ID H0VI30_CAVPO Unreviewed; 827 AA.
AC H0VI30;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Spectrin repeat containing nuclear envelope family member 3 {ECO:0000313|Ensembl:ENSCPOP00000009835.3};
GN Name=SYNE3 {ECO:0000313|Ensembl:ENSCPOP00000009835.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000009835.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000009835.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000009835.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nesprin family.
CC {ECO:0000256|ARBA:ARBA00008619}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02052262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02052263; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02052264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013000291.1; XM_013144837.1.
DR AlphaFoldDB; H0VI30; -.
DR STRING; 10141.ENSCPOP00000009835; -.
DR Ensembl; ENSCPOT00000011045.3; ENSCPOP00000009835.3; ENSCPOG00000010944.4.
DR GeneID; 100725886; -.
DR KEGG; cpoc:100725886; -.
DR VEuPathDB; HostDB:ENSCPOG00000010944; -.
DR eggNOG; ENOG502QQSI; Eukaryota.
DR GeneTree; ENSGT00440000039367; -.
DR HOGENOM; CLU_012764_0_0_1; -.
DR InParanoid; H0VI30; -.
DR OMA; ACCLEDQ; -.
DR OrthoDB; 4106312at2759; -.
DR TreeFam; TF331132; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000010944; Expressed in ovary and 13 other cell types or tissues.
DR GO; GO:0034993; C:meiotic nuclear membrane microtubule tethering complex; IEA:Ensembl.
DR GO; GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0140444; F:cytoskeleton-nuclear membrane anchor activity; IEA:Ensembl.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0090150; P:establishment of protein localization to membrane; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR Gene3D; 1.20.58.60; -; 2.
DR InterPro; IPR012315; KASH.
DR PANTHER; PTHR47535; MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G; 1.
DR PANTHER; PTHR47535:SF2; NESPRIN-3; 1.
DR Pfam; PF10541; KASH; 1.
DR SMART; SM01249; KASH; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 3.
DR PROSITE; PS51049; KASH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00385};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TOPO_DOM 1..777
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT TRANSMEM 778..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 799..827
FT /note="Perinuclear space"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT DOMAIN 769..827
FT /note="KASH"
FT /evidence="ECO:0000259|PROSITE:PS51049"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 140..202
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 827 AA; 92747 MW; B19C15A4714091B4 CRC64;
MRQCKKMTAP GAISRAGPEL SVTCSPDVPT HTQPRHAVAS EGRDPLRGVI SPPQDRVDLL
TRVAQEHEEY QAAVDEFQLW LRAAVEKAQA CTGSGCQLPT ELRLSTLQDL AKDFSQGEEA
LRRLEAWSAG IIQHTSPLGA EKIARELEEM RRVLEKQRIL WGEEEAQLQD LLSSKDARER
QLRRLEAELG EFQKGLQRLA QGGLEPSVKG KTAGTEDELV ARWRLYSASR AALASEEPRV
ARLQAQLKEL VAFPDLQPLC DSVVVAIQEY KSMKGKSTRL CNSTRVELWQ RFQRPLRDLQ
LWRALAQRLL DVTVSLPDLP SVHTFLPQIE AALAESARLK EQLAALPLKS DLLSGIFGQE
RASGLLAQVA GCMQDREPLH SSLLQRKGKL QGLLAQHKDF GAAFAPLQRK LLDLQARLQA
EKGLQRDLPA KQTQLLRLQG LQEEGLELEV HVEAMKCLVQ EDSSHQHKLD QLCSDYGALR
RSLEDLVDRS QQSVREHCTF SHQLMDLQQW VAVATQTLES HRGDLGLWNA ESREAGVEKL
VAEFPEKEAS LALVEAHGRL VMEKSSPEGA AEVQEELREL AESWRALRLL EEEMLSLIRN
RQLQSSEVDS GKKLVFTNNI PKSGFLIKPL DPVPGRRCSG PSAQADLLEE GEGGFEDGSQ
LLRNFEQWLR VENSKLVRII AMRVTSAKDV RTREAKLQEL QAQVPEGQRL FEDVLHLGPS
GAASEELEDL RYRWMLYKSK LKDAGHLLLQ SSAEESSAFQ TARRWRGPCS LLRKACCLAL
WLQLLLLLFL LLLFLLPAGE EARGCIRANN FASSFMLMLR YDGPPPT
//
