ID H0VHA8_CAVPO Unreviewed; 947 AA.
AC H0VHA8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Protocadherin alpha subfamily C, 1 {ECO:0000313|Ensembl:ENSCPOP00000009534.3};
GN Name=PCDHAC1 {ECO:0000313|Ensembl:ENSCPOP00000009534.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000009534.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000009534.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000009534.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AAKN02009908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02009909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02009910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02009911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02009912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02009913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02009914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02009915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02009916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02009917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VHA8; -.
DR Ensembl; ENSCPOT00000010715.3; ENSCPOP00000009534.3; ENSCPOG00000009738.4.
DR VEuPathDB; HostDB:ENSCPOG00000009738; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000165142; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR TreeFam; TF332299; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000009738; Expressed in cerebellum and 12 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF92; PROTOCADHERIN ALPHA-1; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..947
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013311382"
FT TRANSMEM 695..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..133
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 134..242
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 243..350
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 351..455
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 456..565
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 578..675
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 771..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 827..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 898..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..947
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 947 AA; 102262 MW; EA06A6776BA7E368 CRC64;
MLFARKGGLT AWRLLPSLLL LAALEAGSGQ LHYSVPEEAK HGTFVGRIAQ DLGLELTELV
PRLFRVASKE RGELLEVNLQ NGILFVNSRI DREELCGRSA ECSIHLEVIM DRPLQVFHVE
VEVRDINDNP PVFRGRQQRV FISENRQLSS RFPIEGAADA DIGSNALLTY TLSSNDYFSL
DVQASDELSK SLSLKLRKAL DREATPEFRL LLRATDGGKP ELEDTVHLLI SVLDVNDNAP
VFDQALYKVH LLETTANGTL VITLNASDAD EGVNGEVVFS FGSDISPNIQ EKFKIEPSSG
EIRLIDNLDY EDTKSYEIQI KAVDKGSPPM SNHCKVLVKV LDVNDNAPQV VITSLSLPVR
EDAPLSTVVA LISVSDLDSG VNGEVTCSLS SHIPFKLVSS FKNYYSLVLD SALDRETFSD
YEVVVTARDG GSPPLWASAT VSVEVADVND NAPLFAQPEY TVFVKENNPP GAHIFTVCAR
DADAQENALV SYSLVERRVG ERALSSYVSV HAESGKVFAL QPLDHEELEL LQFQVSARDS
GVPALGSNMT LQVFVLDEND NAPALLGLSA GGTVSELVSR SVGASHVVTK VRAVDADSGY
NAWLSYELQA SVGGTRTPFR VSLYTGEIST TRTFDESDAS RQRLLVLVKD HGEPALTATA
TILLSLVESG QAPKASSRAL AGDSGLEVTL VDVNVYLIIA ICAVSSLLVL TLLLYTALRC
SAVPTEGSFG PGKPRLVCSS AEGSWSYSCQ RGQRVCSGEG PPKTDLIAFS PGLSPGLDTS
ERNEHTEANS DLSCNPRQPN PDWRYSASLR AGMHSSVHLE EAGILRAGPG GPDQQWPTVS
SATPEPEAGE VSPPVGAGVN SNSWTFKYGP GNPKQSGPGE LPDKFIIPGS PAIISIRQEP
ANSQIDKSDF ITFGKKEETK KKKKKKKGNK TQEKKEKGNS TTDNSDQ
//
