ID H0VCS5_CAVPO Unreviewed; 241 AA.
AC H0VCS5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=LIGHT {ECO:0000313|EMBL:AFO63170.1};
DE SubName: Full=TNF superfamily member 14 {ECO:0000313|Ensembl:ENSCPOP00000031160.1};
DE Flags: Fragment;
GN Name=TNFSF14 {ECO:0000313|Ensembl:ENSCPOP00000031160.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|EMBL:AFO63170.1};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|EMBL:AFO63170.1}
RP NUCLEOTIDE SEQUENCE.
RA Li C.L., Liu H.Y., Song J.Y., Ai H.X.;
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AFO63170.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23732292; DOI=10.1016/j.gene.2013.05.031;
RA Li C., Chen S., Song J., Liu H., Gu W., Ai H., Zhao B., Zhang S.;
RT "Molecular cloning and characterization of TNFSF14 (LIGHT) and its receptor
RT TNFRSF14 (HVEM) in guinea pig (Cavia porcellus).";
RL Gene 526:374-384(2013).
RN [4] {ECO:0000313|Ensembl:ENSCPOP00000031160.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000031160.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; AAKN02058822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JX023507; AFO63170.1; -; mRNA.
DR RefSeq; XP_003460758.1; XM_003460710.2.
DR STRING; 10141.ENSCPOP00000031160; -.
DR Ensembl; ENSCPOT00000035676.1; ENSCPOP00000031160.1; ENSCPOG00000038693.1.
DR GeneID; 100725147; -.
DR KEGG; cpoc:100725147; -.
DR CTD; 8740; -.
DR VEuPathDB; HostDB:ENSCPOG00000038693; -.
DR eggNOG; ENOG502RZ4W; Eukaryota.
DR GeneTree; ENSGT01060000248544; -.
DR HOGENOM; CLU_070352_5_1_1; -.
DR OMA; LYWRLEE; -.
DR OrthoDB; 5342809at2759; -.
DR TreeFam; TF332169; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000038693; Expressed in liver.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:Ensembl.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0045663; P:positive regulation of myoblast differentiation; IEA:Ensembl.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; IEA:Ensembl.
DR GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; IEA:Ensembl.
DR GO; GO:0010818; P:T cell chemotaxis; IEA:Ensembl.
DR GO; GO:0031295; P:T cell costimulation; IEA:Ensembl.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11471:SF34; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14; 1.
DR Pfam; PF00229; TNF; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 95..241
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFO63170.1"
SQ SEQUENCE 241 AA; 26839 MW; 0C5567D7F3017380 CRC64;
MEDTVVRPSV FVVDGQTDVP FRRLGPRRKQ RCCTPARVGL GLLLLLLGAV LAAQSWFLLQ
LYWRVEEVVA RLPEKDAESW EKLIQERRSH QTNPAAHLTG ANSSLTGSGG PLLWESQLGL
AFLRGLSYRN GALVTTKAGY YYIYSKVQLG GVGCPQGLAS GLPITHGLYK RTPRYPEELE
LLVSRRSPCG RANGSRIWWD SSFLGGVVHL EVGEEVIVRV PDERLIRLRD GTRSYFGAFM
V
//
