST SRSSTDKLAF DVGLQEDTTG EACWWTIHPA SKQRSEGEKV RVGDDLILVS
     VSSERYLHLS YGTGSLHVDA AFQQTLWSVA PISSGSEAAQ GYLIGGDVLR LLHGHMDECL
     TVPSGEHGEE QRRTVHYEGG AVSVHARSLW RLETLRVAWS GSHIRWGQPF RLRHVTTGKY
     LSLLEDKNLL LMDKEKADVK STAFTFRSSK EKLDVSVRKE VDGMGTSEIK YGDSVCYIQH
     VDTGLWLTYQ SVDVKSVRMG SIQRKAIMHH EGHMDDGLNL SRSQHEESRT ARVIRSTVFL
     FNRFIRGLDA LSKKVKVPAV DLPIESVSLS LQDLIGYFHP PDEHLEHEDK QNRLRALKNR
     QNLFQEEGMI NLVLECIDRL HVYSSAAHFA DVAGREAGEA WKSILNSLYE LLAALIRGNR
     KNCAQFSGSL DWLISRLERL EASSGILEVL HCVLVESPEA LNIIKEGHIK SIISLLDKHG
     RNHKVLDVLC SLCVCHGVAV RSNQHLICDN LLPGRDLLLQ TRLVNHVSSM RPNIFLGISE
     GSAQYKKWYY ELMVDHTEPF VTAEATHLRV GWASTEGYSP YPGGGEEWGG NGVGDDLFSY
     GFDGLHLWSG CIARTVSSPN QHLLKTDDVI SCCLDLSAPS ISFRINGQPV QGMFENFNID
     GLFFPVVSFS AGIKVRFLLG GRHGEFKFLP PPGYAPCYEA VLPKEKLKVE HSREYKQERT
     YTRDLLGPTV SLTQAAFTPI PVDTTQIVLP PHLERIREKL AENIHELWVM NKIELGWQYG
     PVRDDNKRQH PCLVEFSKLP EQERNYNLQM SLETLKTLLA LGCHVGLSDE HAEEKVKKMK
     LPKNYQLTSG YKPAPMDLSF IKLTPAQEAM VDRLAENAHN VWARDRIRQG WTYGIQQDVK
     NRRNPRLVPY TLLDDRTKKS NKDSLREAVR TLLGYGYNLE APDQDHAARA EVCSGTGERF
     RIFRAEKTYA VKAGRWYFEF EAVTAGDMRV GWSRPGCQPD QELGSDERAF AFDGFKAQRW
     HQGNEHYGRS WQAGDVVGCM VDMNEHTMMF TLNGEILLDD SGSELAFKDF DVGDGFIPAC
     SLGVAQVGRM NFGKDVSTLK YFTICGLQEG YEPFAVNTNR DITMWLSKRL PQFLQVPSNH
     EHIEVTRIDG TIDSSPCLKV TQKSFGSQNS STDLMFYRLS MPIECAEVFS KTMAGGLPGA
     GLFGPKNDLE DYDADSDFEV LMKTAHGHLV PDRVDKDKEA SKPEFNNHKD YAQEKPSRLK
     QRFLLRRTKP DYSTSHSARL TEDVLADDRD DYDYLMQTST YYYSVRIFPG QEPANVWVGW
     ITSDFHQYDT GFDLDRVRTV TVTLGDEKGK VHESIKRSNC YMVCAGESMS PGQGRNNNGL
     EIGCVVDAAS GLLTFIANGK ELSTYYQVEP STKLFPAVFA QATSPNVFQF ELGRIKNVMP
     LSAGLFKSEH KNPVPQCPPR LHVQFLSHVL WSRMPNQFLK VDVSRISERQ GWLVQCLDPL
     QFMSLHIPEE NRSVDILELT EQEELLKFHY HTLRLYSAVC ALGNHRVAHA LCSHVDEPQL
     LYAIENKYMP GLLRSGYYDL LIDIHLSSYA TARLMMNNEF IVPMTEETKS ITLFPDENKK
