ID H0VBZ0_CAVPO Unreviewed; 692 AA.
AC H0VBZ0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Myotubularin related protein 11 {ECO:0000313|Ensembl:ENSCPOP00000007436.3};
GN Name=MTMR11 {ECO:0000313|Ensembl:ENSCPOP00000007436.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000007436.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000007436.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007436.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR EMBL; AAKN02003915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003478926.3; XM_003478878.3.
DR AlphaFoldDB; H0VBZ0; -.
DR STRING; 10141.ENSCPOP00000007436; -.
DR Ensembl; ENSCPOT00000008346.3; ENSCPOP00000007436.3; ENSCPOG00000008271.4.
DR GeneID; 100718905; -.
DR KEGG; cpoc:100718905; -.
DR CTD; 10903; -.
DR VEuPathDB; HostDB:ENSCPOG00000008271; -.
DR eggNOG; KOG1089; Eukaryota.
DR GeneTree; ENSGT00940000160276; -.
DR HOGENOM; CLU_021912_1_0_1; -.
DR InParanoid; H0VBZ0; -.
DR OMA; GWQRSQD; -.
DR OrthoDB; 5474662at2759; -.
DR TreeFam; TF315197; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000008271; Expressed in uterine cervix and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR InterPro; IPR022587; MTMR12-like_C.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF51; MYOTUBULARIN-RELATED PROTEIN 11; 1.
DR Pfam; PF12578; 3-PAP; 1.
DR Pfam; PF06602; Myotub-related; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 193..636
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 692 AA; 78107 MW; 601BEC3F02863A6F CRC64;
MWWGGRGQSF NIASPKEEPE MGGSRMLENR SGQPGSCLAS GCLPGEQILA WSPGLRKGLE
PELPGTLICT NFRVTFQPCG WQRSQDTPLS SEYDFALVNI GRLEAVSGLS RVQLLRPGSQ
LKFIPEEILI HGQDFRLLRV GFEAGGLEPQ AFQVTMAIVQ ARAQSSQTQL YVGITQRKAA
QGSGFRKPPI PLLETLEDWE SERKKQGARG WRLSTVNERF DIATSLPRYF WVPNRTLDNE
VRRAFGHFHQ GRGPRLSWHH PGGSDLLRCG GFYTASDPNK EDIRAVESML QAGHSDVVLV
DTMDELPSLA DVQLAHLKLR ALCLPDSSVS EDKWLSALEG TRWLDHVRSC LRKASDISVL
VTSRVRSVVL QERGDRDFNG LLSSLVQLLS APEARTLFGF QALVQREWVA AGHPFLTRLG
GTGASEEAPV FLLFLDCVWQ LLQQFPVEFE FSEFFLLALH DSVRVPDTLT FLRNTPWERG
KQSAQFNSYT QMYTPEYSSP SAEKSVNLQL SVWDWDLRYS NKQILQFHNP RYAREHYPDL
RFPRQQPSLM LPGPPNSVWL FSRGALTPLN QLCPWRDNPS LLTVSSRWLP RPAISSESLA
DQEWGLPSHW GACPLPPGLL LPSYLGPQIR LWKRCYLRGR PEVQMGLSAS TIAGLQDELS
HLQELLKKWT SRISPEDHCN RDDPNNILPQ SR
//
