ID H0VBG2_CAVPO Unreviewed; 198 AA.
AC H0VBG2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Proline rich and Gla domain 2 {ECO:0000313|Ensembl:ENSCPOP00000007243.2};
GN Name=PRRG2 {ECO:0000313|Ensembl:ENSCPOP00000007243.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000007243.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000007243.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007243.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02046407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003465556.2; XM_003465508.3.
DR RefSeq; XP_013003359.1; XM_013147905.1.
DR RefSeq; XP_013003360.1; XM_013147906.1.
DR AlphaFoldDB; H0VBG2; -.
DR STRING; 10141.ENSCPOP00000007243; -.
DR Ensembl; ENSCPOT00000008126.3; ENSCPOP00000007243.2; ENSCPOG00000008051.4.
DR GeneID; 100725720; -.
DR KEGG; cpoc:100725720; -.
DR CTD; 5639; -.
DR VEuPathDB; HostDB:ENSCPOG00000008051; -.
DR eggNOG; ENOG502RZZF; Eukaryota.
DR GeneTree; ENSGT00950000183084; -.
DR HOGENOM; CLU_084796_1_0_1; -.
DR InParanoid; H0VBG2; -.
DR OMA; ANHWDFE; -.
DR OrthoDB; 5265862at2759; -.
DR TreeFam; TF332123; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000008051; Expressed in thyroid gland and 13 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 4.10.740.10; Coagulation Factor IX; 1.
DR InterPro; IPR017857; Coagulation_fac-like_Gla_dom.
DR InterPro; IPR035972; GLA-like_dom_SF.
DR InterPro; IPR000294; GLA_domain.
DR PANTHER; PTHR24278; COAGULATION FACTOR; 1.
DR PANTHER; PTHR24278:SF30; TRANSMEMBRANE GAMMA-CARBOXYGLUTAMIC ACID PROTEIN 2; 1.
DR Pfam; PF00594; Gla; 1.
DR PRINTS; PR00001; GLABLOOD.
DR SMART; SM00069; GLA; 1.
DR SUPFAM; SSF57630; GLA-domain; 1.
DR PROSITE; PS00011; GLA_1; 1.
DR PROSITE; PS50998; GLA_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..198
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003542649"
FT TRANSMEM 110..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..98
FT /note="Gla"
FT /evidence="ECO:0000259|PROSITE:PS50998"
FT REGION 144..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 198 AA; 21980 MW; A913F000F8DCC8BB CRC64;
MRGHPSLLLL YMGLATCLDS SPSGEQDQGP EVFLGPSEAQ GFLKGHRRVP RANHWDLELF
TPGNLERECY EEQCSWEEAR ECFEDNTQTN TFWETYLYNG KGGQRRVDGA ALAVGLTSGI
MLIILAALGA FWYLHYRQRQ TSSQQLSPQE TNLISPLNPP TPLAAPRPPG LPTYEQALAA
SGVHDAPPPP YSSLRRPQ
//