     HGLPGIGLST SLRPRMQFSS PSFVSISNEC YQYSPEFPLD ILKAKTMQML TEAVKEGSLH
     ARDPVGGTTE FLFVPLIKLF YTLLIMGIFH NEDLKHILQL IEPRVFKEAA CVEEEGDVLE
     KELSTEDSKL EGAGEEDVKV GKAPKEGLLQ MKLPEPVKLQ MCLLLQYLCD CQVRHRIEAI
     VAFSDDFVAK LQDNQRFRYN EVMQALNMSA ALTARKTKEF RSPPQEQINM LLNFKDDKSE
     CPCPEEIRDQ LLDFHEDLMT HCGIELDEDG SLDGNSDLTI RGRLLSLVEK VTYLKKKQSE
     KPVASDAKKS SSLQQLISET MVRWAQESII EDPELVRAMF VLLHRQYDGI GGLVRALPKT
     YTINGVSVED TINLLASLGQ IRSLLSVRMG KEEEKLMIRG LGDIMNNKVF YQHPNLMRAL
     GMHETVMEVM VNVLGGGESK VKEILTHPKT MTQASSPAMR GSTPLDVAAA SVMDNNELAL
     ALREPDLEKV VRYLAGCGLQ SCQMLVSKGY PDIGWNPVEG ERYLDFLRFA VFCNGESVEE
     NANVVVRLLI RRPECFGPAL RGEGGNGLLA AMEEAIKIAE DPSRDGPSPT SGSSKTLDTE
     EEEDDTIHMG NAIMTFYAAL IDLLGRCAPE MHLIHAGKGE AIRIRSILRS LIPLGDLVGV
     ISIAFQMPTI AKDGNVVEPD MSAGFCPDHK AAMVLFLDRV YGIEVQDFLL HLLEVGFLPD
     LRAAASLDTA ALSATDMALA LNRYLCTAVL PLLTRCAPLF AGTEHHASLI DSLLHTVYRL
     SKGCSLTKAQ RDSIEVCLLS ICGQLRPSMM QHLLRRLVFD VPLLNEHAKM PLKLLTNHYE
     RCWKYYCLPG GWGNFGAASE EELHLSRKLF WGIFDALSQK KYEQELFKLA LPCLSAVAGA
     LPPDYMESNY VSMMEKQSSM DSEGNFNPQP VDTSNITIPE KLEYFINKYA EHSHDKWSMD
     KLANGWIYGE IYSDSSKIQP LMKPYKLLSE KEKEIYRWPI KESLKTMLAW GWRIERTREG
     DSMALYNRTR RISQTSQVSV DAAHGYSPRA IDMSNVTLSR DLHAMAEMMA ENYHNIWAKK
     KKLELESKGG GNHPLLVPYD TLTAKEKAKD REKAQDILKF LQINGYAVSR GFKDLELDTP
     SIEKRFAYSF LQQLIRYVDE AHQYILEFDG GSRSKGEHFP YEQEIKFFAK VVLPLIDQYF
     KNHRLYFLSA ASRPLCSGGH ASNKEKEMVT SLFCKLGVLV RHRISLFGND ATSIVNCLHI
     LGQTLDARTV MKTGLESVKS ALRAFLDNAA EDLENTMENL KQGQFTHTRN QPKGVTQIIN
     YTTVALLPML SSLFEHIGQH QFGEDLILED VQVSCYRILT SLYALGTSKS IYVERQRSAL
     GECLAAFAGA FPVAFLETHL DKHNVHSIYN TKSSRERAAL NLPPNVEDVC PNIPSLEKLM
     EEIVELAESG IRYTQMPHVM EVVLPMLCSY MSRWWEHGPE NNPERSEMCC TALNSEHMNT
     LLGNILKIIY NNLGIDEGAW MKRLAVFSQP IINKVKPQLL KTHFLPLMEK LKKKAAMVVA
     EEDHLKAEAR GDMSEAELLI LDEFTTLARD LYAFYPLLIR FVDYNRAKWL KEPNPEAEEL
