ID H0VE00_CAVPO Unreviewed; 825 AA.
AC H0VE00;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Intraflagellar transport 88 {ECO:0000313|Ensembl:ENSCPOP00000008226.3};
GN Name=IFT88 {ECO:0000313|Ensembl:ENSCPOP00000008226.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000008226.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000008226.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000008226.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02010337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02010338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02010339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02010340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003477436.1; XM_003477388.3.
DR AlphaFoldDB; H0VE00; -.
DR STRING; 10141.ENSCPOP00000008226; -.
DR Ensembl; ENSCPOT00000009245.3; ENSCPOP00000008226.3; ENSCPOG00000009162.4.
DR GeneID; 100714887; -.
DR KEGG; cpoc:100714887; -.
DR CTD; 8100; -.
DR VEuPathDB; HostDB:ENSCPOG00000009162; -.
DR eggNOG; KOG2003; Eukaryota.
DR GeneTree; ENSGT00390000015473; -.
DR HOGENOM; CLU_010738_1_0_1; -.
DR InParanoid; H0VE00; -.
DR OMA; RIKIMHN; -.
DR OrthoDB; 312444at2759; -.
DR TreeFam; TF313218; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000009162; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0005814; C:centriole; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0030992; C:intraciliary transport particle B; IEA:Ensembl.
DR GO; GO:0045724; P:positive regulation of cilium assembly; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44117; INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG; 1.
DR PANTHER; PTHR44117:SF1; INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG; 1.
DR Pfam; PF12895; ANAPC3; 1.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF13174; TPR_6; 1.
DR Pfam; PF13176; TPR_7; 1.
DR Pfam; PF13181; TPR_8; 2.
DR SMART; SM00028; TPR; 11.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 7.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 233..266
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 272..305
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 485..518
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 519..552
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 553..586
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 587..620
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 621..654
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 725..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..739
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 825 AA; 93268 MW; 866DCCBB290E0B52 CRC64;
MMQNVHLAPE TDEDDLYSGY NDYNPTYDTE ELENDTGFQQ AVRTSHGRRP PITAKIPSTA
VTRPIATGYG SKTSLMSSMG RPMTGAIQDG VTRPMTAVRA AGFTKAALRG SAFDPLGQSR
GPAPPLETKN EDSPEEKIRQ LEKKVNELVE ESCIANSCGD LKLALEKAKD AGRKERVLVR
QREQIASPEN INLDLTYSVL FNLASQYSAN EMYAEALNTY QVIVKNKMFS NSGRLKVNMG
NIYLNQRNYS KAIKFYRMAL DQIPSVQKEM RIKIMQNIGV TFIKTGQYSD AINSFEHIMS
MAPNLKAGFN LILSYFAIGD REKMKKAFQK LIAVPLEIDD DDKYISPSDD PHTNLVIEAI
KNDHLRQMER ERKAMAEKYI MTAAKLIAPV IETSFAVGYD WCVEVVKASQ YVELANDLEI
NKAITYLRQK DFNQAVDTLK MFEKKDSRVK SAAATNLSFL YYLENEFAQA SSYADLAVNS
DRYNPSALTN KGNTVFANGD YEKAAEFYKE ALRNDSSCTE ALYNIGLTYK KLNRLDEALE
CFLKLHAILR NSAQVLYQIA NVYELMEDPN QAIEWLMQLI SVVPTDSKAL SKLGELYDSE
GDKSQAFQYY YESYRYFPSN IEVIEWLGAY YIDTQFCEKA IQYFERASLI QPTQVKWQLM
VASCFRRSGN YQKALDTYKD IHRKFPENAD CLRFLVRLCT DIGLKEVQEY VTKLKRLEKM
KEIREQRIKS GRDSSGSSRG KREGSAGSDS GQTGGAGSKG ERLSVKLRAL PGTNEPYESS
SNREIDASYV DPLGPQIERP KTAAKKRTDE DDFADEELGD DLLPE
//
