ID H0VH20_CAVPO Unreviewed; 765 AA.
AC H0VH20;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Rac/Cdc42 guanine nucleotide exchange factor 6 {ECO:0000313|Ensembl:ENSCPOP00000009439.3};
GN Name=ARHGEF6 {ECO:0000313|Ensembl:ENSCPOP00000009439.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000009439.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000009439.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000009439.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02048066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02048067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02048068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VH20; -.
DR STRING; 10141.ENSCPOP00000009439; -.
DR Ensembl; ENSCPOT00000010606.3; ENSCPOP00000009439.3; ENSCPOG00000010511.4.
DR VEuPathDB; HostDB:ENSCPOG00000010511; -.
DR eggNOG; KOG2070; Eukaryota.
DR GeneTree; ENSGT00940000158723; -.
DR HOGENOM; CLU_017010_1_1_1; -.
DR InParanoid; H0VH20; -.
DR OMA; ITGNMVE; -.
DR TreeFam; TF316105; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000010511; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0030032; P:lamellipodium assembly; IEA:Ensembl.
DR CDD; cd21265; CH_alphaPIX; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd12060; SH3_alphaPIX; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035788; AlphaPIX_SH3.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 19..129
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 177..236
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 258..427
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 133..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 707..748
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 134..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 765 AA; 85986 MW; 5EA98FF6716BD31F CRC64;
MQSRMWLSPS VQSAPSAVMN PEERIVTWLI SLGVLDSPKK TICDPEEFLK SSLKNGVVLC
KLINRLMPGL VDKYCLEPQT EANCLSNINE FLKGCAALQV EVFDPDDLYS GVNFSKVLTT
LLAVNKATED QLSERPCGRS SSLSAANSSQ TSPQGAVSST APGPQKQAKA EMTENGSHQL
IVKARFNFKQ TNEDELSVCK GDIIYVTRIE EGGWWEGTLN GRTGWFPSNY VREIKSSERP
LSPKAVKGFE TAPLTKNYYT VVLQNILDTE KEYAKELQSL LLTYLKPLQS NNNLSTVEFT
SLLGNFEEIC TFQQTLCQAL EECSKFPENQ HKVGGCLLNL MPHFKSMYLA YCANHPSAVN
FMENQGASSP GILILTTSLS KPFMRLEKYV TLLQELERHM EDTHPDHQDI LKAIIAFKTL
MGQCQDLRKR KQLELQILSE PIQAWEGDDI KTLGNVIFMS QVMVQHGTCE EKEERYLMLF
SNVLIILSAS PRMSGFIYQG KIPIAGMVVT RLDEIEGNDC TFEITGRQFS PFHVAASNPF
WNEVESGSGG RLPASHQTFS QSFSSSGQPR GPLEPPQIIK PWSLSCLRPA PPLRPSAALG
YKERMSYILK ESSKSPKTMK KFLHKRKTER KPSEEEYVIR KSTAALEEDA QILKVIEAYC
TSANFQQGAR KDSVPQVLLP EEEKLIIEET RSNGQTIIEE KSLVDTVYAL KDEVKELKQE
NKRMKQCLEE ELKSRRDLEK LVRRLLKQTN ECILAESSSK ASILP
//