     FRMVAEVFIY WSKSHNFKRE EQNFVVQNEI NNMSFLITDT KSKMSKAAVS DQERKKMKRK
     GDRYSMQTSL IVAALKRLLP IGLNICAPGD QELIALAKNR FSLKDTEDEV RDIIRSNIHL
     QGKLEDPAIR WQMALYKDLP NRTEDTSDPE RTVERVLDIA NVLFHLEQKS KCIGRRYYNL
     GKHPQRSKKA VWHKLLSKQR KRAVVACFRM APLYNLPRHR AVNLFLQGYE KSWIETEEHY
     FEDKLIEDLA KPGAKPPEED EAAKRVDPLH QLILLFSRTA LTEKCKLEED FLYMAYADIM
     AKSCHDEEDD DGEEEVKSFE EKEMEKQKLL YQQARLHDRG AAEMVLQTIS ASKGETGPMV
     AATLKLGIAI LNGGNSTVQQ KMLDYLKEKK DVGFFQSLAG LMQSCSVLDL NAFERQNKAE
     GLGMVTEEGS GEKVLQDDEF TCDLFRFLQL LCEGHNSDFQ NYLRTQTGNN TTVNIIISTV
     DYLLRVQESI SDFYWYYSGK DVIDEQGQRN FSKAIQVAKQ VFNTLTEYIQ GPCTGNQQSL
     AHSRLWDAVV GFLHVFAHMQ MKLSQDSSQI ELLKELMDLQ KDMVVMLLSM LEGNVVNGTI
     GKQMVDMLVE SSNNVEMILK FFDMFLKLKD LTSSDTFKEY DPDGKGVISK RDFHKAMESH
     KHYTQSETEF LLSCAETDEN ETLDYEEFVK RFHEPAKDIG FNVAVLLTNL SEHMPNDTRL
     QTFLELAESV LNYFQPFLGR IEIMGSAKRI ERVYFEISES SRTQWEKPQV KESKRQFIFD
     VVNEGGEKEK MELFVNFCED TIFEMQLAAQ ISESDLNERS TNKEESEKER LEEQGPRMGF
     FSILTVRSAL LALRYNILTL MRMLSLKSLK KQMKKMKKMT MKDMVTAFFS SYWSVFVTLL
     HFVASVCRGF FRIVCSLLLG GSLVEGAKKI KVAELLANMP DPTQDEVRGD GEEGERKPME
     TPLPSEDLTD LKELAEESDL LSDIFGLDLK REGGQYKLIP HNPNAGLGDL MSNPVPIPEV
     QEKFQEQKTK EEEKEEKEET KSEPEKAEGE DGEKEEKAKE DKGKQKLRQL HTHRYGEPEV
     PESAFWKKII AYQQKLLNYF ARNFYNMRML ALFVAFAINF ILLFYKVSTA SVAEGKELPT
     RSPSESAKVT TSLDSSSHRI IAVHYVLEES SGYMEPTLRI LAILHTVISF FCIIGYYCLK
     VPLVIFKREK EVARKLEFDG LYITEQPSED DIKGQWDRLV INTQSFPNNY WDKFVKRKVM
     DKYGEFYGRD RISELLGMDK AALDFSDARE KKKPKKDSSL SAVLNSIDVK YQMWKLGVVF
     TDNSFLYLAW YMTMSVLGHY NNFFFAAHLL DIAMGFKTLR TILSSVTHNG KQLVLTVGLL
     AVVVYLYTVV AFNFFRKFYN KSEDGDTPDM KCDDMLTCYM FHMYVGVRAG GGIGDEIEDP
     AGDEYEIYRI IFDITFFFFV IVILLAIIQG LIIDAFGELR DQQEQVKEDM ETKCFICGIG
     NDYFDTVPHG FETHTLQEHN LANYLFFLMY LINKDETEHT GQESYVWKMY QERCWEFFPA
     GDCFRKQYED QLN
//
DBGET integrated database retrieval system