ID H0VD28_CAVPO Unreviewed; 1013 AA.
AC H0VD28;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=MLLT10 histone lysine methyltransferase DOT1L cofactor {ECO:0000313|Ensembl:ENSCPOP00000007866.3};
GN Name=MLLT10 {ECO:0000313|Ensembl:ENSCPOP00000007866.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000007866.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000007866.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007866.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02049693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02049694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02049695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02049696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02049697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02049698; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02049699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02049700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02049701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02049702; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VD28; -.
DR STRING; 10141.ENSCPOP00000007866; -.
DR Ensembl; ENSCPOT00000008842.3; ENSCPOP00000007866.3; ENSCPOG00000008764.4.
DR VEuPathDB; HostDB:ENSCPOG00000008764; -.
DR eggNOG; KOG0956; Eukaryota.
DR GeneTree; ENSGT00940000157711; -.
DR HOGENOM; CLU_010286_0_1_1; -.
DR InParanoid; H0VD28; -.
DR OMA; XFSELLN; -.
DR TreeFam; TF316118; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000008764; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031491; F:nucleosome binding; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd20901; CC_AF10; 1.
DR CDD; cd15708; ePHD_AF10; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR049773; AF10-like_CC.
DR InterPro; IPR049775; AF10_ePHD.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR PANTHER; PTHR13793:SF93; PROTEIN AF-10; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 25..144
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 80..143
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 152..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 746..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 688..725
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 302..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1013 AA; 106673 MW; 1B760B70D2B6A64F CRC64;
CYGIVQVPTG PWFCRKCESQ ERAARVRCEL CPHKDGALKR TDNGGWAHVV CALYIPEVQF
ANVSTMEPIV LQSVPHDRYN KTCYICDEQG RESKAATGAC MTCNKHGCRQ AFHVTCAQFA
GLLCEEEGNG ADNVQYCGYC KYHFSKLKKS KRGSNRSYDQ SLSDSSSHSQ DKHHEKEKKK
YKEKDKHKQK HKKQPEPSAA LIPSLTVTTE KTYTSTSNNS ISGSLKRLED TAARFTNANF
QEVSAHTSSG KDVSEPRGSE SKGKKSSAHS SGQRGRKPGG GRNPGVTVSA ASPFPQGGFS
GAPGSVKSSS GSSVQSPQDF LSFTDSDLRN DSYPHSQQSS STKDVHKGES GSQEAGVNSF
SSLIGHPATA AVISQPKSFE NSPGDLSSSS LSTTGYKRAQ TSGIEEETVK EKKRKGNKQS
KHGPGRPKGN KSQENISHLS VSSASPTSSV ASAAGSVASS SLQKSPTLLR NGSLQSLSVG
SSPVGSEIST QYRHDGACPT TTFSELLNAI HNGIYNNGDA GASFPNAVSG SGSSTPVSSS
HLPPQPSGHL QQVGSLSPSA ASAVTAAVAP TQANTLSGSS LSQAPSHMYG SRSNPNSAVA
ALIAQSENSQ TDQDLGDNSH SLVGRGSSPR GSLSPRSPVS NLQIRYDQPS SSTLDSLPPV
AASIEQLLER QWSEGQQFLL EQGTPSDILG MLKSLHQLQV ENRRLEEQIK NLTAKKERLQ
LLNAQLSVPF PAIAVALSPS QQLHPFSAQT APTADSLNSN KSPHIGNSFL PDSSLPVLNQ
DLTSSGQSTS SSSALSTPPP AGQSPAQQVP AVPGVQQING MTVGALAGGM QPVATSIPAA
TAVGGLIGAL PGNQLAINGI VGALNGVMQT PVTLSQNPAP LTHTTVPPNA THPMPATLTN
SASGLGLLSD QHRQILVHQQ QFQQLLSSQQ LTPEQHQAFL YQFIHQHPQH HAPELQPLQL
PGPTQLPMNS LLTGAPAPPL HTATNPFLNI HGDSAGQVTR ISDKTGPVAQ EKS
//
