ID H0VHW7_CAVPO Unreviewed; 2139 AA.
AC H0VHW7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=Calcineurin binding protein 1 {ECO:0000313|Ensembl:ENSCPOP00000009766.3};
GN Name=CABIN1 {ECO:0000313|Ensembl:ENSCPOP00000009766.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000009766.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000009766.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000009766.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AAKN02007185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02007186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02007187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02007188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000009766; -.
DR Ensembl; ENSCPOT00000010972.3; ENSCPOP00000009766.3; ENSCPOG00000010872.4.
DR VEuPathDB; HostDB:ENSCPOG00000010872; -.
DR eggNOG; ENOG502QPUI; Eukaryota.
DR GeneTree; ENSGT00390000008529; -.
DR HOGENOM; CLU_000786_0_0_1; -.
DR InParanoid; H0VHW7; -.
DR OMA; DTDVTLW; -.
DR TreeFam; TF323227; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000010872; Expressed in cerebellum and 12 other cell types or tissues.
DR GO; GO:0016235; C:aggresome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0006334; P:nucleosome assembly; IEA:Ensembl.
DR CDD; cd13839; MEF2_binding; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR033053; Hir3/CABIN1.
DR InterPro; IPR015134; MEF2-bd.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR15502; CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED; 1.
DR PANTHER; PTHR15502:SF7; CALCINEURIN-BINDING PROTEIN CABIN-1; 1.
DR Pfam; PF09047; MEF2_binding; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 2.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 90..123
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 124..157
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 2075..2109
FT /note="Calcineurin-binding protein cabin-1 MEF2-binding"
FT /evidence="ECO:0000259|Pfam:PF09047"
FT REGION 1246..1408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1613..1798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1891..1917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1930..2083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2116..2139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1246..1268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1276..1295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1304..1318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1319..1350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1375..1391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1682..1703
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1767..1781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1930..1952
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1977..1992
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2006..2031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2125..2139
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2139 AA; 237442 MW; 18E1F643F90108E1 CRC64;
MIRIAALNAS STVEDDHEGN FKSHKTQTKE AQEAEAFALY HKALDLQKHD RFEESAKAYH
ELLEARLLRE AVSSGDEKEG LKHPGLILKY STYKNLAQLA AQREDLETAM EFYLEAVMLD
STDVNLWYKI GHVALRLIRL PLARHAFEEG LQCNPDHWPC LDNLITVLYT LSDYTTCLYF
ICKALEKDCR YSKGLVLKEK IFEEQPCLRK DSLRMFLKCD LSIHDVSVSA AESKAIVDEA
LGLRKKRQAL LVREKEPDLK LVQPIPFFTW KCLGESLLAM YNHLTTCETP RPSLGKRIDL
SEYQDPNHLP ASSMVVTPVS VIQPSPVSAN PTIAVAEPVL PYAPVAAASF PLHSPGLLDT
GAAMGDVSGG DKSKKGVKRK KISEECGETA KRRSARVRNT KCKKEEKVDF QELLVKFLPS
RLRKLDPEEE DDPFNNYEVQ SEAKLENFSS VGPHRLSFDS ATFMESEKQD VHKFLLENLT
NGGILELMMR YLKGMGNKFL LRWPPGLAEV VLSVYHSWRR HSTSLPNPLL RDCSNKHIKD
MMLMSLSCME LQLDQWLLTK GRSSAVSPRS CPTGVVNGRF GPDFPGTHCL GDLLQLSFAS
SQRDLFEDGW LEFVVRVYWL KARFLALQGD MEQALENYDI CTEMLQSSAT IQAEAGTEQR
DIIIRLPNLH NDSVVSLEEI DKNLKSLERC QSLEEIQRLY EAGDYKAVVH LLRPTLCTSG
FDQAKHLEFM TSIPERPAQL LLLQDSLLRL KDHQQCFECS EISLNEAVQQ MVNSSEAAAK
EEWVATVTQL LLGIEQTLSA DNSGSILKES SSTTGLVRLT NNLIQMSEAP MLPSSLMLLN
TAHEYLGRRS WCCNSDGALL RFYVRVLQKE LTASTSEDTH PYKEELETAL EQCFYCLYSF
PSKKSKARYL EEHSAQQVEL IWEDALFMFE YFKPKTLPEF DSYKTSTVSA DLANLLKRIA
TIVPRTERPG LSLEKVSAYI EGTSTEAPCL PEGADPSPPV VNELYYLLAD YHFKNKEQSK
AIKFYMHDIC ICPNRFDSWA GMALARASRI QDKLNSNELK SDGPIWKHAT PVLNCFRRAL
EIDSSNLSLW IEYGTMSYAL HSFASRQLKQ WRAELPPELV QQMESRRDSM LETARHCFTS
AAHCEGDGDE EEWLIHYMLG KVAEKQQQPP AVYLLHYRQA GHYLHEEAAR YPKKIHYHNP
PELAMEALEV FFRLHASILK LLGKPDSGVS AEVLVNFMKE AAEGPFARGE EKNTPKASEK
EKACLVDEDS HSSAGTLPGP GASFPSSSGP GLTSPPYTAT PIDHDYVKCK KPHQQATPDD
RSQDSTAVAL SDSSSTQDFF NEPTSSLESS RKPYAEKRVP VLSAQAGPSS KDLQGATEER
GKTEESLEST EGFRATEQSI QKPTADPPAA VSIPVKHLVS APVFCDGKKR GDPQGEPVVF
PQGLPADAEE QRQFLTEQCI ASFHLCLSRF PQHYKSLYRL AFLYTYSKTH RNLQWARDVL
LGSSIPWQQL QHMPAQGLFC ERNKTNFFNG IWRIPVDEID RPGSFAWHMN RSIVLLLKVL
AQLRDHSTLL KVSSMLQRTP DQGKKYLRDA DRQVLAQRAF ILTVKVLEDT LSELSEGSER
PGPKACGIPR ARMTTDVSHK ASPEDGQESL PNPKKTPLAD GSGPGPEPGT KVGSLNHRPM
VMDARDSADQ GGEQKDKESP RAGPTEPMDT GEAAICRPDL ERTPSLLPGR PLRDQGPESR
PAELSLEELS ISARQQPTPP TSAPVVPTAN AGPTTASGAR GSSHPEEPPL QPSRKRKLLE
DTESGKTLLL DAYRVWQQGQ KGVAYDLGRI ERIMSETYML IKQVDEEAAL EQAVKFCQVH
LGAAAQRQAS GDTPTTPKHL KDSRETFFPA AVVPTTPDPV PADALQRPSD THAKPRSALA
AVTAIISCSP SASVSTLDPS KDSGTPPTRP EATPSMASLG PEGERLGGVA EGTSFPPQEP
PRSQQEKTAS AGPSSEPHCW PVESAPQTGT EPTCSQATSS KVSSTGSTQP PEGHPGKVEP
SRAKSRLLPN MPKLVIPSAT TKFPPEITVT PPTPTLLSPK GSISEETKQK LKSAILSAQS
AANVRKESLC QPALEVLETS SQESSLESET DEDDDYMDI
//