ID H0VEK2_CAVPO Unreviewed; 958 AA.
AC H0VEK2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Importin 11 {ECO:0000313|Ensembl:ENSCPOP00000008452.3};
GN Name=IPO11 {ECO:0000313|Ensembl:ENSCPOP00000008452.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000008452.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000008452.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000008452.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AAKN02053046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02053047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02053048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02053049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02053050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02053051; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02053052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VEK2; -.
DR STRING; 10141.ENSCPOP00000008452; -.
DR Ensembl; ENSCPOT00000009497.3; ENSCPOP00000008452.3; ENSCPOG00000009412.4.
DR VEuPathDB; HostDB:ENSCPOG00000009412; -.
DR eggNOG; KOG1993; Eukaryota.
DR GeneTree; ENSGT00390000014071; -.
DR HOGENOM; CLU_003886_0_0_1; -.
DR InParanoid; H0VEK2; -.
DR OMA; SFHYVFH; -.
DR TreeFam; TF324336; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000009412; Expressed in heart left ventricle and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006610; P:ribosomal protein import into nucleus; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR PANTHER; PTHR10997:SF7; IMPORTIN-11; 1.
DR PANTHER; PTHR10997; IMPORTIN-7, 8, 11; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 28..100
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
SQ SEQUENCE 958 AA; 110463 MW; B6E0717EE135410A CRC64;
MDLNSASTVV LQVLTQATSQ DTAILKPAEE QLKQWETQPG FYSVLLNIFT NHSLDINVRW
LAVLYFKHGI DRYWRRVAPH ALSEEEKSTL RAGLITNFNE PINQIATQIA VLIAKVARLD
CPRQWPELIP TLIESVKVQD DLRQHRALLT FYHVTKTLAS KRLAADRKLF YDLASGIYTF
ACSLWNHHTD TFLQQVSSGN EVAVLSSLER TLLSLKVLRK LTVNGFVEPH KNMEVMRNIG
VDNVCRDRLE KTIILFTKVL LDFLDQHPFS FIPLIQRSLE FSVSYVFTEV GEGITFERFI
VQCMNLIKMI VKNYAYKPSK NFEDSSPETL EAHKIKMAFF TYPTLTEICR RLVSHYFLLT
EEELTMWEED PEGFTVEETG GDSWKYSLRP CTEVLFIDIF HEYNQTLTPV LLEMMQTLQG
PTNVEDMNAL LIKDAVYNAV GLAAYELFDS VDFDQWFKNQ LLPELQVIHN RYKPLRRRVI
WLIGQWISVK FKSDLRPMLY EAICNLLQDQ DLVVRIETAT TLKLTVDDFE FRTDQFLPYL
ETMFTLLFQL LQQVTECDTK MHVLHVLSCV IERVNMQIRP YVGCLVQYLP LLWKQSEEHN
MLRCAILTTL IHLVQGLGAD SKNLYPFLLP VIQLSTDVSQ PPHVYLLEDG LELWLVTLEN
SPCITPELLR VFQNMSPLLE LSSENLRTCF KIINGYIFLS STEFLQTYAA GLCQSFCELL
KEITTEGQVQ VLEVVENALK VNPVLGPQMF QPILPYVFKG IIEGERYPVV MSTYLGVMGR
VLLQNASFFS SLLNEMAHKF NQEMDQLLGN MIEMWVDRMD NITQPERRKL SALALLSLLP
SENSVIQDKF CGIINISVEG LHDVMTEDPE TGTYKDCMLM SHLEEPKVTE DEEPPTEQDK
RKKMLALKDP VHTVSLQQFI YEKLKAQQEV LGEQGFQSLM ETVDTEIVTQ LQEFLQGF
//
