ID H0VEZ5_CAVPO Unreviewed; 1198 AA.
AC H0VEZ5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSCPOP00000008615.3};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSCPOP00000008615.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000008615.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000008615.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000008615.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; AAKN02048944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02048945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02048946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VEZ5; -.
DR STRING; 10141.ENSCPOP00000008615; -.
DR Ensembl; ENSCPOT00000009685.3; ENSCPOP00000008615.3; ENSCPOG00000009598.4.
DR VEuPathDB; HostDB:ENSCPOG00000009598; -.
DR eggNOG; ENOG502QQ5U; Eukaryota.
DR GeneTree; ENSGT00940000154127; -.
DR HOGENOM; CLU_007621_0_0_1; -.
DR InParanoid; H0VEZ5; -.
DR OMA; IFFAQIK; -.
DR TreeFam; TF331379; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000009598; Expressed in adult mammalian kidney and 11 other cell types or tissues.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0098797; C:plasma membrane protein complex; IEA:Ensembl.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 197..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1054..1078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 597..624
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 664..721
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1198 AA; 135485 MW; E2D5B3969C6F3980 CRC64;
MVSAGPRGRA AWVLAGGALA AALALGVRPD ADRLHPRLFA LPEGREGRYG DTSREGQGTS
ENGVIFQKCA LVSGHSESPA VRVHLVVNNT RAPLSANLSD LLVLDDTSGL AVRDSPGNKT
PDGLQAFKKE FLPVGDSYLV SYTASLDPGA ISTLESLSLP AQLTFQSSML NRTQLQAVLT
ITVAEKITVL PHHGLHAAGF FIGFLLSLVL SWVALFLLVH YRCLPGGLLA LYAENKLEPS
PFASADGISE DLSLNDQMID ILTSEDPRSM LQALEELEIA TLNRADADLE ACRTQISKDI
IGFLLRSLTC GGHLSPQVER RDRFCFEKSS FLLEECDRED GWALTAEWWT WETRKEDRKT
SYQKENAACL SLTSCLFSLQ SAAECSSLLR TLHGLEQEHV WKSLALHQEE DFAQAHRQLA
VFQRTELHGI FFAQIKNAIF KGELKPEAAK TLLQDYSKLQ EHMEELMDFF QATKRYHLSK
RFGHREYLVQ NLQSTETRVQ GILNTAATQL THLIQKHERA GYLDEDQMEM LLERVQMEVF
SVKQKLDNDL KQEKKKLHQK LVMKRRRELL QKHREQRKEQ LSMAEASRAA GDAGQYLQQW
RSMVAEHSAS LEELQETLDQ AALDDVRALT LLLSEKATEE LRRLQSSAMT QELLKRSVPW
LFLQQILEEQ ARELAARTEQ LEAEERARGQ EGVEGVRRRL RDDALEAATQ EQAELRRWEQ
LVFRRLCNAT FSLSEEELLA SRQEVHSCFA QMDRSLALPK VRARVLLHRF QTAWREAELL
KLDQVLAAPE LQTKARKPRS KSKSKAELLK KCTEDKLRLF EEQHLADLAE KVRGELLRER
VQRLEALEAC FAESLVALQF QKAARSTETL SAYTALLSLQ DLLLEELSES EALTKLACSR
ILESHGPVSE LQELERKLEE QLSQQEVAQQ ERALASWQQW ASSGPGVLKE PEEADSDQHI
SSILQQALSK GQQMLECHQQ SLREEQQSSA VLEDLLENME ADTFATLCSQ ELRLAAYLSK
MTMVPGATLR RLLSVVMPTA LQPQLLALLD SVSEKHPEHT VEDPGSGEQP DPGRRRKHHS
WWQALESRLR ADLRSRGLEK MVWARQRKER ILRKTCIPIR DRLVFSGKGS WPHLSLEPIG
ELAPVPIVGT ETIDVLSTGE KLFIFRNPKE PEISLHVPPR KKKNFLNARK ASRALELD
//