ID H0VBK2_CAVPO Unreviewed; 987 AA.
AC H0VBK2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Rho guanine nucleotide exchange factor 10 like {ECO:0000313|Ensembl:ENSCPOP00000007285.3};
GN Name=ARHGEF10L {ECO:0000313|Ensembl:ENSCPOP00000007285.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000007285.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000007285.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007285.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02028781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02028782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02028783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02028784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02028785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VBK2; -.
DR Ensembl; ENSCPOT00000008177.3; ENSCPOP00000007285.3; ENSCPOG00000008102.4.
DR VEuPathDB; HostDB:ENSCPOG00000008102; -.
DR GeneTree; ENSGT00940000153798; -.
DR HOGENOM; CLU_001213_1_0_1; -.
DR TreeFam; TF331430; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000008102; Expressed in cerebellum and 13 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF16; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10-LIKE PROTEIN; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 96..178
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 841..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 892..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 193..226
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 841..857
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 987 AA; 107716 MW; 74A3A7BEDCA8C181 CRC64;
MLPSSSWGKR KPRSRRLGWV RSDARGGIMW ARQEGLRHPY SHAVVRCPSS SSSSVSCSGD
SEEEDMGLLE VSVTDIKPPA PELGPMPDGL SPQQVVRRHI LGSIVQSEGS YVESLKRILQ
DYRNPLMEME PKVLSVRKCQ VVFFRVKEIL HCHSMFQIAL SSRVAEWDST EKIGDLFVAS
DMLKNTPRGH PDRLSLQLAL TELETLAEKL NEQKRLADQV AEIQQLTKSV SDRSSLNKLL
TSGQRQLLLC ETLTETVYGD RGQLIKSKER RVFLLNDMLV CANINFKGQL EISSLVPLGP
KYVVKWNTAL PQVQVVEVGQ DGGAYDKDNV LIQHSGAKKA SASGQAQNKV YLGPPRLFQE
LQDLQKDLAV VEQITLLVST LHGTYQNLNM TVAQDWCLAL QRLLRVKEEE IHSANKCRLR
LLLPGKPDKS GRPISFMVVF ITPNPLSKIS WVNRLHLAKI GLREENQPGW LCPDEDRKSK
APFWCPILAC CVPAFSSRAL NLQLGALVHS PVNCPLLGFS AVSTSLPQGY LWVGGGQEGA
GGQVEIFSLN RPSPRTVKSF PLAAAVLCME YIPEPEEDPE GGDESQVAAD PTAGTVHPTI
CLGLQDGSIL LYGSVDTGTQ CLATCRSPGL QPVLCLRHSP SHLLAGLQDG TLAAYPRTSG
AVPWDLESPP VCLTVGPGPI RTLLSLEDAV WASCGSRVTV LDATSLRTQQ SFEAHQDEAV
SVTHMVKAGS GVWMAFSSGS SIRLFHTETL EHLQEINIAT RTTFLLPGQK HLCVTSLLIC
QGLLWVGTDQ GVIVLLPVPR LEGIPKITGK GMVSLNGHCG PVAFLAVATS ILAPDILRSD
HEEAEGPRAE EDKLDGQAQE PAPVPDSHVG RELTRKKGIL LQYRLRSTAH LPGPLLSMRE
PSPADSSALE HSEEDGSIYE MADDPDVWVR SRPCARDAHR KEICSVAIIS GGQGYRNFSS
GPGVSGRPAP CGETDSTLLI WQVPLML
//
