GenomeNet

Database: UniProt
Entry: H0VET1_CAVPO
LinkDB: H0VET1_CAVPO
Original site: H0VET1_CAVPO 
ID   H0VET1_CAVPO            Unreviewed;       789 AA.
AC   H0VET1;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 65.
DE   RecName: Full=Solute carrier family 26 member 9 {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Anion transporter/exchanger protein 9 {ECO:0000256|RuleBase:RU362052};
GN   Name=SLC26A9 {ECO:0000313|Ensembl:ENSCPOP00000008540.2};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000008540.2, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000008540.2}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000008540.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Ion transporter that can act both as an ion channel and anion
CC       exchanger. Mainly acts as a chloride channel, which mediate uncoupled
CC       chloride anion transport in an alternate-access mechanism where a
CC       saturable binding site is alternately exposed to either one or the
CC       other side of the membrane. Also acts as a DIDS- and
CC       thiosulfate- sensitive anion exchanger the exchange of chloride for
CC       bicarbonate ions across the cell membrane.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAKN02017893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003474831.1; XM_003474783.2.
DR   RefSeq; XP_013013570.1; XM_013158116.1.
DR   AlphaFoldDB; H0VET1; -.
DR   STRING; 10141.ENSCPOP00000008540; -.
DR   Ensembl; ENSCPOT00000009599.3; ENSCPOP00000008540.2; ENSCPOG00000009513.4.
DR   GeneID; 100717762; -.
DR   KEGG; cpoc:100717762; -.
DR   CTD; 115019; -.
DR   VEuPathDB; HostDB:ENSCPOG00000009513; -.
DR   eggNOG; KOG0236; Eukaryota.
DR   GeneTree; ENSGT01100000263544; -.
DR   HOGENOM; CLU_003182_9_4_1; -.
DR   InParanoid; H0VET1; -.
DR   OMA; WKDMMGT; -.
DR   OrthoDB; 1067648at2759; -.
DR   TreeFam; TF313784; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000009513; Expressed in zone of skin and 2 other cell types or tissues.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR   GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR   GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR   GO; GO:0005254; F:chloride channel activity; IEA:Ensembl.
DR   GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF17; SOLUTE CARRIER FAMILY 26 MEMBER 9; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        100..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        174..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        251..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        333..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        377..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        406..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        463..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          519..735
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
SQ   SEQUENCE   789 AA;  86903 MW;  1BD9A3933D93935A CRC64;
     MSQPRPRFVV DRAAYSLTLF DEEFEKKDRT YPLGAKLRHA FRCSSTKIKT VAFGLLPILS
     WLPKYKIKEY LLPDVLGGLS GGCIQVPQGM AFALLANLPA VNGLYSSFFP LLTYFFLGSV
     HQMVPGTFAV ISILVGNICL QLAPESKFRV FNNVTNESYI DTAAMDTERL HVSATLACLT
     AIIQMGLGFM QFGFVAIYLS ESFVRGFMTA AGLQILISVL KYIFGLTVPP YSGPGSIVLT
     FIDICKNLPH TNIASLIFAL ISALILVVVK ELNARYMHKI RFPIPTEVVV VVVATAISGS
     YKMPQKYHMQ IVGHIQHGFP TPVSPVVSQW KDMIGTAFSL AIVGYVINLA MGRTLADKHG
     YSVDSNQEMI ALGCSNFFGS FFKIHVICCA LSVTLAVDAA GGRSQVASLC VSLVVMITML
     VLGSYLYPLP KAVLGALIAV NLKNSLKQLT DPYYLWRKSK LDCCVWVVSF LSSFFLSLPY
     GVAVGVAFSV LVVVFQTQFR NGYVLARVMD TDIYVNPKTY SRVQEIEGIK IITYCAPLYF
     ANSEIFKQKV IAKTGTDPQK VLLAKQKHLR RQEKRMAPTQ QRKSLFMKTK TVSLQELQQD
     FENVTPTDPN NNQTLANGAG ISYVTFSPDT SASPCEPVTS AEPPREPSDI LASVPPFVTF
     HTLVLDMSGV SFVDLMGTKA LAKLSSTFGK IGVKVFLVNI HAQVYNDISH GGVFEDGCVQ
     RKHVFPSIHD AVLFAQENAR EAVPGQNSQR APEDTELSLC DSEEDNPGYW DLEQEMFGSM
     FHTETLTAL
//
DBGET integrated database retrieval system