ID H0VEJ6_CAVPO Unreviewed; 745 AA.
AC H0VEJ6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Interacts with SUPT6H, CTD assembly factor 1 {ECO:0000313|Ensembl:ENSCPOP00000008446.3};
GN Name=IWS1 {ECO:0000313|Ensembl:ENSCPOP00000008446.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000008446.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000008446.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000008446.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00649}.
CC -!- SIMILARITY: Belongs to the IWS1 family.
CC {ECO:0000256|ARBA:ARBA00037992}.
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DR EMBL; AAKN02006931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VEJ6; -.
DR Ensembl; ENSCPOT00000009490.3; ENSCPOP00000008446.3; ENSCPOG00000009405.4.
DR VEuPathDB; HostDB:ENSCPOG00000009405; -.
DR GeneTree; ENSGT00720000108834; -.
DR HOGENOM; CLU_018182_0_0_1; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000009405; Expressed in heart and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR46010; PROTEIN IWS1 HOMOLOG; 1.
DR PANTHER; PTHR46010:SF1; PROTEIN IWS1 HOMOLOG; 1.
DR Pfam; PF08711; Med26; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 540..618
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT REGION 1..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..419
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..446
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..640
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 745 AA; 83667 MW; 585A63F162CED809 CRC64;
MESSYNSKKY LSEERHGSDS ESEETQKLPG SDSENEELLN GHASDSENEE VQKHTASDSE
TEELHKSAAS DSEPEDALKP QGTDSESEEP PQPPASDSEN EGPPKPQTSD SESEELPKPR
VSDSESEEPP RHQASDSENE ELPKPQISDS ESEEPPRHRA SDSENEELVK PRISDSESED
PPRHQASDSE NEELPKPQIS DSESEEPPRQ QVSDSDNEEL PKPRVSDSEN EEPHKGPASD
SEAEDTATLK QKPQSDDDSD GENKGGDPEV QNDSFHSDSH LAKKQFHSSD SEDEAPKRQK
MDSDEDEEKE GEEARVSKRK AAVLSDSEDE ERTSAKKNRI VSDADDSSDV GSEKSSKKEK
TVASDSEEEA GKELSDKKNE EKDLFGSDSE SGNEEENLIA DIFGESGDEE EEEFTGFNQE
DLEEEKGEPQ VKEAEDSDSD DNIKRGKHMD FLSDFEMMLQ RKKSMSGKRR RNRDGGTFIS
DADDVVSAMI VKMNEAAEED RQLNNQKKPA LKKLTLLPTV VMHLKKQDLK ETFIDSGVMS
AIKEWLSPLP DRSLPALKIR EELLKILQEL PSVSQETLKH SGIGRAVMYL YKHPKESRAN
KDMAGKLINE WSRPIFGLTS NYKGMTREER EQRDLEQMPQ RRRLSSTGGQ TPRRDLEKVL
TGEEKALRPG DPGFCARARV PMPSNKDYVV RPKWNVEMES SRFQATSKKG ISRLDKQMRK
FTDIRKKSRS AHAVKISIEG NKMPL
//
