ID H0VGG1_CAVPO Unreviewed; 605 AA.
AC H0VGG1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Glycerophosphodiester phosphodiesterase domain containing 5 {ECO:0000313|Ensembl:ENSCPOP00000009201.2};
GN Name=GDPD5 {ECO:0000313|Ensembl:ENSCPOP00000009201.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000009201.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000009201.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000009201.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycerophosphoryl diester phosphodiesterase
CC family. {ECO:0000256|ARBA:ARBA00007277}.
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DR EMBL; AAKN02051173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005000777.1; XM_005000720.2.
DR STRING; 10141.ENSCPOP00000029098; -.
DR Ensembl; ENSCPOT00000010340.3; ENSCPOP00000009201.2; ENSCPOG00000010246.4.
DR Ensembl; ENSCPOT00000033856.1; ENSCPOP00000029098.1; ENSCPOG00000010246.4.
DR GeneID; 100728386; -.
DR KEGG; cpoc:100728386; -.
DR CTD; 81544; -.
DR VEuPathDB; HostDB:ENSCPOG00000010246; -.
DR eggNOG; KOG2258; Eukaryota.
DR GeneTree; ENSGT00940000159690; -.
DR HOGENOM; CLU_024259_1_0_1; -.
DR OMA; CKHCRYR; -.
DR OrthoDB; 203377at2759; -.
DR TreeFam; TF313692; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000010246; Expressed in frontal cortex and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR InterPro; IPR030395; GP_PDE_dom.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR PANTHER; PTHR23344:SF6; GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR23344; GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE; 1.
DR Pfam; PF03009; GDPD; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS51704; GP_PDE; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 228..485
FT /note="GP-PDE"
FT /evidence="ECO:0000259|PROSITE:PS51704"
FT REGION 580..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 605 AA; 68745 MW; 22EC5A0375EFCB32 CRC64;
MVRHQPLQYY EPQLCLSCLT GIYGCRWKRY QRSHDDTTPW ERLWFLLLTF TFGLTLTWLY
FWWDVHNDYD EFNWYLYNRV GYWSDWSVPI LVTTATAFTY IAGLLVLALC HIVVGQQMNL
HWLHKIGLVV ILGSTVVAMS AVAQLWEDEW EVLLISLQGT SPFLHLGGLA AVTMLSWIVA
GQFARAERSS SQVTMLGIFF TVVFALYLVP LTISSPCIME KKNLGPKPVL IGHRGAPMLA
PEHTLMSFRK ALEQKLYGIQ ADVTISLDGV PFLMHDATLR RTTNVEQAFP ELARRPASML
NWTVLQRLNA GQWFLKTDPF WTASSLSPSD HREAQNQSIC SLDELLELAK GNATLLLNLR
EPPRDHPFRS SFINVTLETL LRSGFPQHQV MWLPNRQRPF VRKVAPGFQQ TAGSKEALAS
LRRGHIQRLN LRYTQVSSQE LRDYASWNLS VNLYTVNAPW LFSLLWCTGV PSVTSDNSHI
LSQVPSPLWI MPPDEYCLMW VTADLISFTL IVGIFVFQKW RLGGIRSYNP EQIMLSAAVR
RTSRDVSIMK EKLIFSEISN GVEVSDEFSM CSDSSYDTYA NSTATPGGPQ GGSSQAKTFT
DRVGH
//
